Showing entry for Aripiprazole


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0003196
Compound NameAripiprazole
Structure
FormulaC23H27Cl2N3O2
InchiKeyCEUORZQYGODEFX-UHFFFAOYSA-N
SMILESClC1=CC=CC(N2CCN(CCCCOC3=CC4=C(CCC(=O)N4)C=C3)CC2)=C1Cl
InchiInChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
IUPAC7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one
Molecular Weight448.39
Pubchem Id60795
Chembl IdCHEMBL1112
Targets of Information Source
DrugBank DB01238
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A approved; investigational partial agonist
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 approved; investigational antagonist,partial agonist
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A approved; investigational antagonist,partial agonist
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A approved; investigational antagonist
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B approved; investigational antagonist
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 approved; investigational antagonist,partial agonist
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D approved; investigational antagonist,ligand
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 approved; investigational antagonist,partial agonist
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A approved; investigational antagonist
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C approved; investigational antagonist,other/unknown
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 approved; investigational antagonist
P28222 BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B approved; investigational antagonist,ligand
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C approved; investigational antagonist,partial agonist
P46098 BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A approved; investigational antagonist
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 approved; investigational antagonist
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 approved; investigational antagonist,partial agonist,ligand
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 approved; investigational antagonist,partial agonist
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B approved; investigational antagonist,ligand
P28566 BXGT009274 5-hydroxytryptamine receptor 1E reviewed G-protein coupled receptor HTR1E approved; investigational antagonist,ligand
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 approved; investigational antagonist,partial agonist,ligand
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B approved; investigational inverse agonist
P47898 BXGT010594 5-hydroxytryptamine receptor 5A reviewed G-protein coupled receptor HTR5A approved; investigational ligand
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 approved; investigational ligand
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 approved; investigational ligand
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 approved; investigational ligand
Q9Y5N1 BXGT022297 Histamine H3 receptor reviewed G-protein coupled receptor HRH3 approved; investigational ligand
Q9H3N8 BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 approved; investigational ligand
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 approved; investigational ligand
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 approved; investigational ligand
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 approved; investigational ligand
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 approved; investigational ligand
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 approved; investigational ligand
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 approved; investigational ligand
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 approved; investigational ligand
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 approved; investigational ligand
Q05586 BXGT012826 Glutamate receptor ionotropic, NMDA 1 reviewed Ion channel GRIN1 approved; investigational -
Q12879 BXGT013275 Glutamate receptor ionotropic, NMDA 2A reviewed Ion channel GRIN2A approved; investigational -
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B reviewed Ion channel GRIN2B approved; investigational -
Q14957 BXGT013514 Glutamate receptor ionotropic, NMDA 2C reviewed Ion channel GRIN2C approved; investigational -
O15399 BXGT004164 Glutamate receptor ionotropic, NMDA 2D reviewed Ion channel GRIN2D approved; investigational -
Q8TCU5 BXGT018802 Glutamate receptor ionotropic, NMDA 3A reviewed Ion channel GRIN3A approved; investigational -
O60391 BXGT004874 Glutamate receptor ionotropic, NMDA 3B reviewed Ion channel GRIN3B approved; investigational ligand
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 approved; investigational modulator
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 approved; investigational modulator
PDB 9SC
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P02768 BXGT005955 Serum albumin reviewed ALB Transporter - - - 7.51
Binding DB 50130293
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 0.8 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 1.2 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 0.4 - - -
reviewed BXGT009532 5-hydroxytryptamine receptor 6 reviewed Htr6 161 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 14.5 - - -
reviewed BXGT008440 D(1A) dopamine receptor reviewed Drd1 410 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 0.52 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 1.71 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 4.7 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 0.59 - - -
reviewed BXGT008448 D(3) dopamine receptor reviewed Drd3 9.1 - - -
reviewed BXGT008448 D(3) dopamine receptor reviewed Drd3 6.06 - - -
reviewed BXGT009461 D(4) dopamine receptor reviewed Drd4 260 - - -
reviewed BXGT009024 D(1B) dopamine receptor reviewed Drd5 1200 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 8.7 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 22.4 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 783.2 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 9.6 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 26 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 74 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 102 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 37 - - -
reviewed BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 4677 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 0.66 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 29.7 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 5.6 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B 830 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D 68 - - -
reviewed BXGT009274 5-hydroxytryptamine receptor 1E reviewed G-protein coupled receptor HTR1E 8000 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 35 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 22 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 0.36 - - -
reviewed BXGT006838 5-hydroxytryptamine receptor 2C reviewed Htr2c 76 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 97 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 180 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 22 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 75 - - -
reviewed BXGT009849 5-hydroxytryptamine receptor 3A reviewed Htr3a 630 - - -
reviewed BXGT010594 5-hydroxytryptamine receptor 5A reviewed G-protein coupled receptor HTR5A 1240 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 570 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 10.3 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 25.7 - - -
reviewed BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B 34.8 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 74.3 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 103 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 37.9 - - -
reviewed BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 141 - - -
reviewed BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 163 - - -
reviewed BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 6780 - - -
reviewed BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 3510 - - -
reviewed BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 4680 - - -
reviewed BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 1520 - - -
reviewed BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 2330 - - -
reviewed BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 1960 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 3.3 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 0.74 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 9.7 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 1 - - -
reviewed BXGT009461 D(4) dopamine receptor reviewed Drd4 510 - - -
reviewed BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 2590 - - -
reviewed BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 3220 - - -
reviewed BXGT011460 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Gabra1 >10000 - - -
reviewed BXGT022401 Gamma-aminobutyric acid type B receptor subunit 1 reviewed Gabbr1 >10000 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 25.1 - - -
reviewed BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 >10000 - - -
reviewed BXGT020813 Histamine H3 receptor reviewed HRH3 224 - - -
reviewed BXGT020463 Histamine H4 receptor reviewed G-protein coupled receptor HRH4 >10000 - - -
reviewed BXGT009831 Glutamate receptor ionotropic, NMDA 1 reviewed Grin1 4001 - - -
reviewed BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 2090 - - -
reviewed BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 >10000 - - -
reviewed BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 >10000 - - -
reviewed BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 >10000 - - -
reviewed BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA >10000 - - -
reviewed BXGT006322 Protein kinase C gamma type reviewed Kinase PRKCG 8000 - - -
reviewed BXGT010356 Prostaglandin E2 receptor EP3 subtype reviewed G-protein coupled receptor PTGER3 >10000 - - -
reviewed BXGT009828 Prostaglandin E2 receptor EP4 subtype reviewed G-protein coupled receptor PTGER4 >10000 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 4.4 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 3.1 - - -
reviewed BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 1000 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 9 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 1.6 - - -
reviewed BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 240 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 130 - - -
reviewed BXGT006594 Histone H1.0 reviewed Nucleic acid binding H1F0 28 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a - 3.35 - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a - 11.51 - -
reviewed BXGT008448 D(3) dopamine receptor reviewed Drd3 - 37.9 - -
reviewed BXGT006838 5-hydroxytryptamine receptor 2C reviewed Htr2c - 25.7 - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 8 - - -
reviewed BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 895 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 19 - - -
reviewed BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 251 - - -
reviewed BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 1051 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 40 - - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 1.4 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 250 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 18 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A - - - 450
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 3 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 4 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 0.54 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 0.45 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 - - - 20
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 - 11 - -
reviewed BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 310 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 - - - 160
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 3.3 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 0.8 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 0.343 - - -
reviewed BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 57 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 - - - 158
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 - - - 39
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 0.48 - - -
reviewed BXGT008440 D(1A) dopamine receptor reviewed Drd1 1960 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 8.7 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 5.6 - - -
reviewed BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 1020 - - -
reviewed BXGT010214 1,3-beta-glucan synthase component GSC2 reviewed GSC2 - 3860 - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C - 1380 - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 - 420 - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A - 170 - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A - 2790 - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A - - - 285
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 - 17 - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 25 - - -
reviewed BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 1080 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 10 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 3.3 - - -
reviewed BXGT008440 D(1A) dopamine receptor reviewed Drd1 0.8 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 7 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 4 - - -
reviewed BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 598 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 1.8 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 9.6 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 10.3 - - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 780 - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 574 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 3.1 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 6.8 - - -
reviewed BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 168 - - -
reviewed BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 98 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 0.8 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 14 - - -
reviewed BXGT009534 Histamine H1 receptor reviewed Hrh1 - >3000 - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 0.4 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 7 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 2.6 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 2.8 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 - - - 1
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 - - - 4
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 3.9 - - -
reviewed BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 - 630.96 - -
reviewed BXGT017618 Multidrug and toxin extrusion protein 2 reviewed Transporter SLC47A2 - >500000 - -
reviewed BXGT019660 Multidrug and toxin extrusion protein 1 reviewed Transporter SLC47A1 - 130000 - -
reviewed BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 - 239000 - -
reviewed BXGT009565 Sodium-dependent serotonin transporter reviewed Slc6a4 1080 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 26 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 90 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 21 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 - 7.6 - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 0.2 - - -
CHEMBL CHEMBL1112
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Ki '=' 8 nM
Q96FL8 BXGT019660 Multidrug and toxin extrusion protein 1 reviewed Transporter SLC47A1 IC50 '=' 130000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 461 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 14125 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 14125 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '=' 10 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 1000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 log(activity) '=' 0 -
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '=' 18 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Alpha max '=' 0 -
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 50118 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 9 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Activity - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 1 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 0 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki '>' 1000 nM
P31652 BXGT009565 Sodium-dependent serotonin transporter reviewed - Slc6a4 Ki '=' 1080 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ratio '=' 8 -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 90 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 67 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '>' 5000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 '=' 11 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 4 nM
P18901 BXGT008440 D(1A) dopamine receptor reviewed - Drd1 Ki '=' 1960 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 '=' 2790 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '=' 5 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 630 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Intrinsic activity '=' 37 %
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A IC50 '=' 170 nM
O15244 BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 IC50 '=' 239000 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 22793 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 11220 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '<' 1000 nM
P31390 BXGT009534 Histamine H1 receptor reviewed - Hrh1 IC50 '>' 3000 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 891 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 4 nM
P97718 BXGT012217 Alpha-1A adrenergic receptor reviewed - Adra1a ED50 '>' 286 umol.kg-1
P97717 BXGT012216 Alpha-1B adrenergic receptor reviewed - Adra1b ED50 '>' 286 umol.kg-1
P97714 BXGT012215 Alpha-1D adrenergic receptor reviewed - Adra1d ED50 '>' 286 umol.kg-1
P08909 BXGT006838 5-hydroxytryptamine receptor 2C reviewed - Htr2c Ki '=' 76 nM
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Activity - - -
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Ki '=' 63 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki '=' 100 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Ki '=' 100 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki '=' 100 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '=' 57 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 21 nM
P61169 BXGT011367 D(2) dopamine receptor reviewed - Drd2 Ki '=' 3 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 28183 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 3 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 15848 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 2 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 158 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '=' 7 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki '=' 598 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 1 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Selectivity ratio '=' 0 -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Selectivity ratio '=' 0 -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 39810 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 0 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 50 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 1 nM
P18901 BXGT008440 D(1A) dopamine receptor reviewed - Drd1 Ki '=' 0 nM
Q60492 BXGT015986 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 5 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 15 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Activity - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki '=' 98 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 22 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a Activity - - -
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b Activity - - -
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c Activity - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 6 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 10 nM
P28566 BXGT009274 5-hydroxytryptamine receptor 1E reviewed G-protein coupled receptor HTR1E Ki '>' 1000 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 1000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 0 nM
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki '=' 1080 nM
P46098 BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A Ki '=' 1000 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '=' 1000 nM
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B Ki '=' 100 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki '=' 895 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 4 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki '=' 1020 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '=' 10 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '<=' 2 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 160 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 0 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Emax '=' 52 %
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 133000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Inhibition - - -
P47898 BXGT010594 5-hydroxytryptamine receptor 5A reviewed G-protein coupled receptor HTR5A Ki '=' 1000 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 1 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 62 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 8 nM
P11308 BXGT007684 Transcriptional regulator ERG reviewed Transcription factor ERG Potency - 7943 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 39 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Inhibition '=' 96 %
P07305 BXGT006594 Histone H1.0 reviewed Nucleic acid binding H1-0 Ki '=' 28 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 pKA '=' 8 -
P31389 BXGT009533 Histamine H1 receptor reviewed - HRH1 Ki '=' 100 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 0 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '=' 81 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 8 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 29092 nM
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki '>' 1000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 0 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Activity '=' 49 %
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Activity '=' 0 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ratio '=' 10 -
P19020 BXGT008448 D(3) dopamine receptor reviewed - Drd3 IC50 '=' 37 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 199 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 1 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 250 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '=' 63 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 1100 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 2 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 T1/2 '=' 0 hr
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki '=' 0 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '=' 7 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Intrinsic activity '=' 43 %
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki '=' 31 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 1778 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 3 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ratio Ki '=' 0 -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 574 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 33498 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 11 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 '=' 11 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ratio '=' 446 -
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Ki '=' 26 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki '=' 5 nM
P61169 BXGT011367 D(2) dopamine receptor reviewed - Drd2 Ki '=' 0 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Ki '=' 7 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 2 nM
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Ki '=' 14 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '=' 100 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 9 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '>' 1000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 38 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Activity '=' 69 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 43 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 pKA '=' 6 -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 9 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 EC50 - 92469 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 133000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 29 %
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki '=' 25 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Ki '=' 25 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki '=' 25 nM
Q6W5P4 BXGT016588 Neuropeptide S receptor reviewed - NPSR1 Potency '=' 12589 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Selectivity ratio '=' 1 -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Selectivity ratio '=' 1 -
Q61327 BXGT016017 Sodium-dependent dopamine transporter reviewed - Slc6a3 ED50 '=' 0 umol.kg-1
Q8WXA8 BXGT019008 5-hydroxytryptamine receptor 3C reviewed Ion channel HTR3C Ki '=' 501 nM
Q70Z44 BXGT016686 5-hydroxytryptamine receptor 3D reviewed Ion channel HTR3D Ki '=' 501 nM
O95264 BXGT005367 5-hydroxytryptamine receptor 3B reviewed Ion channel HTR3B Ki '=' 501 nM
A5X5Y0 BXGT001376 5-hydroxytryptamine receptor 3E reviewed Ion channel HTR3E Ki '=' 501 nM
P46098 BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A Ki '=' 501 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 0 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 14 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 '=' 420 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 56234 nM
P08909 BXGT006838 5-hydroxytryptamine receptor 2C reviewed - Htr2c IC50 '=' 25 nM
Q86VL8 BXGT017618 Multidrug and toxin extrusion protein 2 reviewed Transporter SLC47A2 IC50 '>' 500000 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 7943 nM
P0A0J7 BXGT006970 Quinolone resistance protein NorA reviewed - norA Inhibition '=' 92 %
P30729 BXGT009461 D(4) dopamine receptor reviewed - Drd4 Ki '=' 510 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 3860 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 '=' 1380 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A EC50 '=' 285 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki '=' 310 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 100 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 130 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 13335 nM
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 Ki '>' 1000 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 707 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '=' 168 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 39810 nM
P35363 BXGT009818 5-hydroxytryptamine receptor 2A reviewed - Htr2a EC50 - 8393 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 10 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 51 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 0 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 0 nM
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Ki '=' 100 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 2 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Inhibition '=' 99 %
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki '>' 1000 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki '>' 1000 nM
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Ki '=' 44 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Intrinsic activity '=' 29 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 '=' 7 nM
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 Ki '=' 1051 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ratio '=' 6 -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Intrinsic activity '=' 30 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Intrinsic activity '=' 0 -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 deltalog(Tau/KA) '=' 0 -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 deltalog(Tau/KA) '=' -2 -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 deltalog(Tau/KA) '=' 0 -
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '=' 30 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '=' 251 nM
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Inhibition '=' 43 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 deltalog(Tau/KA) '=' 0 -
P31652 BXGT009565 Sodium-dependent serotonin transporter reviewed - Slc6a4 IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 1 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Activity - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 3 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 EC50 '=' 20 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 14581 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 3 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki '=' 1000 nM
P28222 BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B Ki '=' 1000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Imax '=' 0 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 0 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 3 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 14 %
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 3 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 deltalog(Tau/KA) '=' 0 -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 log(activity) '=' 0 -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '=' 57 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 '=' 3 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 17 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 780 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 3 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 13 %
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 EC50 '=' 19 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Activity - - -
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a IC50 '=' 11 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 4 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 130 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 100 nM
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A Ki '=' 100 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 8 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A EC50 '=' 450 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 4 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Activity '=' 91 %
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 100 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki '>' 1000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 8 %
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A Ki '=' 26 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Inhibition '=' 0 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 3 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 3 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 7079 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '<' 15 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '<' 10 %
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 19 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 740 nM
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 Ki '=' 1600 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 EC50 '=' 19 nM
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D Ki '=' 100 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '<' 1 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 81 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 82 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 1 nM
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki '=' 240 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 70 %
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Activity '=' 0 %
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Ki '=' 10 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 0 nM
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 '=' 1100 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ratio '=' 20 -
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A EC50 '=' 24 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 71 %
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 40 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Inhibition '=' 40 %
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 63 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 '=' 17 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki '=' 25 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 '>' 100000 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 89 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 '=' 32 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Emax '=' 12 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00050 Chinese cinnamon Cinnamomum aromaticum Herbs and Spices
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease