Showing entry for [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013541
Protein Name[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Uniport IdQ15119
GenePDK2
Gene Id5164
DomainBCDHK_Adom3; HATPase_c
Pfam PF10436   PF02518  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031670 cellular response to nutrient
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:1904183 negative regulation of pyruvate dehydrogenase activity
Biological Process GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
Biological Process GO:0050848 regulation of calcium-mediated signaling
Biological Process GO:0010565 regulation of cellular ketone metabolic process
Biological Process GO:0006111 regulation of gluconeogenesis
Biological Process GO:0010906 regulation of glucose metabolic process
Biological Process GO:0006885 regulation of pH
molecular function GO:0005524 ATP binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
cellular component GO:0005829 cytosol
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005967 mitochondrial pyruvate dehydrogenase complex
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-70268 Pyruvate metabolism
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-9006931 Signaling by Nuclear Receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0596887 BXGD009648 mathematical ability
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000696 Tartaric acid 150.09
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0028613 abietyl alcohol 288.25
BXGC0037224 Dichloroacetic Acid 127.94
BXGC0041564 Abietic Acid 302.22
BXGC0048229 [(1R,4As,10Ar)-1,4A-Dimethyl-7-Propan-2-Yl-2,3,4,9,10,10A-Hexahydrophenanthren-1-Yl]Methanamine 285.25
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein