Showing entry for Alkylated DNA repair protein alkB homolog 8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019628
Protein NameAlkylated DNA repair protein alkB homolog 8
Uniport IdQ96BT7
GeneALKBH8
Gene Id91801
Domain2OG-FeII_Oxy_2; DUF1891; Methyltransf_11
Pfam PF13532   PF09004   PF08241  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0030488 tRNA methylation
Biological Process GO:0002098 tRNA wobble uridine modification
molecular function GO:0016706 2-oxoglutarate-dependent dioxygenase activity
molecular function GO:0005506 iron ion binding
molecular function GO:0016300 tRNA (uracil) methyltransferase activity
molecular function GO:0000049 tRNA binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0016604 nuclear body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-6782315 tRNA modification in the nucleus and cytosol
R-HSA-72306 tRNA processing
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027626 BXGD002005 Neoplasm Invasiveness Pathological Conditions, Signs and Symptoms; Neoplasms
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0152421 BXGD003586 Macrotia
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1305740 BXGD012346 Overbite Stomatognathic Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1827293 BXGD013768 Carcinoma of urinary bladder, invasive Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1836047 BXGD014074 Long face
C1855852 BXGD015554 Abnormally large globe
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002485 2-Oxopentanedioic acid 146.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein