Showing entry for 5-Hydroxy-2-(2-Phenylethyl)Chromen-4-One


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0043578
Compound Name5-Hydroxy-2-(2-Phenylethyl)Chromen-4-One
Structure
FormulaC17H14O3
InchiKeyOLLHYYCQHNBTQC-UHFFFAOYSA-N
SMILESOc1cccc2c1c(=O)cc(o2)CCc1ccccc1
InchiInChI=1S/C17H14O3/c18-14-7-4-8-16-17(14)15(19)11-13(20-16)10-9-12-5-2-1-3-6-12/h1-8,11,18H,9-10H2
IUPAC5-hydroxy-2-(2-phenylethyl)chromen-4-one
Molecular Weight266.09
Pubchem Id11536299
Chembl IdCHEMBL479683
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50449333
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A 2512 - - -
CHEMBL CHEMBL479683
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Inhibition '=' 4 %
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Activity '=' 0 %
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 2454 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 8912 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Inhibition '=' 2 %
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Inhibition '=' 34 %
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Inhibition '=' 22 %
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D Inhibition '=' 4 %
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Inhibition '=' 5 %
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Inhibition '=' 6 %
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 79432 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Inhibition '=' 62 %
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Inhibition '=' 28 %
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 Inhibition '=' 0 %
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 89125 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 '=' 8912 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Inhibition '=' 32 %
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Inhibition '=' 14 %
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Inhibition '=' 1 %
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 35481 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Inhibition '=' 19 %
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Inhibition '=' 1 %
P28566 BXGT009274 5-hydroxytryptamine receptor 1E reviewed G-protein coupled receptor HTR1E Inhibition '=' 55 %
P28566 BXGT009274 5-hydroxytryptamine receptor 1E reviewed G-protein coupled receptor HTR1E Ki '>' 10000 nM
P46098 BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A Ki '=' 2511 nM
Q8TCU5 BXGT018802 Glutamate receptor ionotropic, NMDA 3A reviewed Ion channel GRIN3A Inhibition '=' 17 %
Q14957 BXGT013514 Glutamate receptor ionotropic, NMDA 2C reviewed Ion channel GRIN2C Inhibition '=' 17 %
O60391 BXGT004874 Glutamate receptor ionotropic, NMDA 3B reviewed Ion channel GRIN3B Inhibition '=' 17 %
O15399 BXGT004164 Glutamate receptor ionotropic, NMDA 2D reviewed Ion channel GRIN2D Inhibition '=' 17 %
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B reviewed Ion channel GRIN2B Inhibition '=' 17 %
Q12879 BXGT013275 Glutamate receptor ionotropic, NMDA 2A reviewed Ion channel GRIN2A Inhibition '=' 17 %
Q05586 BXGT012826 Glutamate receptor ionotropic, NMDA 1 reviewed Ion channel GRIN1 Inhibition '=' 17 %
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Inhibition '=' 35 %
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Inhibition '=' 5 %
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B Inhibition '=' 2 %
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A Inhibition '=' 16 %
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 Inhibition '=' 15 %
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Inhibition '=' 13 %
P46098 BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A Inhibition '=' 61 %
P28222 BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B Inhibition '=' 3 %
P30536 BXGT009435 Translocator protein reviewed - TSPO Inhibition '=' 2 %
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Inhibition '=' 24 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF03682 Imperata cylindrica Imperata cylindrica Medicinal Plant
BXGF04341 Sanguisorba officinalis Sanguisorba officinalis Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease