adisease

Showing entry for Sunken eyes

General Disease Information
BXGD Id	BXGD008475
Disease Name	Sunken eyes
Disease CUI Id	C0423224
MeSH Codes	C23 C11 C10
Disease Class Name	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
Semantic Type	Finding
Human Phenotype Ontology Id	HP:0000478
Human Phenotype Ontology Term	Abnormality of the eye
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A4D126	BXGT001208	D-ribitol-5-phosphate cytidylyltransferase	729920	reviewed
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O14764	BXGT004094	Gamma-aminobutyric acid receptor subunit delta	2563	reviewed	Ion channel
O14770	BXGT004095	Homeobox protein Meis2	4212	reviewed	Enzyme
O43497	BXGT004596	Voltage-dependent T-type calcium channel subunit alpha-1G	8913	reviewed	Ion channel
O76039	BXGT005171	Cyclin-dependent kinase-like 5	6792	reviewed	Kinase
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P11274	BXGT007681	Breakpoint cluster region protein	613	reviewed	Enzyme modulator
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P21675	BXGT008678	Transcription initiation factor TFIID subunit 1	6872	reviewed	Kinase
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	5295	reviewed	Kinase
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P32322	BXGT009624	Pyrroline-5-carboxylate reductase 1, mitochondrial	5831	reviewed
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35573	BXGT009850	Glycogen debranching enzyme	178	reviewed	Enzyme
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41229	BXGT010239	Lysine-specific demethylase 5C	8242	reviewed
P42263	BXGT010295	Glutamate receptor 3	2892	reviewed	Ion channel
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P56524	BXGT011176	Histone deacetylase 4	9759	reviewed	Epigenetic regulator
P60891	BXGT011337	Ribose-phosphate pyrophosphokinase 1	5631	reviewed	Kinase
P78504	BXGT011844	Protein jagged-1	182	reviewed
P82279	BXGT011972	Protein crumbs homolog 1	23418	reviewed
Q00604	BXGT012538	Norrin	4693	reviewed
Q01968	BXGT012626	Inositol polyphosphate 5-phosphatase OCRL-1	4952	reviewed	Enzyme
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q09472	BXGT013038	Histone acetyltransferase p300	2033	reviewed
Q12830	BXGT013268	Nucleosome-remodeling factor subunit BPTF	2186	reviewed
Q12882	BXGT013276	Dihydropyrimidine dehydrogenase [NADP(+)]	1806	reviewed	Enzyme
Q13153	BXGT013319	Serine/threonine-protein kinase PAK 1	5058	reviewed	Kinase
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q13303	BXGT013336	Voltage-gated potassium channel subunit beta-2	8514	reviewed	Ion channel
Q13363	BXGT013344	C-terminal-binding protein 1	1487	reviewed	Transcription factor
Q13426	BXGT013353	DNA repair protein XRCC4	7518	reviewed
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13586	BXGT013380	Stromal interaction molecule 1	6786	reviewed
Q13627	BXGT013385	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	1859	reviewed	Kinase
Q15149	BXGT013547	Plectin	5339	reviewed	Cellular structure
Q2M1P5	BXGT014129	Kinesin-like protein KIF7	374654	reviewed
Q4G0J3	BXGT014809	La-related protein 7	51574	reviewed	Nucleic acid binding
Q8IWS0	BXGT018356	PHD finger protein 6	84295	reviewed	Nucleic acid binding
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q96BT7	BXGT019628	Alkylated DNA repair protein alkB homolog 8	91801	reviewed
Q96BZ9	BXGT019629	TBC1 domain family member 20	128637	reviewed
Q96D31	BXGT019635	Calcium release-activated calcium channel protein 1	84876	reviewed	Ion channel
Q99250	BXGT019913	Sodium channel protein type 2 subunit alpha	6326	reviewed	Ion channel
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9GZZ9	BXGT020430	Ubiquitin-like modifier-activating enzyme 5	79876	reviewed	Enzyme
Q9H4W6	BXGT020478	Transcription factor COE3	253738	reviewed
Q9NSD9	BXGT021206	Phenylalanine--tRNA ligase beta subunit	10056	reviewed	Enzyme
Q9NSE4	BXGT021207	Isoleucine--tRNA ligase, mitochondrial	55699	reviewed	Enzyme
Q9NYG8	BXGT021257	Potassium channel subfamily K member 4	50801	reviewed	Ion channel
Q9UHD8	BXGT021698	Septin-9	10801	reviewed	Enzyme modulator
Q9UHX1	BXGT021707	Poly(U)-binding-splicing factor PUF60	22827	reviewed
Q9UPT6	BXGT021801	C-Jun-amino-terminal kinase-interacting protein 3	23162	reviewed	Enzyme modulator
Q9UQD0	BXGT021811	Sodium channel protein type 8 subunit alpha	6334	reviewed	Ion channel
Q96C86	BXGT022803	m7GpppX diphosphatase	28960	reviewed	Enzyme
Q5FWF4	BXGT023211	DNA annealing helicase and endonuclease ZRANB3	84083	reviewed
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
Q9NPF4	BXGT024113	Probable tRNA N6-adenosine threonylcarbamoyltransferase	55644	reviewed	Enzyme
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
P49366	BXGT025175	Deoxyhypusine synthase	1725	reviewed
Q05086	BXGT025648	Ubiquitin-protein ligase E3A	7337	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}