Showing entry for Hsp90 co-chaperone Cdc37


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013635
Protein NameHsp90 co-chaperone Cdc37
Uniport IdQ16543
GeneCDC37
Gene Id11140
DomainCDC37_C; CDC37_M; CDC37_N
Pfam PF08564   PF08565   PF03234  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0038128 ERBB2 signaling pathway
Biological Process GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
Biological Process GO:0010608 posttranscriptional regulation of gene expression
Biological Process GO:0006457 protein folding
Biological Process GO:0050821 protein stabilization
Biological Process GO:0006605 protein targeting
Biological Process GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process GO:0060334 regulation of interferon-gamma-mediated signaling pathway
Biological Process GO:0060338 regulation of type I interferon-mediated signaling pathway
molecular function GO:0051087 chaperone binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0051879 Hsp90 protein binding
molecular function GO:0019900 kinase binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0019887 protein kinase regulator activity
molecular function GO:0097110 scaffold protein binding
molecular function GO:0051082 unfolded protein binding
cellular component GO:0101031 chaperone complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:1990565 HSP90-CDC37 chaperone complex
Reactome
Pathway Id Pathway Name
R-HSA-1227986 Signaling by ERBB2
R-HSA-1227990 Signaling by ERBB2 in Cancer
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1643713 Signaling by EGFR in Cancer
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218859 Regulated Necrosis
R-HSA-5357801 Programmed Cell Death
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5637812 Signaling by EGFRvIII in Cancer
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5675482 Regulation of necroptotic cell death
R-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling
R-HSA-9664565 Signaling by ERBB2 KD Mutants
R-HSA-9665230 Drug resistance in ERBB2 KD mutants
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib
R-HSA-9665348 Signaling by ERBB2 ECD mutants
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0031269 BXGD002297 Peutz-Jeghers Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Skin and Connective Tissue Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0238013 BXGD004855 Invasive aspergillosis Infections
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1608408 BXGD013434 Malignant transformation
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C2004493 BXGD016875 Leukemia, B-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2937421 BXGD018162 Prostatic Hyperplasia Male Urogenital Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0014048 Celastrol 450.28
BXGC0020368 Gambogic Acid 628.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein