Showing entry for NADP-dependent malic enzyme, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013672
Protein NameNADP-dependent malic enzyme, mitochondrial
Uniport IdQ16798
GeneME3
Gene Id10873
Domainmalic; Malic_M
Pfam PF00390   PF03949  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00620 Pyruvate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009060 aerobic respiration
Biological Process GO:0006108 malate metabolic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0072592 oxygen metabolic process
Biological Process GO:0006090 pyruvate metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle
molecular function GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
molecular function GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
molecular function GO:0004470 malic enzyme activity
molecular function GO:0046872 metal ion binding
molecular function GO:0051287 NAD binding
molecular function GO:0070401 NADP+ binding
molecular function GO:0008948 oxaloacetate decarboxylase activity
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism
R-HSA-71403 Citric acid cycle (TCA cycle)
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0014772 BXGD000948 Red Blood Cell Count measurement
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269955 BXGD012005 Tumor Cell Invasion
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1512127 BXGD013185 HER2 gene amplification
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001380 Succinic acid 118.09
BXGC0002436 Fumaric acid 116.07
BXGC0004188 Propanedioic acid 104.06
BXGC0029784 Fumaric Acid 116.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein