Showing entry for Prolyl 3-hydroxylase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018347
Protein NameProlyl 3-hydroxylase 3
Uniport IdQ8IVL6
GeneP3H3
Gene Id10536
Domain2OG-FeII_Oxy_3
Pfam PF13640  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032964 collagen biosynthetic process
Biological Process GO:0032963 collagen metabolic process
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0017185 peptidyl-lysine hydroxylation
molecular function GO:0005506 iron ion binding
molecular function GO:0031418 L-ascorbic acid binding
molecular function GO:0019797 procollagen-proline 3-dioxygenase activity
cellular component GO:1902494 catalytic complex
cellular component GO:0005783 endoplasmic reticulum
Reactome
Pathway Id Pathway Name
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474290 Collagen formation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006309 BXGD000392 Brucellosis Infections
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0041471 BXGD002926 TYPHUS Infections
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0151936 BXGD003505 Disorder of tendon Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0268342 BXGD005904 Ehlers-Danlos syndrome type 6 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0343758 BXGD007645 Typhus group rickettsial disease Infections
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1568272 BXGD013421 Tendinopathy Musculoskeletal Diseases; Wounds and Injuries
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000288 L-Proline 115.13
BXGC0000764 L-Ascorbic acid 176.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein