Showing entry for Gamma-secretase subunit APH-1B



                       
General Target Information
BXGT IdBXGT018998
Protein NameGamma-secretase subunit APH-1B
Uniport IdQ8WW43
GeneAPH1B
Gene Id83464
DomainAph-1
Pfam PF06105  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04330 Notch signaling pathway
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0031293 membrane protein intracellular domain proteolysis
Biological Process GO:0007220 Notch receptor processing
Biological Process GO:0035333 Notch receptor processing, ligand-dependent
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0043085 positive regulation of catalytic activity
Biological Process GO:0016485 protein processing
molecular function GO:0004175 endopeptidase activity
molecular function GO:0008233 peptidase activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0010008 endosome membrane
cellular component GO:0070765 gamma-secretase complex
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0030133 transport vesicle
Reactome
Pathway Id Pathway Name
R-HSA-1236394 Signaling by ERBB4
R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1266738 Developmental Biology
R-HSA-157118 Signaling by NOTCH
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-193692 Regulated proteolysis of p75NTR
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-1980143 Signaling by NOTCH1
R-HSA-1980145 Signaling by NOTCH2
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-205043 NRIF signals cell death from the nucleus
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-392499 Metabolism of proteins
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-422475 Axon guidance
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-73887 Death Receptor Signalling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9012852 Signaling by NOTCH3
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-9013694 Signaling by NOTCH4
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-HSA-9017802 Noncanonical activation of NOTCH3
R-HSA-9675108 Nervous system development
R-HSA-977225 Amyloid fiber formation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0017654 BXGD001136 Glomerular Filtration Rate
C0027092 BXGD001971 Myopia Eye Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0852733 BXGD010952 Completed Suicide
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1861735 BXGD016071 Dementia, familial Danish Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Mental Disorders; Otorhinolaryngologic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2363741 BXGD017100 HIV-1 infection
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000663 Papain 206.28
BXGC0021052 Uscharin 587.26
BXGC0033727 Calotropin 532.27
BXGC0043920 Ursocholanic Acid 360.3
BXGC0052647 Asclepin 574.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein