adisease

Showing entry for Retinoblastoma

General Disease Information
BXGD Id	BXGD002540
Disease Name	Retinoblastoma
Disease CUI Id	C0035335
MeSH Codes	C04 C11
Disease Class Name	Neoplasms; Eye Diseases
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0002664 HP:0000478
Human Phenotype Ontology Term	Neoplasm; Abnormality of the eye
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00255	BXGT003903	Menin	4221	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O00472	BXGT003927	RNA polymerase II elongation factor ELL2	22936	reviewed	Cell-cell junction
O00571	BXGT003938	ATP-dependent RNA helicase DDX3X	1654	reviewed
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O14744	BXGT004089	Protein arginine N-methyltransferase 5	10419	reviewed	Epigenetic regulator
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14757	BXGT004092	Serine/threonine-protein kinase Chk1	1111	reviewed	Kinase
O14936	BXGT004114	Peripheral plasma membrane protein CASK	8573	reviewed	Kinase
O14980	BXGT004119	Exportin-1	7514	reviewed	Receptor
O15151	BXGT004132	Protein Mdm4	4194	reviewed	Nucleic acid binding
O15297	BXGT004149	Protein phosphatase 1D	8493	reviewed	Enzyme
O15350	BXGT004154	Tumor protein p73	7161	reviewed	Transcription factor
O15439	BXGT004169	Multidrug resistance-associated protein 4	10257	reviewed	Transporter
O15550	BXGT004179	Lysine-specific demethylase 6A	7403	reviewed	Epigenetic regulator
O15553	BXGT004181	Pyrin	4210	reviewed
O43324	BXGT004588	Eukaryotic translation elongation factor 1 epsilon-1	9521	reviewed
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75044	BXGT005097	SLIT-ROBO Rho GTPase-activating protein 2	23380	reviewed	Enzyme modulator
O75164	BXGT005104	Lysine-specific demethylase 4A	9682	reviewed
O75475	BXGT005130	PC4 and SFRS1-interacting protein	11168	reviewed	Signaling
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	8989	reviewed	Ion channel
O75828	BXGT005154	Carbonyl reductase [NADPH] 3	874	reviewed
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
O75884	BXGT005159	Putative hydrolase RBBP9	10741	reviewed
O96017	BXGT005415	Serine/threonine-protein kinase Chk2	11200	reviewed	Kinase
P00338	BXGT005504	L-lactate dehydrogenase A chain	3939	reviewed	Enzyme
P00374	BXGT005520	Dihydrofolate reductase	1719	reviewed	Enzyme
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00740	BXGT005634	Coagulation factor IX	2158	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P00966	BXGT005707	Argininosuccinate synthase	445	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02511	BXGT005885	Alpha-crystallin B chain	1410	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02655	BXGT005912	Apolipoprotein C-II	344	reviewed
P02750	BXGT005942	Leucine-rich alpha-2-glycoprotein	116844	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04155	BXGT006155	Trefoil factor 1	7031	reviewed	Signaling
P04181	BXGT006165	Ornithine aminotransferase, mitochondrial	4942	reviewed	Enzyme
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05090	BXGT006311	Apolipoprotein D	347	reviewed
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P05787	BXGT006385	Keratin, type II cytoskeletal 8	3856	reviewed
P06493	BXGT006445	Cyclin-dependent kinase 1	983	reviewed	Kinase
P06730	BXGT006487	Eukaryotic translation initiation factor 4E	1977	reviewed	Nucleic acid binding
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P06733	BXGT006490	Alpha-enolase	2023	reviewed	Enzyme
P06744	BXGT006494	Glucose-6-phosphate isomerase	2821	reviewed	Enzyme
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P06753	BXGT006498	Tropomyosin alpha-3 chain	7170	reviewed	Cellular structure
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07305	BXGT006594	Histone H1.0	3005	reviewed	Nucleic acid binding
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P07996	BXGT006710	Thrombospondin-1	7057	reviewed
P08047	BXGT006720	Transcription factor Sp1	6667	reviewed	Nucleic acid binding
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08100	BXGT006725	Rhodopsin	6010	reviewed	G-protein coupled receptor
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08700	BXGT006816	Interleukin-3	3562	reviewed
P08912	BXGT006840	Muscarinic acetylcholine receptor M5	1133	reviewed	G-protein coupled receptor
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09455	BXGT006890	Retinol-binding protein 1	5947	reviewed
P0CG48	BXGT007468	Polyubiquitin-C	7316	reviewed	Nucleic acid binding
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10301	BXGT007556	Ras-related protein R-Ras	6237	reviewed	Enzyme modulator
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10745	BXGT007608	Retinol-binding protein 3	5949	reviewed
P10768	BXGT007611	S-formylglutathione hydrolase	2098	reviewed	Enzyme
P10909	BXGT007630	Clusterin	1191	reviewed
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11717	BXGT007740	Cation-independent mannose-6-phosphate receptor	3482	reviewed	Receptor
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P11926	BXGT007760	Ornithine decarboxylase	4953	reviewed	Enzyme
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12724	BXGT007837	Eosinophil cationic protein	6037	reviewed
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P13796	BXGT007956	Plastin-2	3936	reviewed	Cellular structure
P13945	BXGT007972	Beta-3 adrenergic receptor	155	reviewed	G-protein coupled receptor
P14635	BXGT008031	G2/mitotic-specific cyclin-B1	891	reviewed	Enzyme modulator
P14679	BXGT008039	Tyrosinase	7299	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15328	BXGT008108	Folate receptor alpha	2348	reviewed
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16070	BXGT008186	CD44 antigen	960	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P17844	BXGT008346	Probable ATP-dependent RNA helicase DDX5	1655	reviewed
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18089	BXGT008379	Alpha-2B adrenergic receptor	151	reviewed	G-protein coupled receptor
P18847	BXGT008431	Cyclic AMP-dependent transcription factor ATF-3	467	reviewed	Transcription factor
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P21359	BXGT008640	Neurofibromin	4763	reviewed	Enzyme modulator
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P22033	BXGT008721	Methylmalonyl-CoA mutase, mitochondrial	4594	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P23443	BXGT008866	Ribosomal protein S6 kinase beta-1	6198	reviewed	Kinase
P23528	BXGT008879	Cofilin-1	1072	reviewed
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	6530	reviewed	Transporter
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24864	BXGT009000	G1/S-specific cyclin-E1	898	reviewed	Enzyme modulator
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P25440	BXGT009044	Bromodomain-containing protein 2	6046	reviewed	Epigenetic regulator
P25791	BXGT009072	Rhombotin-2	4005	reviewed
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	5295	reviewed	Kinase
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28562	BXGT009270	Dual specificity protein phosphatase 1	1843	reviewed
P28908	BXGT009302	Tumor necrosis factor receptor superfamily member 8	943	reviewed
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29372	BXGT009336	DNA-3-methyladenine glycosylase	4350	reviewed	Enzyme
P29375	BXGT009338	Lysine-specific demethylase 5A	5927	reviewed
P30279	BXGT009415	G1/S-specific cyclin-D2	894	reviewed	Enzyme modulator
P30281	BXGT009416	G1/S-specific cyclin-D3	896	reviewed	Enzyme modulator
P30291	BXGT009417	Wee1-like protein kinase	7465	reviewed	Kinase
P30304	BXGT009418	M-phase inducer phosphatase 1	993	reviewed	Enzyme
P30305	BXGT009419	M-phase inducer phosphatase 2	994	reviewed	Enzyme
P30307	BXGT009421	M-phase inducer phosphatase 3	995	reviewed	Enzyme
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32004	BXGT009594	Neural cell adhesion molecule L1	3897	reviewed
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P34998	BXGT009781	Corticotropin-releasing factor receptor 1	1394	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35243	BXGT009803	Recoverin	5957	reviewed
P35348	BXGT009814	Alpha-1A adrenergic receptor	148	reviewed	G-protein coupled receptor
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35610	BXGT009855	Sterol O-acyltransferase 1	6646	reviewed	Enzyme
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P36956	BXGT009947	Sterol regulatory element-binding protein 1	6720	reviewed
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P39060	BXGT010088	Collagen alpha-1(XVIII) chain	80781	reviewed
P40337	BXGT010174	von Hippel-Lindau disease tumor suppressor	7428	reviewed	Enzyme
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P41208	BXGT010233	Centrin-2	1069	reviewed	Calcium-binding protein
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P41440	BXGT010261	Folate transporter 1	6573	reviewed	Transporter
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P43405	BXGT010386	Tyrosine-protein kinase SYK	6850	reviewed	Kinase
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P46597	BXGT010528	Acetylserotonin O-methyltransferase	438	reviewed
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P49711	BXGT010728	Transcriptional repressor CTCF	10664	reviewed	Transcription factor
P49763	BXGT010737	Placenta growth factor	5228	reviewed	Signaling
P49902	BXGT010758	Cytosolic purine 5'-nucleotidase	22978	reviewed	Enzyme
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P50120	BXGT010773	Retinol-binding protein 2	5948	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P50750	BXGT010818	Cyclin-dependent kinase 9	1025	reviewed	Kinase
P51532	BXGT010852	Transcription activator BRG1	6597	reviewed	Epigenetic regulator
P51858	BXGT010900	Hepatoma-derived growth factor	3068	reviewed	Signaling
P51878	BXGT010902	Caspase-5	838	reviewed	Enzyme
P51955	BXGT010908	Serine/threonine-protein kinase Nek2	4751	reviewed	Kinase
P52292	BXGT010925	Importin subunit alpha-1	3838	reviewed	Transporter
P53350	BXGT010984	Serine/threonine-protein kinase PLK1	5347	reviewed	Kinase
P54762	BXGT011076	Ephrin type-B receptor 1	2047	reviewed	Kinase
P55157	BXGT011108	Microsomal triglyceride transfer protein large subunit	4547	reviewed	Transporter
P56524	BXGT011176	Histone deacetylase 4	9759	reviewed	Epigenetic regulator
P56945	BXGT011206	Breast cancer anti-estrogen resistance protein 1	9564	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61024	BXGT011350	Cyclin-dependent kinases regulatory subunit 1	1163	reviewed	Enzyme modulator
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P62136	BXGT011407	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	5499	reviewed	Enzyme
P62979	BXGT011476	Ubiquitin-40S ribosomal protein S27a	6233	reviewed	Nucleic acid binding
P63146	BXGT011504	Ubiquitin-conjugating enzyme E2 B	7320	reviewed
P63279	BXGT011514	SUMO-conjugating enzyme UBC9	7329	reviewed
P78310	BXGT011830	Coxsackievirus and adenovirus receptor	1525	reviewed
P78396	BXGT011842	Cyclin-A1	8900	reviewed	Enzyme modulator
P78504	BXGT011844	Protein jagged-1	182	reviewed
P82279	BXGT011972	Protein crumbs homolog 1	23418	reviewed
P83916	BXGT012025	Chromobox protein homolog 1	10951	reviewed	Epigenetic regulator
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q00534	BXGT012533	Cyclin-dependent kinase 6	1021	reviewed	Kinase
Q00535	BXGT012534	Cyclin-dependent-like kinase 5	1020	reviewed	Kinase
Q00613	BXGT012540	Heat shock factor protein 1	3297	reviewed	Transcription factor
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01094	BXGT012568	Transcription factor E2F1	1869	reviewed	Nucleic acid binding
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	8140	reviewed	Transporter
Q02363	BXGT012650	DNA-binding protein inhibitor ID-2	3398	reviewed	Transcription factor
Q02643	BXGT012660	Growth hormone-releasing hormone receptor	2692	reviewed	G-protein coupled receptor
Q03154	BXGT012698	Aminoacylase-1	95	reviewed
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	5467	reviewed	Nuclear receptor
Q03403	BXGT012712	Trefoil factor 2	7032	reviewed	Signaling
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q06418	BXGT012875	Tyrosine-protein kinase receptor TYRO3	7301	reviewed	Kinase
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q08050	BXGT012958	Forkhead box protein M1	2305	reviewed
Q09028	BXGT013025	Histone-binding protein RBBP4	5928	reviewed
Q11130	BXGT013216	Alpha-(1,3)-fucosyltransferase 7	2529	reviewed	Enzyme
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q13009	BXGT013305	T-lymphoma invasion and metastasis-inducing protein 1	7074	reviewed
Q13126	BXGT013313	S-methyl-5'-thioadenosine phosphorylase	4507	reviewed	Enzyme
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13257	BXGT013333	Mitotic spindle assembly checkpoint protein MAD2A	4085	reviewed
Q13309	BXGT013338	S-phase kinase-associated protein 2	6502	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13324	BXGT013340	Corticotropin-releasing factor receptor 2	1395	reviewed	G-protein coupled receptor
Q13370	BXGT013345	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	5140	reviewed
Q13418	BXGT013351	Integrin-linked protein kinase	3611	reviewed	Kinase
Q13426	BXGT013353	DNA repair protein XRCC4	7518	reviewed
Q13464	BXGT013357	Rho-associated protein kinase 1	6093	reviewed	Kinase
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q13547	BXGT013373	Histone deacetylase 1	3065	reviewed	Epigenetic regulator
Q14002	BXGT013433	Carcinoembryonic antigen-related cell adhesion molecule 7	1087	reviewed
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q14393	BXGT013466	Growth arrest-specific protein 6	2621	reviewed	Extracellular structure
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q14494	BXGT013474	Endoplasmic reticulum membrane sensor NFE2L1	4779	reviewed	Enzyme
Q14680	BXGT013499	Maternal embryonic leucine zipper kinase	9833	reviewed	Kinase
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q14978	BXGT013517	Nucleolar and coiled-body phosphoprotein 1	9221	reviewed
Q15078	BXGT013534	Cyclin-dependent kinase 5 activator 1	8851	reviewed	Enzyme modulator
Q15118	BXGT013540	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	5163	reviewed	Kinase
Q15125	BXGT013543	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	10682	reviewed	Enzyme
Q15185	BXGT013549	Prostaglandin E synthase 3	10728	reviewed	Chaperone
Q15257	BXGT013554	Serine/threonine-protein phosphatase 2A activator	5524	reviewed	Enzyme modulator
Q15582	BXGT013581	Transforming growth factor-beta-induced protein ig-h3	7045	reviewed	Signaling
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16543	BXGT013635	Hsp90 co-chaperone Cdc37	11140	reviewed	Enzyme modulator
Q16576	BXGT013641	Histone-binding protein RBBP7	5931	reviewed
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16790	BXGT013670	Carbonic anhydrase 9	768	reviewed
Q53EL6	BXGT015008	Programmed cell death protein 4	27250	reviewed	Nucleic acid binding
Q5T6L4	BXGT015848	Argininosuccinate synthase 1 isoform 1	445	unreviewed
Q6PL18	BXGT016479	ATPase family AAA domain-containing protein 2	29028	reviewed	Epigenetic regulator
Q6ZQY3	BXGT016636	Acidic amino acid decarboxylase GADL1	339896	reviewed
Q86TM3	BXGT017607	Probable ATP-dependent RNA helicase DDX53	168400	reviewed
Q8IYD8	BXGT018367	Fanconi anemia group M protein	57697	reviewed	Enzyme
Q8N3J5	BXGT018506	Protein phosphatase 1K, mitochondrial	152926	reviewed	Enzyme
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8TDX7	BXGT018817	Serine/threonine-protein kinase Nek7	140609	reviewed	Kinase
Q92499	BXGT019350	ATP-dependent RNA helicase DDX1	1653	reviewed
Q92547	BXGT019355	DNA topoisomerase 2-binding protein 1	11073	reviewed
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q92900	BXGT019392	Regulator of nonsense transcripts 1	5976	reviewed	Enzyme
Q92905	BXGT019393	COP9 signalosome complex subunit 5	10987	reviewed	Enzyme
Q92945	BXGT019397	Far upstream element-binding protein 2	8570	reviewed	Enzyme
Q96A70	BXGT019615	Antizyme inhibitor 2	113451	reviewed	Enzyme
Q96AT9	BXGT019619	Ribulose-phosphate 3-epimerase	6120	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96T88	BXGT019747	E3 ubiquitin-protein ligase UHRF1	29128	reviewed
Q99593	BXGT019939	T-box transcription factor TBX5	6910	reviewed	Transcription factor
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q99933	BXGT019976	BAG family molecular chaperone regulator 1	573	reviewed
Q99986	BXGT019980	Serine/threonine-protein kinase VRK1	7443	reviewed	Kinase
Q9BXH1	BXGT020167	Bcl-2-binding component 3	27113	reviewed
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9H4B4	BXGT020474	Serine/threonine-protein kinase PLK3	1263	reviewed	Kinase
Q9HC98	BXGT020528	Serine/threonine-protein kinase Nek6	10783	reviewed	Kinase
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NRF2	BXGT021185	SH2B adapter protein 1	25970	reviewed
Q9NRM7	BXGT021190	Serine/threonine-protein kinase LATS2	26524	reviewed	Kinase
Q9NZN9	BXGT021280	Aryl-hydrocarbon-interacting protein-like 1	23746	reviewed	Chaperone
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9P2R7	BXGT021304	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	8803	reviewed	Enzyme
Q9UBB5	BXGT021649	Methyl-CpG-binding domain protein 2	8932	reviewed	Epigenetic regulator
Q9UBC3	BXGT021650	DNA (cytosine-5)-methyltransferase 3B	1789	reviewed
Q9UER7	BXGT021672	Death domain-associated protein 6	1616	reviewed
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9UPY3	BXGT021802	Endoribonuclease Dicer	23405	reviewed	Enzyme
Q9UQ84	BXGT021807	Exonuclease 1	9156	reviewed	Enzyme
Q9Y286	BXGT022225	Sialic acid-binding Ig-like lectin 7	27036	reviewed	Receptor
Q9Y289	BXGT022226	Sodium-dependent multivitamin transporter	8884	reviewed	Transporter
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y2W7	BXGT022250	Calsenilin	30818	reviewed	Ion channel
Q9Y5W5	BXGT022303	Wnt inhibitory factor 1	11197	reviewed	Calcium-binding protein
Q9Y5X9	BXGT022307	Endothelial lipase	9388	reviewed	Enzyme
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q92911	BXGT022650	Sodium/iodide cotransporter	6528	reviewed	Transporter
F1T0I5	BXGT022675	Arylalkylamine N-acetyltransferase (Serotonin N-acetyltransferase)	15	unreviewed
Q13029	BXGT022688	PR domain zinc finger protein 2	7799	reviewed
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
P35240	BXGT022927	Merlin	4771	reviewed
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
Q14186	BXGT023367	Transcription factor Dp-1	7027	reviewed	Nucleic acid binding
Q16254	BXGT023368	Transcription factor E2F4	1874	reviewed	Nucleic acid binding
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P40198	BXGT023750	Carcinoembryonic antigen-related cell adhesion molecule 3	1084	reviewed
Q96QC4	BXGT023878	MHC class I polypeptide-related sequence A	100507436	unreviewed
Q13007	BXGT023883	Interleukin-24	11009	reviewed
Q9HAU4	BXGT024040	E3 ubiquitin-protein ligase SMURF2	64750	reviewed	Enzyme
O60232	BXGT024169	Protein ZNRD2	10534	reviewed
Q15678	BXGT024385	Tyrosine-protein phosphatase non-receptor type 14	5784	reviewed
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
A8MW92	BXGT024730	PHD finger protein 20-like protein 1	51105	reviewed
Q9GZV5	BXGT025439	WW domain-containing transcription regulator protein 1	25937	reviewed	Enzyme modulator
P35251	BXGT025853	Replication factor C subunit 1	5981	reviewed
Q9UKB1	BXGT025928	F-box/WD repeat-containing protein 11	23291	reviewed
Q14566	BXGT025969	DNA replication licensing factor MCM6	4175	reviewed	Enzyme
P33993	BXGT025970	DNA replication licensing factor MCM7	4176	reviewed	Enzyme
Q92888	BXGT026130	Rho guanine nucleotide exchange factor 1	9138	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
Q05209	BXGT026141	Tyrosine-protein phosphatase non-receptor type 12	5782	reviewed
V9HWB9	BXGT026149	L-lactate dehydrogenase	3939	unreviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}