Showing entry for Kinase suppressor of Ras 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016576
Protein NameKinase suppressor of Ras 2
Uniport IdQ6VAB6
GeneKSR2
Gene Id283455
DomainPkinase_Tyr; SAM_KSR1
Pfam PF07714   PF13543  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0007165 signal transduction
molecular function GO:0005524 ATP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9649948 Signaling downstream of RAS mutants
R-HSA-9656223 Signaling by RAF1 mutants
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0036337 BXGD002598 Schizoaffective Disorder Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202239 BXGD004087 Uric acid measurement (procedure)
C0424574 BXGD008534 Duration of sleep
C0523465 BXGD009209 Serum albumin measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C3548479 BXGD019120 response to bronchodilator
C3897558 BXGD020048 Soluble Interleukin 6 Receptor Measurement
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein