Showing entry for Sphingosine 1-phosphate receptor 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019927
Protein NameSphingosine 1-phosphate receptor 3
Uniport IdQ99500
GeneS1PR3
Gene Id1903
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0001816 cytokine production
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0006954 inflammatory response
Biological Process GO:1903141 negative regulation of establishment of endothelial barrier
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0032651 regulation of interleukin-1 beta production
Biological Process GO:0019222 regulation of metabolic process
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0005178 integrin binding
molecular function GO:0008289 lipid binding
molecular function GO:0038036 sphingosine-1-phosphate receptor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors
R-HSA-500792 GPCR ligand binding
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9009391 Extra-nuclear estrogen signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0014474 BXGD000917 Ependymoma Neoplasms
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024530 BXGD001783 Malaria Infections
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0205770 BXGD004121 Choroid Plexus Papilloma Neoplasms; Nervous System Diseases
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0220756 BXGD004338 Niemann-Pick Disease, Type C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684256 BXGD009791 Bacterial sepsis Pathological Conditions, Signs and Symptoms; Infections
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0746731 BXGD010148 Acute myocardial ischemia Cardiovascular Diseases
C0748355 BXGD010195 Acute respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1719672 BXGD013659 Severe Sepsis Pathological Conditions, Signs and Symptoms; Infections
C1858556 BXGD015805 OVERLAP CONNECTIVE TISSUE DISEASE Eye Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3160909 BXGD018497 Autoimmune arthritis
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4049446 BXGD021933 Neointimal hyperplasia
C4534309 BXGD023217 Acute lung injury/Acute respiratory distress syndrome (ARDS)
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0052798 5-Meo-Dmt 218.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein