Showing entry for Glutamate receptor ionotropic, NMDA 2C


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013514
Protein NameGlutamate receptor ionotropic, NMDA 2C
Uniport IdQ14957
GeneGRIN2C
Gene Id2905
DomainANF_receptor; Lig_chan; Lig_chan-Glu_bd; NMDAR2_C
Pfam PF01094   PF00060   PF10613   PF10565  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
6. Human Diseases 6.4 Neurodegenerative diseases hsa05014 Amyotrophic lateral sclerosis (ALS)
6. Human Diseases 6.5 Substance dependence hsa05030 Cocaine addiction
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007420 brain development
Biological Process GO:0097553 calcium ion transmembrane import into cytosol
Biological Process GO:0033058 directional locomotion
Biological Process GO:0098976 excitatory chemical synaptic transmission
Biological Process GO:0060079 excitatory postsynaptic potential
Biological Process GO:0007215 glutamate receptor signaling pathway
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:1903539 protein localization to postsynaptic membrane
Biological Process GO:0048167 regulation of synaptic plasticity
Biological Process GO:0009611 response to wounding
molecular function GO:0022849 glutamate-gated calcium ion channel activity
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0004972 NMDA glutamate receptor activity
molecular function GO:0038023 signaling receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0017146 NMDA selective glutamate receptor complex
cellular component GO:0005886 plasma membrane
cellular component GO:0098839 postsynaptic density membrane
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-438064 Post NMDA receptor activation events
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-8849932 Synaptic adhesion-like molecules
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission
R-HSA-9620244 Long-term potentiation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1266129 BXGD011970 Atypical Lipoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0003196 Aripiprazole 448.39
BXGC0006162 L-Glutamic acid 147.13
BXGC0025485 Transtorine 189.04
BXGC0028885 Secobarbital 238.13
BXGC0043578 5-Hydroxy-2-(2-Phenylethyl)Chromen-4-One 266.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein