Showing entry for Propanedioic acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0004188
Compound NamePropanedioic acid
Structure
FormulaC3H4O4
InchiKeyOFOBLEOULBTSOW-UHFFFAOYSA-N
SMILESOC(=O)CC(O)=O
InchiInChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
IUPACpropanedioic acid
Molecular Weight104.06
Pubchem Id867
Chembl IdCHEMBL7942
Targets of Information Source
DrugBank DB02175
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
O07015 BXGT003999 Sigma factor SigB regulation protein RsbQ reviewed - rsbQ experimental -
P0A793 BXGT007101 Aspartate 1-decarboxylase reviewed - panD experimental -
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed Kinase SRC experimental -
Q9FCA6 BXGT020361 Biflaviolin synthase CYP158A2 reviewed - cyp158a2 experimental -
P09012 BXGT006849 U1 small nuclear ribonucleoprotein A reviewed Nucleic acid binding SNRPA experimental -
Q9ZIV5 BXGT022461 Malonamidase E2 unreviewed - - experimental -
Q8ZPC0 BXGT019229 Acetyl transferase unreviewed - rimL experimental -
PDB MLA
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P17412 BXGT008305 Fumarate reductase flavoprotein subunit reviewed frdA - - - - -
P09012 BXGT006849 U1 small nuclear ribonucleoprotein A reviewed SNRPA Nucleic acid binding - - - -
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed SRC Kinase - >40000000 - -
Q9ZIV5 BXGT022461 Malonamidase E2 unreviewed - - - - -
P0A790 BXGT007100 Aspartate 1-decarboxylase reviewed panD - - - - -
P52839 BXGT010959 Cytosolic sulfotransferase 12 reviewed SOT12 - - - - -
P42390 BXGT010308 Indole-3-glycerol phosphate lyase, chloroplastic reviewed BX1 - - - - -
Q9EV84 BXGT020321 Beta-subunit of trans-3-chloroacrylic acid dehalogenase unreviewed caaD2 - - - - -
Q9FCA6 BXGT020361 Biflaviolin synthase CYP158A2 reviewed cyp158a2 - - - - -
Q8ZPC0 BXGT019229 Acetyl transferase unreviewed rimL - - - - -
P13988 BXGT007976 Transposon Tn7 transposition protein TnsA reviewed tnsA - - - - -
P05846 BXGT006393 Transposon Tn7 transposition protein TnsC reviewed tnsC - - - - -
O07015 BXGT003999 Sigma factor SigB regulation protein RsbQ reviewed rsbQ - - - - -
Q57658 BXGT015129 Aspartate-semialdehyde dehydrogenase reviewed asd - - - - -
A2NAI0 BXGT001081 Variable region-beta 8.5 unreviewed - - - - -
Q54873 BXGT015048 Hyaluronate lyase reviewed SP_0314 - - - - -
P07203 BXGT006566 Glutathione peroxidase 1 reviewed GPX1 Enzyme - - - -
P21642 BXGT008673 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial reviewed PCK2 - 50000000 - - -
P0AEE5 BXGT007310 D-galactose-binding periplasmic protein reviewed mglB - - - - -
P0AAI9 BXGT007212 Malonyl CoA-acyl carrier protein transacylase reviewed fabD - - - - -
P13134 BXGT007884 Kexin reviewed KEX2 - - - - -
P35961 BXGT009885 Envelope glycoprotein gp160 reviewed env - - - - -
P01730 BXGT005781 T-cell surface glycoprotein CD4 reviewed CD4 - - - - -
A4F255 BXGT001211 Immunoblobulin G1 Fab heavy chain variable region unreviewed VHCH1 - - - - -
P09883 BXGT006936 Colicin-E9 reviewed col - - - - -
O95257 BXGT005365 Growth arrest and DNA damage-inducible protein GADD45 gamma reviewed GADD45G - - - - -
P13633 BXGT007931 C4-dicarboxylate transport sensor protein DctB reviewed dctB - - - - -
P75736 BXGT011752 Esterase YbfF reviewed ybfF - - - - -
Q99497 BXGT019926 Protein/nucleic acid deglycase DJ-1 reviewed PARK7 Enzyme - - - -
B6ETQ5 BXGT002201 C5a peptidase unreviewed scpA - - - - -
P40161 BXGT010162 Histone chaperone RTT106 reviewed RTT106 - - - - -
P03322 BXGT006050 Gag polyprotein reviewed gag - - - - -
P44969 BXGT010446 Immunoglobulin A1 protease autotransporter reviewed iga - - - - -
P9WNH1 BXGT012412 Putative non-heme bromoperoxidase BpoC reviewed bpoC - - - - -
Q8A6S1 BXGT017845 Electron transfer flavoprotein alpha-subunit unreviewed BT_1805 - - - - -
Q8PYS1 BXGT018669 Geranylfarnesyl diphosphate synthase reviewed MM_0789 - - - - -
A0A0H2VY20 BXGT000296 Altronate hydrolase unreviewed uxaA - - - - -
P04825 BXGT006271 Aminopeptidase N reviewed pepN - - - - -
Q45070 BXGT014610 Glucuronoxylanase XynC reviewed xynC - - - - -
Q2YQA0 BXGT014280 Isocitrate lyase and phosphorylmutase:Isocitrate lyase unreviewed BAB1_1631 - - - - -
Q9AIX7 BXGT020067 Benzoyl-CoA oxygenase component B reviewed boxB - - - - -
P49040 BXGT010674 Sucrose synthase 1 reviewed SUS1 - - - - -
P58687 BXGT011242 3-dehydroquinate dehydratase reviewed aroD - - - - -
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed GSK3B Kinase - - - -
P0CL19 BXGT007477 Putative ribose 5-phosphate isomerase reviewed CIMG_07932 - - - - -
Q8YUQ7 BXGT019141 Alr2278 protein unreviewed alr2278 - - - - -
A3LT82 BXGT001169 NADPH dehydrogenase unreviewed OYE2.6 - - - - -
P47229 BXGT010571 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase reviewed bphD - - - - -
Q2SWH9 BXGT014183 Threonine synthase unreviewed thrC - - - - -
D0VWQ0 BXGT002711 3-hydroxybutyrate dehydrogenase unreviewed DF183_01165 - - - - -
Q91786 BXGT019285 Galectin unreviewed lgals1.3.L - - - - -
D8LJ35 BXGT003020 Polyketide Synthase III unreviewed PKS - - - - -
Q9H269 BXGT020450 Vacuolar protein sorting-associated protein 16 homolog reviewed VPS16 - - - - -
P12821 BXGT007849 Angiotensin-converting enzyme reviewed ACE Enzyme - - - -
Q9XGM3 BXGT022181 Disease resistance protein RPS4 reviewed RPS4 - - - - -
A3DJS9 BXGT001148 Carbohydrate binding family 6 unreviewed Cthe_3012 - - - - -
D0X4R4 BXGT002773 D-galactonate dehydratase family member VME_00770 reviewed VME_00770 - - - - -
P02879 BXGT005982 Ricin reviewed - - - - -
Q8RX71 BXGT018750 BAG family molecular chaperone regulator 4 reviewed BAG4 - - - - -
P68106 BXGT011576 Peptidyl-prolyl cis-trans isomerase FKBP1B reviewed FKBP1B Enzyme - - - -
Q9NPH0 BXGT021157 Lysophosphatidic acid phosphatase type 6 reviewed ACP6 Enzyme - - - -
P46075 BXGT010504 Extracellular metalloproteinase mep reviewed mep - - - - -
Q0SPG7 BXGT013172 Autolytic lysozyme unreviewed CPR_C0050 - - - - -
P04585 BXGT006234 Gag-Pol polyprotein reviewed gag-pol - - - - -
Q8CHT0 BXGT017939 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial reviewed Aldh4a1 - - - - -
Q16875 BXGT013686 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 reviewed PFKFB3 Kinase - - - -
Q830Y8 BXGT017446 Nicotinate phosphoribosyltransferase unreviewed EF_2626 - - - - -
Q12HD7 BXGT013291 TRAP dicarboxylate transporter, DctP subunit unreviewed Bpro_0088 - - - - -
Q04636 BXGT012770 FACT complex subunit POB3 reviewed POB3 - - - - -
C5ATQ9 BXGT002510 Maleylacetoacetate isomerase (Glutathione S-transferase) unreviewed maiA - - - - -
Q88JL2 BXGT017718 Glucanase unreviewed bcsZ - - - - -
P13688 BXGT007943 Carcinoembryonic antigen-related cell adhesion molecule 1 reviewed CEACAM1 - - - - -
Q8D151 BXGT017960 Acyl-CoA thioesterase II unreviewed tesB - - - - -
Q2YNY7 BXGT014274 Ribokinase:Carbohydrate kinase, PfkB unreviewed cscK - - - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed CA2 - - - - -
Q14451 BXGT013471 Growth factor receptor-bound protein 7 reviewed GRB7 Receptor - - - -
P62992 BXGT011479 Ubiquitin-40S ribosomal protein S27a reviewed RPS27A - - - - -
Q7WXQ4 BXGT017200 Putative [NiFe] hydrogenase small subunit unreviewed PHG064 - - - - -
Q13237 BXGT013331 cGMP-dependent protein kinase 2 reviewed PRKG2 Kinase - - - -
Q8AAV8 BXGT017881 NUDIX family hydrolase unreviewed BT_0354 - - - - -
A0A0B4KIF6 BXGT000119 NicR unreviewed nicR - - - - -
A1JMF7 BXGT001007 Pectin degradation protein unreviewed kdgF - - - - -
A8PUY5 BXGT001718 Hypothetical secretory lipase (Family 3) unreviewed MGL_0799 - - - - -
Q9H7X0 BXGT020492 N-alpha-acetyltransferase 60 reviewed NAA60 Enzyme - - - -
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain reviewed HLA-DRB1 Immune response - - - -
A0A159BDB5 BXGT000682 Tail fiber unreviewed phiAB6_gp40 - - - - -
V9M2S5 BXGT022602 TIR-NB-LRR type resistance protein RPV1 reviewed RPV1 - - - - -
O53611 BXGT004707 Isocitrate dehydrogenase [NADP] unreviewed icd2 - - - - -
Q93009 BXGT019455 Ubiquitin carboxyl-terminal hydrolase 7 reviewed USP7 Enzyme - - - -
E9AE57 BXGT003165 Fumarate hydratase 2 reviewed FH2 - - - - -
D5DKI8 BXGT002945 Cytochrome P450 unreviewed BMD_3874 - - - - -
Q92LZ4 BXGT019422 Putative 2-hydroxyacid dehydrogenase unreviewed SMc04462 - - - - -
P00338 BXGT005504 L-lactate dehydrogenase A chain reviewed LDHA Enzyme - - - -
P23291 BXGT008846 Casein kinase I homolog 1 reviewed YCK1 - - - - -
Q3HV58 BXGT014419 Chemokine protease C unreviewed scpC - - - - -
Q5W271 BXGT015896 L-prolyl-[peptidyl-carrier protein] dehydrogenase reviewed pigA - - - - -
P31946 BXGT009588 14-3-3 protein beta/alpha reviewed YWHAB Chaperone - - - -
Q8IDJ8 BXGT018251 Lysine--tRNA ligase unreviewed PF3D7_1350100 - - - - -
P9WFX9 BXGT012256 Tryptophan synthase beta chain reviewed trpB - - - - -
Q7VTJ9 BXGT017164 Argininosuccinate synthase reviewed argG - - - - -
P9WFY1 BXGT012257 Tryptophan synthase alpha chain reviewed trpA - - - - -
G0S1Z8 BXGT024002 Mitochondrial frataxin-like protein unreviewed CTHT_0015430 - - - - -
A3DCJ4 BXGT001127 Dockerin type 1 unreviewed Cthe_0435 - - - - -
P01011 BXGT005715 Alpha-1-antichymotrypsin reviewed SERPINA3 Enzyme modulator - - - -
Q7NDN8 BXGT017055 Proton-gated ion channel reviewed glvI - - - - -
P48730 BXGT010656 Casein kinase I isoform delta reviewed CSNK1D Kinase - - - -
Q9Y3E1 BXGT024320 Hepatoma-derived growth factor-related protein 3 reviewed HDGFL3 Signaling - - - -
U5Q2N8 BXGT024369 XimE unreviewed ximE - - - - -
Q94CL7 BXGT024432 Protein PHOSPHATE STARVATION RESPONSE 1 reviewed PHR1 - - - - -
Q58531 BXGT024524 GMP synthase [glutamine-hydrolyzing] subunit B reviewed guaAB - - - - -
O60341 BXGT004873 Lysine-specific histone demethylase 1A reviewed KDM1A Epigenetic regulator - - - -
Q3JRA0 BXGT014460 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase reviewed ispF - - - - -
Q6RFZ0 BXGT024977 Beta-lactamase unreviewed blaOXA-54 - - - - -
Q4KCY5 BXGT025050 L-proline--[L-prolyl-carrier protein] ligase reviewed pltF - - - - -
Q1HRL7 BXGT013800 AAEL005772-PA unreviewed 5567053 - - - - -
Q9BV73 BXGT025119 Centrosome-associated protein CEP250 reviewed CEP250 Enzyme modulator - - - -
P54195 BXGT025360 General odorant-binding protein 28a reviewed Obp28a - - - - -
E9AE57 BXGT003165 Fumarate hydratase 2 reviewed FH2 - - 5600000 - -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed IDH1 - - - - -
B2UQG6 BXGT026067 Beta-N-acetylhexosaminidase unreviewed Amuc_0868 - - - - -
Binding DB 14673
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT021400 Serine racemase reviewed Srr 27000 - - -
reviewed BXGT021400 Serine racemase reviewed Srr - 67000 - -
reviewed BXGT020424 Serine racemase reviewed Enzyme SRR - 1310000 - -
reviewed BXGT020424 Serine racemase reviewed Enzyme SRR 33000 - - -
reviewed BXGT020424 Serine racemase reviewed Enzyme SRR 59000 - - -
reviewed BXGT020424 Serine racemase reviewed Enzyme SRR 66000 - - -
reviewed BXGT019341 D-aspartate oxidase reviewed Ddo 1220000 - - -
reviewed BXGT019924 D-aspartate oxidase reviewed DDO 153000 - - -
reviewed BXGT008067 D-amino-acid oxidase reviewed DAO - >10000000 - -
reviewed BXGT019924 D-aspartate oxidase reviewed DDO - 879000 - -
reviewed BXGT021400 Serine racemase reviewed Srr 71000 - - -
reviewed BXGT020424 Serine racemase reviewed Enzyme SRR - 24900 - -
reviewed BXGT019924 D-aspartate oxidase reviewed DDO - 1355000 - -
CHEMBL CHEMBL7942
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q99489 BXGT019924 D-aspartate oxidase reviewed - DDO Inhibition - - -
Q9QZX7 BXGT021400 Serine racemase reviewed - Srr Ki '=' 27000 nM
P14920 BXGT008067 D-amino-acid oxidase reviewed - DAO Activity - - -
Q9GZT4 BXGT020424 Serine racemase reviewed Enzyme SRR IC50 '=' 1310000 nM
Q16798 BXGT013672 NADP-dependent malic enzyme, mitochondrial reviewed Enzyme ME3 Activity - - -
Q9GZT4 BXGT020424 Serine racemase reviewed Enzyme SRR Inhibition - - -
Q9QZX7 BXGT021400 Serine racemase reviewed - Srr Ki '=' 71000 nM
Q9GZT4 BXGT020424 Serine racemase reviewed Enzyme SRR IC50 '=' 24900 nM
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed Kinase SRC IC50 '>' 40000000 nM
Q99489 BXGT019924 D-aspartate oxidase reviewed - DDO IC50 '=' 1355000 nM
P00338 BXGT005504 L-lactate dehydrogenase A chain reviewed Enzyme LDHA Kd '=' 5000000 nM
Q9GZT4 BXGT020424 Serine racemase reviewed Enzyme SRR Ki '=' 33000 nM
D3ZDM7 BXGT002917 D-aspartate oxidase unreviewed - Ddo Ki '=' 1562000 nM
P14920 BXGT008067 D-amino-acid oxidase reviewed - DAO IC50 '>' 10000000 nM
Q99489 BXGT019924 D-aspartate oxidase reviewed - DDO Ki '=' 153000 nM
Q9QZX7 BXGT021400 Serine racemase reviewed - Srr IC50 '=' 67000 nM
Q99489 BXGT019924 D-aspartate oxidase reviewed - DDO IC50 '=' 879000 nM
Q9GZT4 BXGT020424 Serine racemase reviewed Enzyme SRR Ki '=' 59000 nM
Q9GZT4 BXGT020424 Serine racemase reviewed Enzyme SRR Ki '=' 66000 nM
Q922Z0 BXGT019341 D-aspartate oxidase reviewed - Ddo Ki '=' 1220000 nM
Q9GZT4 BXGT020424 Serine racemase reviewed Enzyme SRR Inhibition '=' 59 %
Q9GZT4 BXGT020424 Serine racemase reviewed Enzyme SRR Inhibition '=' 76 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00015 Wild celery Apium graveolens Herbs and Spices
BXGF00022 Oat Avena sativa Cereals and cereal products
BXGF00025 Common beet Beta vulgaris Vegetables
BXGF00040 Pepper (C. annuum) Capsicum annuum Vegetables
BXGF00053 Lime Citrus aurantiifolia Fruits
BXGF00056 Mandarin orange (Clementine, Tangerine) Citrus reticulata Fruits
BXGF00057 Sweet orange Citrus sinensis Fruits
BXGF00064 Muskmelon Cucumis melo Gourds
BXGF00081 Fig Ficus carica Fruits
BXGF00086 Sunflower Helianthus annuus Herbs and Spices
BXGF00088 Barley Hordeum vulgare Cereals and cereal products
BXGF00132 Scarlet bean Phaseolus coccineus Pulses
BXGF00134 Common bean Phaseolus vulgaris Pulses
BXGF00149 Peach Prunus persica Fruits
BXGF00205 Corn Zea mays Cereals and cereal products
BXGF00246 Red beetroot Beta vulgaris var. rubra Vegetables
BXGF00393 Pepper (C. frutescens) Capsicum annuum var. annuum Vegetables
BXGF00400 French plantain Musa X paradisiaca Fruits
BXGF00829 Green bell pepper Capsicum annuum Vegetables
BXGF00830 Yellow bell pepper Capsicum annuum Vegetables
BXGF00831 Orange bell pepper Capsicum annuum Vegetables
BXGF00832 Red bell pepper Capsicum annuum Vegetables
BXGF01140 Angelica gigas Angelica gigas Medicinal Plant
BXGF01279 Coleostephus myconis Coleostephus myconis Medicinal Plant
BXGF01505 Gynostemma pentaphyllum Gynostemma pentaphyllum Medicinal Plant
BXGF02049 Angelica sinensis Angelica sinensis Medicinal Plant
BXGF02276 Synotis alata Synotis alata Others
BXGF04820 Panax ginseng Panax ginseng 0
BXGF04842 Angelica acutiloba Angelica acutiloba Medicinal Plant
BXGF04889 Pogostemon cablin Pogostemon cablin Medicinal Plant
BXGF06171 Dahlia pinnata Dahlia pinnata Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease