adisease

Showing entry for Severe Sepsis

General Disease Information
BXGD Id	BXGD013659
Disease Name	Severe Sepsis
Disease CUI Id	C1719672
MeSH Codes	C23 C01
Disease Class Name	Pathological Conditions, Signs and Symptoms; Infections
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14672	BXGT004081	Disintegrin and metalloproteinase domain-containing protein 10	102	reviewed
O15123	BXGT004130	Angiopoietin-2	285	reviewed	Signaling
O43521	BXGT004598	Bcl-2-like protein 11	10018	reviewed
O43678	BXGT004613	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	4695	reviewed	Enzyme
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O75489	BXGT005131	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	4722	reviewed
O95405	BXGT005379	Zinc finger FYVE domain-containing protein 9	9372	reviewed
O95445	BXGT005381	Apolipoprotein M	55937	reviewed
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00751	BXGT005643	Complement factor B	629	reviewed
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01903	BXGT005814	HLA class II histocompatibility antigen, DR alpha chain	3122	reviewed	Immune response
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02760	BXGT005948	Protein AMBP	259	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04070	BXGT006143	Vitamin K-dependent protein C	5624	reviewed	Enzyme
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P08311	BXGT006762	Cathepsin G	1511	reviewed	Enzyme
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09238	BXGT006875	Stromelysin-2	4319	reviewed	Enzyme
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P0DMV8	BXGT007509	Heat shock 70 kDa protein 1A	3304	reviewed
P0DMV9	BXGT007510	Heat shock 70 kDa protein 1B	3304	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10646	BXGT007598	Tissue factor pathway inhibitor	7035	reviewed	Enzyme modulator
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	3309	reviewed
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P12314	BXGT007798	High affinity immunoglobulin gamma Fc receptor I	2209	reviewed	Cell adhesion
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15144	BXGT008087	Aminopeptidase N	290	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P18827	BXGT008427	Syndecan-1	6382	reviewed	Extracellular structure
P19429	BXGT008479	Troponin I, cardiac muscle	7137	reviewed	Cellular structure
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20160	BXGT008548	Azurocidin	566	reviewed	Enzyme
P25025	BXGT009006	C-X-C chemokine receptor type 2	3579	reviewed	G-protein coupled receptor
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29274	BXGT009327	Adenosine receptor A2a	135	reviewed	G-protein coupled receptor
P29275	BXGT009328	Adenosine receptor A2b	136	reviewed	G-protein coupled receptor
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30046	BXGT009396	D-dopachrome decarboxylase	1652	reviewed	Enzyme
P34931	BXGT009771	Heat shock 70 kDa protein 1-like	3305	reviewed
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P40933	BXGT010209	Interleukin-15	3600	reviewed
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P43489	BXGT010394	Tumor necrosis factor receptor superfamily member 4	7293	reviewed
P49662	BXGT010724	Caspase-4	837	reviewed	Enzyme
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P51878	BXGT010902	Caspase-5	838	reviewed	Enzyme
P54652	BXGT011064	Heat shock-related 70 kDa protein 2	3306	reviewed
P55957	BXGT011137	BH3-interacting domain death agonist	637	reviewed
P59666	BXGT011273	Neutrophil defensin 3	1668	reviewed
P60022	BXGT011285	Beta-defensin 1	1672	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P81172	BXGT011935	Hepcidin	57817	reviewed
Q07011	BXGT012912	Tumor necrosis factor receptor superfamily member 9	3604	reviewed
Q07108	BXGT012919	Early activation antigen CD69	969	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14393	BXGT013466	Growth arrest-specific protein 6	2621	reviewed	Extracellular structure
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15582	BXGT013581	Transforming growth factor-beta-induced protein ig-h3	7045	reviewed	Signaling
Q15746	BXGT013591	Myosin light chain kinase, smooth muscle	4638	reviewed	Kinase
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q76LX8	BXGT016870	A disintegrin and metalloproteinase with thrombospondin motifs 13	11093	reviewed	Enzyme
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q99500	BXGT019927	Sphingosine 1-phosphate receptor 3	1903	reviewed	G-protein coupled receptor
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9GZT9	BXGT020425	Egl nine homolog 1	54583	reviewed
Q9NP99	BXGT021148	Triggering receptor expressed on myeloid cells 1	54210	reviewed
Q9NYA1	BXGT021254	Sphingosine kinase 1	8877	reviewed	Kinase
Q9UNN8	BXGT021791	Endothelial protein C receptor	10544	reviewed	Enzyme modulator
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y5S8	BXGT022302	NADPH oxidase 1	27035	reviewed
Q9Y5Y9	BXGT022309	Sodium channel protein type 10 subunit alpha	6336	reviewed	Ion channel
Q9Y616	BXGT022313	Interleukin-1 receptor-associated kinase 3	11213	reviewed	Kinase
P19875	BXGT023294	C-X-C motif chemokine 2	2920	reviewed	Signaling
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q969H8	BXGT025606	Myeloid-derived growth factor	56005	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}