Showing entry for Osteoarthritis, Knee


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD008400
Disease NameOsteoarthritis, Knee
Disease CUI IdC0409959
MeSH Codes C05  
Disease Class NameMusculoskeletal Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0040064   HP:0000924  
Human Phenotype Ontology TermAbnormality of limbs; Abnormality of the skeletal system
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00512 BXGT003933 B-cell CLL/lymphoma 9 protein 607 reviewed
O14684 BXGT004082 Prostaglandin E synthase 9536 reviewed
O14788 BXGT004100 Tumor necrosis factor ligand superfamily member 11 8600 reviewed Signaling
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15455 BXGT004171 Toll-like receptor 3 7098 reviewed Receptor
O60240 BXGT004860 Perilipin-1 5346 reviewed
O60547 BXGT004881 GDP-mannose 4,6 dehydratase 2762 reviewed Enzyme
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O75173 BXGT005105 A disintegrin and metalloproteinase with thrombospondin motifs 4 9507 reviewed Enzyme
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 8856 reviewed Nuclear receptor
O75751 BXGT005150 Solute carrier family 22 member 3 6581 reviewed Transporter
O94788 BXGT005333 Retinal dehydrogenase 2 8854 reviewed Enzyme
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02458 BXGT005879 Collagen alpha-1(II) chain 1280 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02818 BXGT005969 Osteocalcin 632 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04003 BXGT006124 C4b-binding protein alpha chain 722 reviewed
P04156 BXGT006156 Major prion protein 5621 reviewed
P04440 BXGT006216 HLA class II histocompatibility antigen, DP beta 1 chain 3115 reviewed Immune response
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04839 BXGT006273 Cytochrome b-245 heavy chain 1536 reviewed Ion channel
P05120 BXGT006319 Plasminogen activator inhibitor 2 5055 reviewed Enzyme modulator
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06280 BXGT006433 Alpha-galactosidase A 2717 reviewed
P06756 BXGT006499 Integrin alpha-V 3685 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10147 BXGT007543 C-C motif chemokine 3 6348 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10323 BXGT007557 Acrosin 49 reviewed Enzyme
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10809 BXGT007617 60 kDa heat shock protein, mitochondrial 3329 reviewed
P11308 BXGT007684 Transcriptional regulator ERG 2078 reviewed Transcription factor
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P12955 BXGT007865 Xaa-Pro dipeptidase 5184 reviewed Enzyme
P13236 BXGT007891 C-C motif chemokine 4 6351 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15090 BXGT008079 Fatty acid-binding protein, adipocyte 2167 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16070 BXGT008186 CD44 antigen 960 reviewed
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 1385 reviewed
P16671 BXGT008255 Platelet glycoprotein 4 948 reviewed Receptor
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19827 BXGT008523 Inter-alpha-trypsin inhibitor heavy chain H1 3697 reviewed Enzyme modulator
P19883 BXGT008528 Follistatin 10468 reviewed Enzyme modulator
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 1131 reviewed G-protein coupled receptor
P21359 BXGT008640 Neurofibromin 4763 reviewed Enzyme modulator
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P22083 BXGT008727 Alpha-(1,3)-fucosyltransferase 4 2526 reviewed Enzyme
P22894 BXGT008815 Neutrophil collagenase 4317 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24941 BXGT009002 Cyclin-dependent kinase 2 1017 reviewed Kinase
P25103 BXGT009020 Substance-P receptor 6869 reviewed G-protein coupled receptor
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P30411 BXGT009424 B2 bradykinin receptor 624 reviewed G-protein coupled receptor
P30536 BXGT009435 Translocator protein 706 reviewed
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P32119 BXGT009600 Peroxiredoxin-2 7001 reviewed Enzyme
P32418 BXGT009635 Sodium/calcium exchanger 1 6546 reviewed Transporter
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P34947 BXGT009774 G protein-coupled receptor kinase 5 2869 reviewed Kinase
P34972 BXGT009779 Cannabinoid receptor 2 1269 reviewed G-protein coupled receptor
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35408 BXGT009828 Prostaglandin E2 receptor EP4 subtype 5734 reviewed G-protein coupled receptor
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P36551 BXGT009927 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 1371 reviewed Enzyme
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P43026 BXGT010351 Growth/differentiation factor 5 8200 reviewed Signaling
P43235 BXGT010368 Cathepsin K 1513 reviewed Enzyme
P45452 BXGT010462 Collagenase 3 4322 reviewed Enzyme
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49585 BXGT010712 Choline-phosphate cytidylyltransferase A 5130 reviewed
P49747 BXGT010732 Cartilage oligomeric matrix protein 1311 reviewed
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P51884 BXGT010903 Lumican 4060 reviewed
P52564 BXGT010932 Dual specificity mitogen-activated protein kinase kinase 6 5608 reviewed Kinase
P53396 BXGT010988 ATP-citrate synthase 47 reviewed Enzyme
P54829 BXGT011085 Tyrosine-protein phosphatase non-receptor type 5 84867 reviewed
P55085 BXGT011104 Proteinase-activated receptor 2 2150 reviewed G-protein coupled receptor
P56945 BXGT011206 Breast cancer anti-estrogen resistance protein 1 9564 reviewed
P57059 BXGT011210 Serine/threonine-protein kinase SIK1 150094 reviewed
P57764 BXGT011217 Gasdermin-D 79792 reviewed
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P68104 BXGT011575 Elongation factor 1-alpha 1 1915 reviewed Enzyme
P78380 BXGT011841 Oxidized low-density lipoprotein receptor 1 4973 reviewed
P78556 BXGT011849 C-C motif chemokine 20 6364 reviewed Signaling
P80511 BXGT011914 Protein S100-A12 6283 reviewed Calcium-binding protein
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
P98066 BXGT012225 Tumor necrosis factor-inducible gene 6 protein 7130 reviewed
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
P98164 BXGT012230 Low-density lipoprotein receptor-related protein 2 4036 reviewed
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q12772 BXGT013262 Sterol regulatory element-binding protein 2 6721 reviewed
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q13336 BXGT013343 Urea transporter 1 6563 reviewed Transporter
Q13370 BXGT013345 cGMP-inhibited 3',5'-cyclic phosphodiesterase B 5140 reviewed
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q14011 BXGT013436 Cold-inducible RNA-binding protein 1153 reviewed Nucleic acid binding
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q15063 BXGT013531 Periostin 10631 reviewed Signaling
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16611 BXGT013644 Bcl-2 homologous antagonist/killer 578 reviewed Signaling
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16832 BXGT013678 Discoidin domain-containing receptor 2 4921 reviewed Kinase
Q16853 BXGT013683 Membrane primary amine oxidase 8639 reviewed
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q6UWM7 BXGT016566 Lactase-like protein 197021 reviewed Enzyme
Q6ZMJ4 BXGT016628 Interleukin-34 146433 reviewed
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 7442 reviewed Ion channel
Q8TEK3 BXGT018822 Histone-lysine N-methyltransferase, H3 lysine-79 specific 84444 reviewed Epigenetic regulator
Q8WUI4 BXGT018992 Histone deacetylase 7 51564 reviewed Epigenetic regulator
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q96PD4 BXGT019705 Interleukin-17F 112744 reviewed
Q99814 BXGT019965 Endothelial PAS domain-containing protein 1 2034 reviewed Transcription factor
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9BY66 BXGT020183 Lysine-specific demethylase 5D 8284 reviewed Transcription factor
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9C000 BXGT020206 NACHT, LRR and PYD domains-containing protein 1 22861 reviewed
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO 79068 reviewed
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9NYY3 BXGT021264 Serine/threonine-protein kinase PLK2 10769 reviewed Kinase
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 9451 reviewed Kinase
Q9UNA0 BXGT021784 A disintegrin and metalloproteinase with thrombospondin motifs 5 11096 reviewed Enzyme
Q9Y4K0 BXGT022280 Lysyl oxidase homolog 2 4017 reviewed
Q86US8 BXGT022850 Telomerase-binding protein EST1A 23293 reviewed
O14793 BXGT023280 Growth/differentiation factor 8 2660 reviewed Signaling
O00308 BXGT023349 NEDD4-like E3 ubiquitin-protein ligase WWP2 11060 reviewed Enzyme
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P46379 BXGT023748 Large proline-rich protein BAG6 7917 reviewed Enzyme modulator
Q5T2W1 BXGT023979 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 5174 reviewed
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
P62745 BXGT024248 Rho-related GTP-binding protein RhoB 388 reviewed Enzyme modulator
Q96A54 BXGT024681 Adiponectin receptor protein 1 51094 reviewed Receptor
P27918 BXGT025485 Properdin 5199 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease