Showing entry for Lysine-specific demethylase 5D


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020183
Protein NameLysine-specific demethylase 5D
Uniport IdQ9BY66
GeneKDM5D
Gene Id8284
DomainARID; JmjC; JmjN; PHD; PLU-1; zf-C5HC2
Pfam PF01388   PF02373   PF02375   PF00628   PF08429   PF02928  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0034720 histone H3-K4 demethylation
Biological Process GO:0060765 regulation of androgen receptor signaling pathway
molecular function GO:0050681 androgen receptor binding
molecular function GO:0051213 dioxygenase activity
molecular function GO:0003677 DNA binding
molecular function GO:0032452 histone demethylase activity
molecular function GO:0032453 histone demethylase activity (H3-K4 specific)
molecular function GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)
molecular function GO:0046872 metal ion binding
cellular component GO:0001650 fibrillar center
cellular component GO:0035097 histone methyltransferase complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-3214842 HDMs demethylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0729353 BXGD009924 Subfertility Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0745287 BXGD010125 infertility tubal factor
C1269955 BXGD012005 Tumor Cell Invasion
C1334978 BXGD012753 Non-Hereditary Clear Cell Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1839071 BXGD014356 Spermatogenic Failure, Nonobstructive, Y-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000764 L-Ascorbic acid 176.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein