Showing entry for HER2-positive carcinoma of breast


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD016658
Disease NameHER2-positive carcinoma of breast
Disease CUI IdC1960398
MeSH Codes C04   C17  
Disease Class NameNeoplasms; Skin and Connective Tissue Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14672 BXGT004081 Disintegrin and metalloproteinase domain-containing protein 10 102 reviewed
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O15379 BXGT004159 Histone deacetylase 3 8841 reviewed Epigenetic regulator
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 8714 reviewed Transporter
O15540 BXGT004178 Fatty acid-binding protein, brain 2173 reviewed
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O43570 BXGT004601 Carbonic anhydrase 12 771 reviewed
O75251 BXGT005107 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 374291 reviewed
O96020 BXGT005416 G1/S-specific cyclin-E2 9134 reviewed Enzyme modulator
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04083 BXGT006147 Annexin A1 301 reviewed
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04278 BXGT006182 Sex hormone-binding globulin 6462 reviewed
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06401 BXGT006436 Progesterone receptor 5241 reviewed Nuclear receptor
P06493 BXGT006445 Cyclin-dependent kinase 1 983 reviewed Kinase
P07332 BXGT006601 Tyrosine-protein kinase Fes/Fps 2242 reviewed Kinase
P07550 BXGT006636 Beta-2 adrenergic receptor 154 reviewed G-protein coupled receptor
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P07947 BXGT006701 Tyrosine-protein kinase Yes 7525 reviewed Kinase
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08174 BXGT006739 Complement decay-accelerating factor 1604 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08637 BXGT006802 Low affinity immunoglobulin gamma Fc region receptor III-A 2214 reviewed Cell adhesion
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09466 BXGT006892 Glycodelin 5047 reviewed Enzyme
P09486 BXGT006897 SPARC 6678 reviewed Signaling
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11388 BXGT007697 DNA topoisomerase 2-alpha 7153 reviewed
P11474 BXGT007710 Steroid hormone receptor ERR1 2101 reviewed Nuclear receptor
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12318 BXGT007799 Low affinity immunoglobulin gamma Fc region receptor II-a 2212 reviewed Cell adhesion
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P13674 BXGT007942 Prolyl 4-hydroxylase subunit alpha-1 5033 reviewed
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P14635 BXGT008031 G2/mitotic-specific cyclin-B1 891 reviewed Enzyme modulator
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15311 BXGT008106 Ezrin 7430 reviewed Cellular structure
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16671 BXGT008255 Platelet glycoprotein 4 948 reviewed Receptor
P17655 BXGT008325 Calpain-2 catalytic subunit 824 reviewed Enzyme
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 5770 reviewed
P18848 BXGT008432 Cyclic AMP-dependent transcription factor ATF-4 468 reviewed
P19174 BXGT008467 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 5335 reviewed Enzyme
P19525 BXGT008492 Interferon-induced, double-stranded RNA-activated protein kinase 5610 reviewed Kinase
P19801 BXGT008516 Amiloride-sensitive amine oxidase [copper-containing] 26 reviewed
P19883 BXGT008528 Follistatin 10468 reviewed Enzyme modulator
P20827 BXGT008606 Ephrin-A1 1942 reviewed Kinase
P21860 BXGT008698 Receptor tyrosine-protein kinase erbB-3 2065 reviewed Kinase
P23297 BXGT008848 Protein S100-A1 6271 reviewed Calcium-binding protein
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28562 BXGT009270 Dual specificity protein phosphatase 1 1843 reviewed
P28908 BXGT009302 Tumor necrosis factor receptor superfamily member 8 943 reviewed
P29317 BXGT009331 Ephrin type-A receptor 2 1969 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29375 BXGT009338 Lysine-specific demethylase 5A 5927 reviewed
P29466 BXGT009349 Caspase-1 834 reviewed Enzyme
P30530 BXGT009431 Tyrosine-protein kinase receptor UFO 558 reviewed Kinase
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31751 BXGT009576 RAC-beta serine/threonine-protein kinase 208 reviewed Kinase
P31785 BXGT009577 Cytokine receptor common subunit gamma 3561 reviewed Signaling
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35613 BXGT009856 Basigin 682 reviewed
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 2324 reviewed Kinase
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P39748 BXGT010134 Flap endonuclease 1 2237 reviewed Enzyme
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P40933 BXGT010209 Interleukin-15 3600 reviewed
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P47895 BXGT010593 Aldehyde dehydrogenase family 1 member A3 220 reviewed Enzyme
P48506 BXGT010635 Glutamate--cysteine ligase catalytic subunit 2729 reviewed Enzyme
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49327 BXGT010694 Fatty acid synthase 2194 reviewed Enzyme
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P51790 BXGT010890 H(+)/Cl(-) exchange transporter 3 1182 reviewed Ion channel
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P54756 BXGT011074 Ephrin type-A receptor 5 2044 reviewed Kinase
P54760 BXGT011075 Ephrin type-B receptor 4 2050 reviewed Kinase
P56945 BXGT011206 Breast cancer anti-estrogen resistance protein 1 9564 reviewed
P57058 BXGT011209 Hormonally up-regulated neu tumor-associated kinase 30811 reviewed Kinase
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P62753 BXGT011454 40S ribosomal protein S6 6194 reviewed Nucleic acid binding
P62993 BXGT011480 Growth factor receptor-bound protein 2 2885 reviewed
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
Q00613 BXGT012540 Heat shock factor protein 1 3297 reviewed Transcription factor
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q01813 BXGT012618 ATP-dependent 6-phosphofructokinase, platelet type 5214 reviewed Kinase
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 5604 reviewed Kinase
Q03518 BXGT012723 Antigen peptide transporter 1 6890 reviewed Transporter
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q04912 BXGT012790 Macrophage-stimulating protein receptor 4486 reviewed Kinase
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13177 BXGT013323 Serine/threonine-protein kinase PAK 2 5062 reviewed Kinase
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q13535 BXGT013370 Serine/threonine-protein kinase ATR 545 reviewed Kinase
Q13618 BXGT013382 Cullin-3 8452 reviewed
Q13882 BXGT013399 Protein-tyrosine kinase 6 5753 reviewed Kinase
Q14289 BXGT013459 Protein-tyrosine kinase 2-beta 2185 reviewed Kinase
Q14451 BXGT013471 Growth factor receptor-bound protein 7 2886 reviewed Receptor
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q15561 BXGT013578 Transcriptional enhancer factor TEF-3 7004 reviewed Transcription factor
Q15582 BXGT013581 Transforming growth factor-beta-induced protein ig-h3 7045 reviewed Signaling
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle 4638 reviewed Kinase
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q16543 BXGT013635 Hsp90 co-chaperone Cdc37 11140 reviewed Enzyme modulator
Q16739 BXGT013663 Ceramide glucosyltransferase 7357 reviewed Enzyme
Q16827 BXGT013675 Receptor-type tyrosine-protein phosphatase O 5800 reviewed
Q16875 BXGT013686 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 5209 reviewed Kinase
Q53EL6 BXGT015008 Programmed cell death protein 4 27250 reviewed Nucleic acid binding
Q8TAX9 BXGT018788 Gasdermin-B 55876 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q99519 BXGT019928 Sialidase-1 4758 reviewed Enzyme
Q99661 BXGT019946 Kinesin-like protein KIF2C 11004 reviewed Cellular structure
Q99728 BXGT019956 BRCA1-associated RING domain protein 1 580 reviewed
Q99814 BXGT019965 Endothelial PAS domain-containing protein 1 2034 reviewed Transcription factor
Q99933 BXGT019976 BAG family molecular chaperone regulator 1 573 reviewed
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9NPI8 BXGT021161 Fanconi anemia group F protein 2188 reviewed
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UNL4 BXGT021790 Inhibitor of growth protein 4 51147 reviewed Nucleic acid binding
Q9Y243 BXGT022214 RAC-gamma serine/threonine-protein kinase 10000 reviewed Kinase
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
P19235 BXGT022895 Erythropoietin receptor 2057 reviewed Receptor
Q9UK05 BXGT023094 Growth/differentiation factor 2 2658 reviewed Signaling
O75608 BXGT023330 Acyl-protein thioesterase 1 10434 reviewed
Q13007 BXGT023883 Interleukin-24 11009 reviewed
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
P16104 BXGT024571 Histone H2AX 3014 reviewed Nucleic acid binding
Q8NEZ4 BXGT024850 Histone-lysine N-methyltransferase 2C 58508 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease