acompound

Showing entry for Fumaric Acid

General Compound Information
BXGC Id	BXGC0029784
Compound Name	Fumaric Acid
Structure
Formula	C4H4O4
InchiKey	VZCYOOQTPOCHFL-OWOJBTEDSA-N
SMILES	OC(=O)/C=C/C(=O)O
Inchi	InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
IUPAC	(E)-but-2-enedioic acid
Molecular Weight	116.01
Pubchem Id	444972
Chembl Id	CHEMBL503160

Targets of Information Source

DrugBank

DB01677

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P80040	BXGT011870	Malate dehydrogenase	reviewed	-	mdh	experimental; investigational	-
P0C278	BXGT007409	Fumarate reductase flavoprotein subunit	reviewed	-	fccA	experimental; investigational	-
P83223	BXGT011987	Fumarate reductase flavoprotein subunit	reviewed	-	SO_0970	experimental; investigational	-
P23368	BXGT008856	NAD-dependent malic enzyme, mitochondrial	reviewed	Enzyme	ME2	experimental; investigational	-
P16930	BXGT008272	Fumarylacetoacetase	reviewed	-	FAH	experimental; investigational	-

PDB

FUM

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
P83223	BXGT011987	Fumarate reductase flavoprotein subunit	reviewed	SO_0970	-	-	-	-	-
P0C278	BXGT007409	Fumarate reductase flavoprotein subunit	reviewed	fccA	-	-	-	-	-
P23368	BXGT008856	NAD-dependent malic enzyme, mitochondrial	reviewed	ME2	Enzyme	-	-	-	-
P35505	BXGT009841	Fumarylacetoacetase	reviewed	Fah	-	-	-	-	-
P17412	BXGT008305	Fumarate reductase flavoprotein subunit	reviewed	frdA	-	-	-	-	-
P80040	BXGT011870	Malate dehydrogenase	reviewed	mdh	-	-	-	-	-
Q9NWT6	BXGT021234	Hypoxia-inducible factor 1-alpha inhibitor	reviewed	HIF1AN	-	-	-	-	-
Q4D3W2	BXGT014786	Dihydroorotate dehydrogenase (fumarate)	reviewed	pyr4	-	-	-	-	-
Q5SKN7	BXGT015774	Aspartate 1-decarboxylase	reviewed	panD	-	-	-	-	-
P0AB89	BXGT007222	Adenylosuccinate lyase	reviewed	purB	-	-	-	-	-
P30566	BXGT009446	Adenylosuccinate lyase	reviewed	ADSL	Enzyme	-	-	-	-
P00363	BXGT005515	Fumarate reductase flavoprotein subunit	reviewed	frdA	-	-	-	-	-
B0TZW0	BXGT001861	L-amino acid-D/L-Glu epimerase	reviewed	Fphi_1647	-	-	-	-	-
Q13PB7	BXGT013421	Uncharacterized protein	unreviewed	Bxe_B1897	-	-	-	-	-
Q4QEW7	BXGT014876	Dihydroorotate dehydrogenase (fumarate)	unreviewed	DHODH	-	-	-	-	-
Q33862	BXGT014328	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	unreviewed		-	-	-	-	-
P9WN93	BXGT012406	Fumarate hydratase class II	reviewed	fumC	-	-	-	-	-
O68395	BXGT005027	TutD	unreviewed	tutD	-	-	-	-	-
O14607	BXGT004075	Histone demethylase UTY	reviewed	UTY	Transcription factor	-	-	-	-
Q9UGL1	BXGT021685	Lysine-specific demethylase 5B	reviewed	KDM5B	Epigenetic regulator	-	-	-	-
O75164	BXGT005104	Lysine-specific demethylase 4A	reviewed	KDM4A	-	-	-	-	-
Q5NIQ1	BXGT015615	Adenylosuccinate lyase	unreviewed	purB	-	-	-	-	-
E5XP76	BXGT003137	Thioester reductase domain-containing protein	unreviewed	HMPREF9336_01297	-	-	-	-	-
A0A384E0N4	BXGT023281	Adenylosuccinate lyase	unreviewed	ADSL	-	-	-	-	-
T2GB49	BXGT022552	Putative fumarate reductase flavoprotein subunit	unreviewed	fdrA	-	-	-	-	-
A0A0K2JL82	BXGT000531	CreD	unreviewed	creD	-	-	-	-	-
Q11KV9	BXGT013220	Argininosuccinate lyase	unreviewed	Meso_0564	-	-	-	-	-
Q7NDN8	BXGT017055	Proton-gated ion channel	reviewed	glvI	-	-	-	-	-
P9WPY7	BXGT024294	Argininosuccinate lyase	reviewed	argH	-	-	-	-	-
E9AE57	BXGT003165	Fumarate hydratase 2	reviewed	FH2	-	-	-	-	-
A0A077EBQ3	BXGT025927	Aspartate ammonia-lyase	unreviewed	BD94_1127	-	-	-	-	-
Q9Z2X8	BXGT022415	Kelch-like ECH-associated protein 1	reviewed	Keap1	-	-	-	-	-

Binding DB

26122

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT002006	Lysine-specific demethylase 4E	reviewed		KDM4E	-	1600000	-	-
reviewed	BXGT022418	Methyl-accepting chemotaxis protein NahY	reviewed		nahY	-	-	17000	-
reviewed	BXGT018912	Solute carrier family 22 member 6	reviewed		Slc22a6	616595	-	-	-
reviewed	BXGT017282	Solute carrier family 22 member 20	reviewed		Slc22a20	>31622777	-	-	-
reviewed	BXGT020425	Egl nine homolog 1	reviewed		EGLN1	-	220000	-	-
reviewed	BXGT020425	Egl nine homolog 1	reviewed		EGLN1	-	-	200000	-
reviewed	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	reviewed		FTO	-	150000	-	-

CHEMBL

CHEMBL503160

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q8TDS4	BXGT018812	Hydroxycarboxylic acid receptor 2	reviewed	-	HCAR2	Activity	'='	10	%
Q9C0B1	BXGT020209	Alpha-ketoglutarate-dependent dioxygenase FTO	reviewed	-	FTO	IC50	'='	150000	nM
P00784	BXGT005655	Papain	reviewed	-		Inhibition	-	-	-
Q9GZT9	BXGT020425	Egl nine homolog 1	reviewed	-	EGLN1	Kd	'='	200000	nM
Q80UJ1	BXGT017282	Solute carrier family 22 member 20	reviewed	-	Slc22a20	Ki	'>'	30000000	nM
P00915	BXGT005689	Carbonic anhydrase 1	reviewed	-	CA1	Kinact	'='	395	uM
Q9GZT9	BXGT020425	Egl nine homolog 1	reviewed	-	EGLN1	IC50	'='	19000	nM
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	reviewed	-	APEX1	Potency	-	39810	nM
Q96QE3	BXGT019718	ATPase family AAA domain-containing protein 5	reviewed	-	ATAD5	Potency	-	32629	nM
Q8VC69	BXGT018912	Solute carrier family 22 member 6	reviewed	-	Slc22a6	Ki	'='	610000	nM
P00918	BXGT005690	Carbonic anhydrase 2	reviewed	-	CA2	Kinact	'='	10	uM
P35218	BXGT009796	Carbonic anhydrase 5A, mitochondrial	reviewed	-	CA5A	Kinact	'='	97	nM
Q80UJ1	BXGT017282	Solute carrier family 22 member 20	reviewed	-	Slc22a20	Ki	'>'	31622776	nM
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	reviewed	Enzyme	NFE2L2	Potency	-	421	nM
B2GV46	BXGT001957	Free fatty acid receptor 3	reviewed	-	Ffar3	EC50	-	-	-
Q8VC69	BXGT018912	Solute carrier family 22 member 6	reviewed	-	Slc22a6	Ki	'='	616595	nM
Q9GZT9	BXGT020425	Egl nine homolog 1	reviewed	-	EGLN1	Inhibition	'='	25	%
P16473	BXGT008234	Thyrotropin receptor	reviewed	G-protein coupled receptor	TSHR	Potency	'='	3981	nM
Q9Y2D0	BXGT022229	Carbonic anhydrase 5B, mitochondrial	reviewed	-	CA5B	Kinact	'='	90	nM
Q9GZT9	BXGT020425	Egl nine homolog 1	reviewed	-	EGLN1	IC50	'='	220000	nM
P83916	BXGT012025	Chromobox protein homolog 1	reviewed	Epigenetic regulator	CBX1	Potency	-	3162	nM
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	920	nM
Q16798	BXGT013672	NADP-dependent malic enzyme, mitochondrial	reviewed	Enzyme	ME3	Activity	'='	0	mM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00040	Pepper (C. annuum)	Capsicum annuum	Vegetables
BXGF00081	Fig	Ficus carica	Fruits
BXGF00086	Sunflower	Helianthus annuus	Herbs and Spices
BXGF00128	Passion fruit	Passiflora edulis	Fruits
BXGF00141	Common pea	Pisum sativum	Pulses
BXGF00402	Opium poppy	Papaver somniferum	Herbs and Spices
BXGF00858	Euphorbia antiquorum	Euphorbia antiquorum	Medicinal Plant
BXGF00874	Castanopsis hystrix	Castanopsis hystrix	Medicinal Plant
BXGF00883	Chrozophora prostrata	Chrozophora prostrata	Medicinal Plant
BXGF00965	Othonna cylindrica	Othonna cylindrica	Others
BXGF01009	Dipsacus asper	Dipsacus asper	Others
BXGF01046	Coutarea latifolia	Coutarea latifolia	Others
BXGF01090	Rivina humilis	Rivina humilis	Medicinal Plant
BXGF01103	Euclea natalensis	Euclea natalensis	Medicinal Plant
BXGF01140	Angelica gigas	Angelica gigas	Medicinal Plant
BXGF01171	Duguetia calycina	Duguetia calycina	Human Edible Plant
BXGF01191	Artemisia laciniata	Artemisia laciniata	Medicinal Plant
BXGF01195	Callitris macleayana	Callitris macleayana	Others
BXGF01233	Citrus hassaku	Citrus hassaku	Others
BXGF01238	Morus australis	Morus australis	Medicinal Plant
BXGF01288	Sicana odorifera	Sicana odorifera	Human Edible Plant
BXGF01357	Ampelopsis japonica	Ampelopsis japonica	Medicinal Plant
BXGF01371	Eriostemon spicatus	Eriostemon spicatus	Others
BXGF01397	Euphorbia sieboldiana	Euphorbia sieboldiana	Medicinal Plant
BXGF01402	Phalaris canariensis	Phalaris canariensis	Medicinal Plant
BXGF01467	Torreya fargesii var. yunnanensis	Torreya fargesii var. yunnanensis	Medicinal Plant
BXGF01484	Othonna intermedia	Othonna intermedia	Others
BXGF01492	Jacaranda chelonia	Jacaranda chelonia	Others
BXGF01495	Pleione yunnanensis	Pleione yunnanensis	Others
BXGF01512	Payena lucida	Payena lucida	Medicinal Plant
BXGF01523	Trichoscypha acuminata	Trichoscypha acuminata	Human Edible Plant
BXGF01538	Pteridium aquilinum	Pteridium aquilinum	Medicinal Plant
BXGF01544	Crepidiastrum sonchifolium	Crepidiastrum sonchifolium	Others
BXGF01567	Gaillardia tontalensis	Gaillardia tontalensis	Others
BXGF01602	Thalictrum fauriei	Thalictrum fauriei	Others
BXGF01694	Luvunga scandens	Luvunga scandens	Medicinal Plant
BXGF01713	Cucumis myriocarpus	Cucumis myriocarpus	Medicinal Plant
BXGF01791	Uraria picta	Uraria picta	Medicinal Plant
BXGF01845	Senecio taiwanensis	Senecio taiwanensis	Others
BXGF01911	Bupleurum scorzonerifolium	Bupleurum scorzonerifolium	Medicinal Plant
BXGF01919	Pityrodia ternifolia	Pityrodia ternifolia	Others
BXGF02008	Acronychia acidula	Acronychia acidula	Human Edible Plant
BXGF02034	Erlangea cordifolia	Erlangea cordifolia	Others
BXGF02049	Angelica sinensis	Angelica sinensis	Medicinal Plant
BXGF02062	Glochidion zeylanicum	Glochidion zeylanicum	Others
BXGF02083	Strychnos panamensis	Strychnos panamensis	Others
BXGF02105	Bupleurum aureum	Bupleurum aureum	Others
BXGF02127	Spiraea formosa	Spiraea formosa	Others
BXGF02145	Goupia tomentosa	Goupia tomentosa	Others
BXGF02162	Aglaia cordata	Aglaia cordata	Others
BXGF02275	Trichosanthes kirilowii maxim	Trichosanthes kirilowii maxim	Others
BXGF02317	Krameria parvifolia	Krameria parvifolia	Others
BXGF02331	Syringa pubescens subsp. patula	Syringa pubescens subsp. patula	Others
BXGF02372	Aesculus turbinata	Aesculus turbinata	Medicinal Plant
BXGF02390	Argyreia speciosa	Argyreia speciosa	Medicinal Plant
BXGF02465	Vernonia profuga	Vernonia profuga	Others
BXGF02496	Pleione bulbocodioides	Pleione bulbocodioides	Others
BXGF02499	Cremastra appendiculata	Cremastra appendiculata	Medicinal Plant
BXGF02544	Attalea excelsa	Attalea excelsa	Others
BXGF02578	Artocarpus styracifolius	Artocarpus styracifolius	Human Edible Plant
BXGF02670	Eupatorium recurvans	Eupatorium recurvans	Others
BXGF02779	Swertia chinensis	Swertia chinensis	Medicinal Plant
BXGF02821	Forsythia giraldiana	Forsythia giraldiana	Others
BXGF02892	Dorstenia mannii	Dorstenia mannii	Medicinal Plant
BXGF03079	Glaucium flavum	Glaucium flavum	Medicinal Plant
BXGF03200	Daphniphyllum calycinum	Daphniphyllum calycinum	Medicinal Plant
BXGF03234	Plantago major	Plantago major	Medicinal Plant
BXGF03542	Angylocalyx braunii	Angylocalyx braunii	Others
BXGF03560	Alnus alnobetula	Alnus alnobetula	Others
BXGF03580	Urtica dioica	Urtica dioica	Medicinal Plant
BXGF03592	Wedelia scaberrima	Wedelia scaberrima	Others
BXGF03656	Tripterygium regelii	Tripterygium regelii	Medicinal Plant
BXGF03662	Polygonatum odoratum	Polygonatum odoratum	Medicinal Plant
BXGF03679	Bridelia moonii	Bridelia moonii	Others
BXGF03752	Buglossoides arvensis	Buglossoides arvensis	Medicinal Plant
BXGF03816	Stachyurus himalaicus	Stachyurus himalaicus	Others
BXGF03870	Aloe microstigma	Aloe microstigma	Others
BXGF03948	Salicornia herbacea	Salicornia herbacea	Human Edible Plant
BXGF04023	Putterlickia verrucosa	Putterlickia verrucosa	Others
BXGF04037	Plumbagella micrantha	Plumbagella micrantha	Medicinal Plant
BXGF04186	Sorbus coronata	Sorbus coronata	Others
BXGF04209	Chaenomeles sinensis	Chaenomeles sinensis	Medicinal Plant
BXGF04238	Capsella bursa-pastoris	Capsella bursa-pastoris	Medicinal Plant
BXGF04357	Gentiana dahurica	Gentiana dahurica	Medicinal Plant
BXGF04388	Nephrolepis biserrata	Nephrolepis biserrata	Medicinal Plant
BXGF04419	Pteris plumbea	Pteris plumbea	Others
BXGF04460	Tanacetum parthenifolium	Tanacetum parthenifolium	Others
BXGF04484	Cirsium brevistylum	Cirsium brevistylum	Medicinal Plant
BXGF04842	Angelica acutiloba	Angelica acutiloba	Medicinal Plant
BXGF04845	Sarcandra glabra	Sarcandra glabra	Medicinal Plant
BXGF04875	Bupleurum chinense	Bupleurum chinense	Medicinal Plant
BXGF04889	Pogostemon cablin	Pogostemon cablin	Medicinal Plant
BXGF04904	Samadera indica	Samadera indica	Medicinal Plant
BXGF04981	Bupleurum falcatum	Bupleurum falcatum	Medicinal Plant
BXGF05198	Archidendron lucidum	Archidendron lucidum	Others
BXGF05203	Chlamydomonas reinhardtii	Chlamydomonas reinhardtii	Others
BXGF05222	Veronica persica	Veronica persica	Medicinal Plant
BXGF05252	Michelia longifolia	Michelia longifolia	Others
BXGF05309	Calypogeia integristipula	Calypogeia integristipula	Others
BXGF05406	Tsuga diversifolia	Tsuga diversifolia	Others
BXGF05418	Ligusticum lucidum	Ligusticum lucidum	Others
BXGF05421	Tussilago farfara	Tussilago farfara	Medicinal Plant
BXGF05496	Chrysocoma peduncularis	Chrysocoma peduncularis	Others
BXGF05497	Eupatorium fortunei turcz	Eupatorium fortunei turcz	Others
BXGF05518	Hymenothrix wislizenii	Hymenothrix wislizenii	Others
BXGF05535	Desmodium oxyphyllum	Desmodium oxyphyllum	Others
BXGF05662	Vernonia condensata	Vernonia condensata	Others
BXGF05769	Vismia orientalis	Vismia orientalis	Medicinal Plant
BXGF05774	Psiadia arabica	Psiadia arabica	Others
BXGF05783	Phebalium ambiens	Phebalium ambiens	Others
BXGF05793	Greenwayodendron oliveri	Greenwayodendron oliveri	Others
BXGF05807	Brachychiton populneum	Brachychiton populneum	Others
BXGF05819	Citrus aurantium	Citrus aurantium	Medicinal Plant
BXGF05866	Garcinia pyrifera	Garcinia pyrifera	Others
BXGF05918	Euonymus atropurpurea	Euonymus atropurpurea	Others
BXGF05930	Passiflora foetida	Passiflora foetida	Medicinal Plant
BXGF05994	Corydalis yanhusuo	Corydalis yanhusuo	Medicinal Plant
BXGF06012	Ophryosporus floribundus	Ophryosporus floribundus	Others
BXGF06058	Helichrysum zeyheri	Helichrysum zeyheri	Human Edible Plant
BXGF06074	Artemisia lactiflora	Artemisia lactiflora	Medicinal Plant
BXGF06082	Narthecium asiaticum	Narthecium asiaticum	Others
BXGF06164	Herbertus aduncus	Herbertus aduncus	Others
BXGF06246	Suaeda salsa	Suaeda salsa	Medicinal Plant
BXGF06262	Vernonanthura pinguis	Vernonanthura pinguis	Others
BXGF06295	Catalpa ovata	Catalpa ovata	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}