Showing entry for Papain


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000663
Compound NamePapain
Structure
FormulaC13H18O2
InchiKeyHEFNNWSXXWATRW-UHFFFAOYSA-N
SMILESCC(C)CC1=CC=C(C=C1)C(C)C(O)=O
InchiInChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
IUPAC2-[4-(2-methylpropyl)phenyl]propanoic acid
Molecular Weight206.28
Pubchem Id3672
Chembl IdCHEMBL521
Targets of Information Source
DrugBank DB01050
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 approved inhibitor
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 approved inhibitor
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 approved modulator
P07204 BXGT006567 Thrombomodulin reviewed - THBD approved inducer
P12104 BXGT007773 Fatty acid-binding protein, intestinal reviewed - FABP2 approved binder
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG approved activator
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator reviewed Ion channel CFTR approved inhibitor
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha reviewed Nuclear receptor PPARA approved activator
P07359 BXGT006612 Platelet glycoprotein Ib alpha chain reviewed Receptor GP1BA approved inducer
P31151 BXGT009510 Protein S100-A7 reviewed Calcium-binding protein S100A7 approved inducer
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50009859
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 5900 - - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 9900 - - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 7600 - - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 7200 - - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 >10000 - - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 4800 - - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 48 - - -
reviewed BXGT007773 Fatty acid-binding protein, intestinal reviewed FABP2 263500 - - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 4000 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 8000 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 7600 - -
reviewed BXGT010317 Caspase-3 reviewed Enzyme CASP3 - >6.6e+4 - -
reviewed BXGT010724 Caspase-4 reviewed Enzyme CASP4 - 8800 - -
reviewed BXGT010902 Caspase-5 reviewed Enzyme CASP5 - 8100 - -
reviewed BXGT011111 Caspase-9 reviewed Enzyme CASP9 - 4900 - -
reviewed BXGT012211 Fatty-acid amide hydrolase 1 reviewed Faah - 134000 - -
reviewed BXGT012211 Fatty-acid amide hydrolase 1 reviewed Faah - 163000 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 1060 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 11100 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 3000 - -
reviewed BXGT012834 Prostaglandin G/H synthase 2 reviewed Ptgs2 - 860 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 26000 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 30000 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 14000 - -
reviewed BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 - 17000 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 100 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 25000 - -
reviewed BXGT007738 Cytochrome P450 2C9 reviewed CYP2C9 50000 - - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 10100 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 4300 - -
reviewed BXGT011858 Prostaglandin G/H synthase 2 reviewed PTGS2 - 1100 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 2900 - -
reviewed BXGT005057 Bile salt export pump reviewed Abcb11 - 290900 - -
reviewed BXGT005373 Bile salt export pump reviewed Transporter ABCB11 - 598600 - -
reviewed BXGT010867 Cytochrome P450 2J2 reviewed CYP2J2 - >50000 - -
reviewed BXGT005957 Serum albumin reviewed Alb - - 1470 -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 1100 - -
reviewed BXGT004924 Prostaglandin G/H synthase 1 reviewed PTGS1 - 2900 - -
reviewed BXGT004925 Prostaglandin G/H synthase 2 reviewed PTGS2 - 1100 - -
reviewed BXGT012211 Fatty-acid amide hydrolase 1 reviewed Faah - 240000 - -
reviewed BXGT012211 Fatty-acid amide hydrolase 1 reviewed Faah - >500000 - -
reviewed BXGT012211 Fatty-acid amide hydrolase 1 reviewed Faah - 263027 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 80000 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 12000 - -
reviewed BXGT016082 Prostaglandin G/H synthase 1 reviewed Ptgs1 - 2000 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 6300 - -
reviewed BXGT004051 Prostaglandin-H2 D-isomerase reviewed Ptgds - 13000 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 9000 - -
reviewed BXGT011858 Prostaglandin G/H synthase 2 reviewed PTGS2 - 265500 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 14400 - -
reviewed BXGT010301 Aldo-keto reductase family 1 member C3 reviewed Enzyme AKR1C3 - 33000 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 6200 - -
reviewed BXGT018916 Dehydrogenase/reductase SDR family member 9 reviewed Dhrs9 - 100000 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 6900 - -
reviewed BXGT005956 Serum albumin reviewed ALB - 3000 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 1030000 - -
reviewed BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 - 18000 - -
reviewed BXGT018912 Solute carrier family 22 member 6 reviewed Slc22a6 4700 - - -
reviewed BXGT017282 Solute carrier family 22 member 20 reviewed Slc22a20 1100 - - -
reviewed BXGT004924 Prostaglandin G/H synthase 1 reviewed PTGS1 - 13000 - -
reviewed BXGT011858 Prostaglandin G/H synthase 2 reviewed PTGS2 - 370000 - -
reviewed BXGT004924 Prostaglandin G/H synthase 1 reviewed PTGS1 - 18000 - -
reviewed BXGT011858 Prostaglandin G/H synthase 2 reviewed PTGS2 - 1030000 - -
reviewed BXGT005921 Fatty acid-binding protein, liver reviewed Fabp1 47600 - - -
reviewed BXGT005921 Fatty acid-binding protein, liver reviewed Fabp1 448000 - - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 1400 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 1350 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 9000 - - -
reviewed BXGT011858 Prostaglandin G/H synthase 2 reviewed PTGS2 9000 - - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 36000 - -
reviewed BXGT006400 Prostaglandin G/H synthase 1 reviewed PTGS1 - 5000 - -
reviewed BXGT010535 Solute carrier organic anion transporter family member 1A1 reviewed Slco1a1 126000 - - -
reviewed BXGT004540 Solute carrier organic anion transporter family member 1A4 reviewed Slco1a4 2430000 - - -
reviewed BXGT014891 Solute carrier family 22 member 6 reviewed Transporter SLC22A6 - 8000 - -
reviewed BXGT018794 Solute carrier family 22 member 8 reviewed Transporter SLC22A8 1170000 - - -
reviewed BXGT004543 Solute carrier family 22 member 6 reviewed Slc22a6 3500 - - -
CHEMBL CHEMBL521
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 1100 nM
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki '=' 50000 nM
P47824 BXGT010589 P2X purinoceptor 1 reviewed - P2rx1 Inhibition - - -
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Ki '=' 1 nM
P46720 BXGT010535 Solute carrier organic anion transporter family member 1A1 reviewed - Slco1a1 Ki '=' 126000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 8000 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 Change '>' 50 uM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 25530 nM
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Drug metabolism - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Drug metabolism - - -
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 Inhibition - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 1400 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Drug metabolism - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
Q8TCC7 BXGT018794 Solute carrier family 22 member 8 reviewed Transporter SLC22A8 Activity - - -
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 12000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 1100 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 26000 nM
P02692 BXGT005921 Fatty acid-binding protein, liver reviewed - Fabp1 Ki '=' 448000 nM
P11308 BXGT007684 Transcriptional regulator ERG reviewed Transcription factor ERG Potency - 11220 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 0 pm/min/mg
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 2900 nM
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity '=' 0 pm/min/mg
O62664 BXGT004924 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 2900 nM
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 8492 nM
O62664 BXGT004924 Prostaglandin G/H synthase 1 reviewed - PTGS1 Activity - - -
P21398 BXGT008645 Amine oxidase [flavin-containing] A reviewed - MAOA Activity - - -
O35913 BXGT004540 Solute carrier organic anion transporter family member 1A4 reviewed - Slco1a4 Ki '=' 2430000 nM
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity - - -
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '>' 10000 nM
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Activity - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition - - -
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 0 pm/min/mg
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 100 nM
P36537 BXGT009924 UDP-glucuronosyltransferase 2B10 reviewed - UGT2B10 Activity '=' 0 pm/min/mg
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 Inhibition '=' 87 %
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 1030000 nM
P06133 BXGT006414 UDP-glucuronosyltransferase 2B4 reviewed - UGT2B4 Activity '=' 0 pm/min/mg
Q80UJ1 BXGT017282 Solute carrier family 22 member 20 reviewed - Slc22a20 Ki '=' 1100 nM
P56560 BXGT011180 Amine oxidase [flavin-containing] B reviewed - MAOB Activity - - -
Q4U2R8 BXGT014891 Solute carrier family 22 member 6 reviewed Transporter SLC22A6 Activity - - -
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah IC50 '=' 263026 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
Q4U2R8 BXGT014891 Solute carrier family 22 member 6 reviewed Transporter SLC22A6 Activity '=' 47 %
O62664 BXGT004924 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 18000 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
O09114 BXGT004051 Prostaglandin-H2 D-isomerase reviewed - Ptgds IC50 '=' 13000 nM
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 Change '=' 0 uM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 Change '=' 0 uM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P0DTE4 BXGT022286 UDP-glucuronosyltransferase 2A1 reviewed - UGT2A1 Activity - - -
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Activity - - -
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Vmax '=' 88 pmol/min/mg protein
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 '=' 17000 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 47 %
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '=' 100 %
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 598600 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 Inhibition '=' 54 %
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 9000 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ratio '=' 1 -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ratio '=' 1 -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition - - -
Q9NSA0 BXGT021202 Solute carrier family 22 member 11 reviewed Transporter SLC22A11 Activity - - -
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 Ki '=' 9000 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Inhibition - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 29092 nM
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 0 pm/min/mg
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 30000 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 5000 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 18000 nM
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 Activity - - -
Q8VD48 BXGT018916 Dehydrogenase/reductase SDR family member 9 reviewed - Dhrs9 Inhibition '=' 70 %
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 Activity '=' 79 %
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Ki '=' 9000 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition '=' 53 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Inhibition '=' 71 %
O62698 BXGT004925 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 1100 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition '=' 96 %
Q8TCC7 BXGT018794 Solute carrier family 22 member 8 reviewed Transporter SLC22A8 Ki '=' 1170000 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache Inhibition '=' 20 %
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Inhibition '>' 70 %
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '>' 70 %
Q80UJ1 BXGT017282 Solute carrier family 22 member 20 reviewed - Slc22a20 Ki '=' 1122 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '=' 40 %
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Activity - - -
P02692 BXGT005921 Fatty acid-binding protein, liver reviewed - Fabp1 Ki '=' 47600 nM
Q4U2R8 BXGT014891 Solute carrier family 22 member 6 reviewed Transporter SLC22A6 IC50 '=' 8000 nM
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P49653 BXGT010723 P2X purinoceptor 2 reviewed - P2rx2 Inhibition - - -
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 1060 nM
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 3000 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Selectivity '=' 0 -
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 Inhibition - - -
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 265500 nM
Q05769 BXGT012834 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 220 nM
P22437 BXGT008766 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '=' 220 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ratio '=' 0 -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ratio '=' 0 -
Q8VD48 BXGT018916 Dehydrogenase/reductase SDR family member 9 reviewed - Dhrs9 IC50 '=' 100000 nM
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 80 pm/min/mg
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 111 %
Q8VC69 BXGT018912 Solute carrier family 22 member 6 reviewed - Slc22a6 Ki '=' 4677 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Inhibition '=' 48 %
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 4300 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 100000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 80000 nM
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Vmax '=' 477 pmol/min/mg protein
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 14000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 100 nM
O14684 BXGT004082 Prostaglandin E synthase reviewed - PTGES Activity '=' 81 %
P02770 BXGT005957 Serum albumin reviewed - Alb Kd '=' 1470 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 15003 nM
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Km '=' 55000 nM
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Drug metabolism - - -
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 SI '=' 2 -
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 SI '=' 2 -
P49810 BXGT010747 Presenilin-2 reviewed Enzyme PSEN2 Inhibition '=' 41 %
Q92542 BXGT019354 Nicastrin reviewed - NCSTN Inhibition '=' 41 %
P49768 BXGT010740 Presenilin-1 reviewed Enzyme PSEN1 Inhibition '=' 41 %
Q8WW43 BXGT018998 Gamma-secretase subunit APH-1B reviewed Enzyme modulator APH1B Inhibition '=' 41 %
Q9NZ42 BXGT021268 Gamma-secretase subunit PEN-2 reviewed - PSENEN Inhibition '=' 41 %
Q96BI3 BXGT019623 Gamma-secretase subunit APH-1A reviewed Enzyme modulator APH1A Inhibition '=' 41 %
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '=' 600 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 600 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 11100 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 6900 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 6200 nM
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 IC50 '=' 512861 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Activity '=' 0 %
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 IC50 '=' 295120 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Activity - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 - - -
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah Inhibition '=' 100 %
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Activity '=' 75 %
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 125892 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 125892 nM
Q8VC69 BXGT018912 Solute carrier family 22 member 6 reviewed - Slc22a6 Ki '=' 4700 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 ID50 '=' 56 mg.kg-1
P42330 BXGT010301 Aldo-keto reductase family 1 member C3 reviewed Enzyme AKR1C3 IC50 '=' 33000 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 21331 nM
O62664 BXGT004924 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 13000 nM
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 370000 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 5 nM
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '=' 2000 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 2000 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Activity '=' 112 %
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
Q9NSA0 BXGT021202 Solute carrier family 22 member 11 reviewed Transporter SLC22A11 Activity '=' 67 %
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Inhibition '=' 6 %
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 290 nM
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Activity '=' 80 %
P70502 BXGT011672 Solute carrier organic anion transporter family member 1A3 reviewed - Slco1a3 Activity - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '=' 6 %
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition '<' 50 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah IC50 '>' 500000 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 14125 nM
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 reviewed - UGT1A7 Activity '=' 0 pm/min/mg
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah IC50 '=' 260000 nM
Q99685 BXGT019948 Monoglyceride lipase reviewed Enzyme MGLL Inhibition - - -
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Activity '=' 130 %
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 36000 nM
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 '>' 10000 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 14400 nM
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Drug metabolism - - -
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 Inhibition '=' 76 %
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Activity - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 98 %
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 6300 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 ED50 '=' 0 ug ml-1
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 ED50 '=' 0 ug ml-1
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 11220 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 4000 nM
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 1030000 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 10100 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' -6 %
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Inhibition '>=' 90 %
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
Q05769 BXGT012834 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 860 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 Inhibition '=' 95 %
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 Inhibition '=' 95 %
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 Activity '=' 103 %
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 1860 nM
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency '=' 223 nM
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Km '=' 230000 nM
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 212 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P08170 BXGT006736 Seed linoleate 13S-lipoxygenase-1 reviewed - LOX1.1 IC50 '=' 200000 nM
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 reviewed Ion channel TRPV1 IC50 - - -
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition '=' 73 %
O75795 BXGT005152 UDP-glucuronosyltransferase 2B17 reviewed - UGT2B17 Activity - - -
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 Activity '=' 31 %
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P0DTE4 BXGT022286 UDP-glucuronosyltransferase 2A1 reviewed - UGT2A1 Activity '=' 68 pm/min/mg
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 0 pm/min/mg
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
O88909 BXGT005288 Solute carrier family 22 member 8 reviewed - Slc22a8 Activity '=' 80 %
O70127 BXGT005057 Bile salt export pump reviewed - Abcb11 IC50 '=' 290900 nM
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 Activity - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Inhibition '=' 70 %
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 1350 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition '=' 100 %
P97612 BXGT012211 Fatty-acid amide hydrolase 1 reviewed - Faah IC50 '=' 240000 nM
P02769 BXGT005956 Serum albumin reviewed - ALB IC50 '=' 3000 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 1337 nM
P51577 BXGT010863 P2X purinoceptor 4 reviewed - P2rx4 Inhibition - - -
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Inhibition '=' 13 %
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 pH50 '=' 6 -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
Q80UJ1 BXGT017282 Solute carrier family 22 member 20 reviewed - Slc22a20 Vmax '=' 0 pmol/hr
Q8VC69 BXGT018912 Solute carrier family 22 member 6 reviewed - Slc22a6 Vmax '=' 1 pmol/hr
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 14500 nM
O35956 BXGT004543 Solute carrier family 22 member 6 reviewed - Slc22a6 Ki '=' 3500 nM
O35956 BXGT004543 Solute carrier family 22 member 6 reviewed - Slc22a6 Activity - - -
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Drug metabolism - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG FC '=' 5 -
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Drug metabolism - - -
O95069 BXGT005348 Potassium channel subfamily K member 2 reviewed Ion channel KCNK2 Activity '=' 10 %
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 '=' 25000 nM
Q62962 BXGT016051 Acid-sensing ion channel 2 reviewed - Asic2 Imax '=' 50 %
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 Imax '=' 98 %
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 IC50 '=' 295000 nM
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P02768 BXGT005955 Serum albumin reviewed Transporter ALB Activity '=' 70 %
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 72800 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '=' 90 %
O35240 BXGT004519 Acid-sensing ion channel 3 reviewed - Asic3 IC50 '=' 512861 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 1080 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 789000 nM
O14684 BXGT004082 Prostaglandin E synthase reviewed - PTGES ED50 '=' 0 ug ml-1
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 IC50 '=' 513000 nM
P42330 BXGT010301 Aldo-keto reductase family 1 member C3 reviewed Enzyme AKR1C3 Inhibition '=' 59 %
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 Inhibition '=' 88 %
P51589 BXGT010867 Cytochrome P450 2J2 reviewed - CYP2J2 IC50 '>' 50000 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 1420 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 11220 nM
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 IC50 '=' 135000 nM
P42330 BXGT010301 Aldo-keto reductase family 1 member C3 reviewed Enzyme AKR1C3 IC50 '=' 10000 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 3350 nM
O35240 BXGT004519 Acid-sensing ion channel 3 reviewed - Asic3 Imax '=' 85 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 1258 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Drug metabolism - - -
Q6NXK8 BXGT016433 Acid-sensing ion channel 1 reviewed - Asic1 Inhibition - - -
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Drug metabolism - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Drug metabolism - - -
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Drug metabolism - - -
P79208 BXGT011858 Prostaglandin G/H synthase 2 reviewed - PTGS2 IC50 '=' 1400 nM
P05979 BXGT006400 Prostaglandin G/H synthase 1 reviewed - PTGS1 IC50 '=' 6300 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Drug metabolism - - -
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '>' 100000 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Drug metabolism - - -
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 Inhibition '=' 92 %
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '=' 94 %
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 135000 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 4200 nM
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 IC50 '=' 134896 nM
P55926 BXGT011134 Acid-sensing ion channel 1 reviewed - Asic1 TIME '=' 0 hr
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Drug metabolism - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00041 Papaya Carica papaya Fruits
BXGF00823 Fruits Fruits
BXGF00946 Artemisia montana Artemisia montana Medicinal Plant
BXGF03953 Artemisia princeps Artemisia princeps Medicinal Plant
BXGF04611 Artemisia argyi Artemisia argyi Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease