adisease

Showing entry for Bone Diseases

General Disease Information
BXGD Id	BXGD000352
Disease Name	Bone Diseases
Disease CUI Id	C0005940
MeSH Codes	C05
Disease Class Name	Musculoskeletal Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00255	BXGT003903	Menin	4221	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O14924	BXGT004111	Regulator of G-protein signaling 12	6002	reviewed
O15357	BXGT004156	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	3636	reviewed
O43157	BXGT004572	Plexin-B1	5364	reviewed
O43557	BXGT004600	Tumor necrosis factor ligand superfamily member 14	8740	reviewed	Signaling
O43612	BXGT004605	Orexin	3060	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60931	BXGT004911	Cystinosin	1497	reviewed
O75365	BXGT005115	Protein tyrosine phosphatase type IVA 3	11156	reviewed
O75581	BXGT005136	Low-density lipoprotein receptor-related protein 6	4040	reviewed
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O95407	BXGT005380	Tumor necrosis factor receptor superfamily member 6B	8771	reviewed
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02008	BXGT005832	Hemoglobin subunit zeta	3050	reviewed
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02818	BXGT005969	Osteocalcin	632	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P05186	BXGT006338	Alkaline phosphatase, tissue-nonspecific isozyme	249	reviewed	Enzyme
P05187	BXGT006339	Alkaline phosphatase, placental type	250	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06241	BXGT006429	Tyrosine-protein kinase Fyn	2534	reviewed	Kinase
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P07099	BXGT006546	Epoxide hydrolase 1	2052	reviewed
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P08100	BXGT006725	Rhodopsin	6010	reviewed	G-protein coupled receptor
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08700	BXGT006816	Interleukin-3	3562	reviewed
P08865	BXGT006832	40S ribosomal protein SA	3921	reviewed	Nucleic acid binding
P09237	BXGT006874	Matrilysin	4316	reviewed	Enzyme
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P11309	BXGT007685	Serine/threonine-protein kinase pim-1	5292	reviewed	Kinase
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P13497	BXGT007915	Bone morphogenetic protein 1	649	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14324	BXGT008005	Farnesyl pyrophosphate synthase	2224	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15941	BXGT008176	Mucin-1	4582	reviewed
P16157	BXGT008203	Ankyrin-1	286	reviewed
P17342	BXGT008302	Atrial natriuretic peptide receptor 3	4883	reviewed
P17861	BXGT008348	X-box-binding protein 1	7494	reviewed
P18075	BXGT008375	Bone morphogenetic protein 7	655	reviewed	Signaling
P18433	BXGT008403	Receptor-type tyrosine-protein phosphatase alpha	5786	reviewed	Enzyme
P18827	BXGT008427	Syndecan-1	6382	reviewed	Extracellular structure
P19971	BXGT008537	Thymidine phosphorylase	1890	reviewed	Enzyme
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22736	BXGT008800	Nuclear receptor subfamily 4 group A member 1	3164	reviewed	Nuclear receptor
P23458	BXGT008868	Tyrosine-protein kinase JAK1	3716	reviewed	Kinase
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P27037	BXGT009153	Activin receptor type-2A	92	reviewed	Kinase
P28222	BXGT009238	5-hydroxytryptamine receptor 1B	3351	reviewed	G-protein coupled receptor
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28562	BXGT009270	Dual specificity protein phosphatase 1	1843	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35398	BXGT009825	Nuclear receptor ROR-alpha	6095	reviewed	Nuclear receptor
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P35610	BXGT009855	Sterol O-acyltransferase 1	6646	reviewed	Enzyme
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P40967	BXGT010212	Melanocyte protein PMEL	6490	reviewed	Signaling
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49419	BXGT010705	Alpha-aminoadipic semialdehyde dehydrogenase	501	reviewed	Enzyme
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P55072	BXGT011103	Transitional endoplasmic reticulum ATPase	7415	reviewed
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P61604	BXGT011380	10 kDa heat shock protein, mitochondrial	3336	reviewed	Chaperone
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P78504	BXGT011844	Protein jagged-1	182	reviewed
P78556	BXGT011849	C-C motif chemokine 20	6364	reviewed	Signaling
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	4791	reviewed	Transcription factor
Q01082	BXGT012567	Spectrin beta chain, non-erythrocytic 1	6711	reviewed
Q01974	BXGT012628	Tyrosine-protein kinase transmembrane receptor ROR2	4920	reviewed	Kinase
Q02750	BXGT012662	Dual specificity mitogen-activated protein kinase kinase 1	5604	reviewed	Kinase
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q04760	BXGT012782	Lactoylglutathione lyase	2739	reviewed
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q07954	BXGT012950	Prolow-density lipoprotein receptor-related protein 1	4035	reviewed
Q07973	BXGT012952	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	1591	reviewed	Enzyme
Q12918	BXGT013280	Killer cell lectin-like receptor subfamily B member 1	3820	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13526	BXGT013369	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5300	reviewed
Q14114	BXGT013441	Low-density lipoprotein receptor-related protein 8	7804	reviewed
Q14623	BXGT013490	Indian hedgehog protein	3549	reviewed
Q14680	BXGT013499	Maternal embryonic leucine zipper kinase	9833	reviewed	Kinase
Q15020	BXGT013522	Squamous cell carcinoma antigen recognized by T-cells 3	9733	reviewed	Nucleic acid binding
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q32P28	BXGT014324	Prolyl 3-hydroxylase 1	64175	reviewed	Extracellular structure
Q6P5Z2	BXGT016454	Serine/threonine-protein kinase N3	29941	reviewed	Kinase
Q7KZF4	BXGT016989	Staphylococcal nuclease domain-containing protein 1	27044	reviewed	Transcription factor
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q92854	BXGT019385	Semaphorin-4D	10507	reviewed	Signaling
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96SW2	BXGT019743	Protein cereblon	51185	reviewed	Enzyme
Q99500	BXGT019927	Sphingosine 1-phosphate receptor 3	1903	reviewed	G-protein coupled receptor
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99685	BXGT019948	Monoglyceride lipase	11343	reviewed	Enzyme
Q9H0A0	BXGT020434	RNA cytidine acetyltransferase	55226	reviewed
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9HCE7	BXGT020532	E3 ubiquitin-protein ligase SMURF1	57154	reviewed	Enzyme
Q9NRA0	BXGT021183	Sphingosine kinase 2	56848	reviewed	Kinase
Q9P2W7	BXGT021306	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	27087	reviewed	Enzyme
Q9ULW0	BXGT021766	Targeting protein for Xklp2	22974	reviewed	Cellular structure
Q9UPN3	BXGT021797	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5	23499	reviewed	Cellular structure
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y5X0	BXGT022305	Sorting nexin-10	29887	reviewed
Q9UK05	BXGT023094	Growth/differentiation factor 2	2658	reviewed	Signaling
P17752	BXGT023118	Tryptophan 5-hydroxylase 1	7166	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q9Y294	BXGT023981	Histone chaperone ASF1A	25842	reviewed	Nucleic acid binding
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
P20809	BXGT025043	Interleukin-11	3589	reviewed
Q9GZV5	BXGT025439	WW domain-containing transcription regulator protein 1	25937	reviewed	Enzyme modulator
O43613	BXGT025666	Orexin receptor type 1	3061	reviewed	G-protein coupled receptor
P51798	BXGT026083	H(+)/Cl(-) exchange transporter 7	1186	reviewed	Ion channel
Q8N122	BXGT026091	Regulatory-associated protein of mTOR	57521	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}