Showing entry for Sodium channel subunit beta-4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018357
Protein NameSodium channel subunit beta-4
Uniport IdQ8IWT1
GeneSCN4B
Gene Id6330
DomainV-set
Pfam PF07686  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0086016 AV node cell action potential
Biological Process GO:0086002 cardiac muscle cell action potential involved in contraction
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0086012 membrane depolarization during cardiac muscle cell action potential
Biological Process GO:0010765 positive regulation of sodium ion transport
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:2000649 regulation of sodium ion transmembrane transporter activity
Biological Process GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
Biological Process GO:0035725 sodium ion transmembrane transport
Biological Process GO:0006814 sodium ion transport
molecular function GO:0044325 ion channel binding
molecular function GO:0017080 sodium channel regulator activity
molecular function GO:0005244 voltage-gated ion channel activity
molecular function GO:0005248 voltage-gated sodium channel activity
molecular function GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
cellular component GO:0014704 intercalated disc
cellular component GO:0031226 intrinsic component of plasma membrane
cellular component GO:0001518 voltage-gated sodium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-373760 L1CAM interactions
R-HSA-397014 Muscle contraction
R-HSA-422475 Axon guidance
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5576891 Cardiac conduction
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0035828 BXGD002566 Romano-Ward Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040479 BXGD002870 Torsades de Pointes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085610 BXGD003202 Sinus bradycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0151878 BXGD003495 Prolonged QT interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1141890 BXGD011721 Congenital long QT syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1560305 BXGD013362 Prolonged QTc interval
C1839341 BXGD014370 Abnormal T-wave
C1843687 BXGD014602 ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1963175 BXGD016687 Sinus Bradycardia, CTCAE
C1963217 BXGD016689 Prolonged QTc Interval, CTCAE
C1998313 BXGD016869 T wave alternans
C2108107 BXGD016920 continuous electrocardiogram sinus bradycardia (finding)
C2678484 BXGD017419 Long Qt Syndrome 10 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4013560 BXGD020131 ATRIAL FIBRILLATION, FAMILIAL, 17
C4025797 BXGD021795 Abnormality of prenatal development or birth
C4477077 BXGD022917 Abnormal cardiac exercise stress test
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein