Showing entry for Pleckstrin homology domain-containing family A member 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020513
Protein NamePleckstrin homology domain-containing family A member 1
Uniport IdQ9HB21
GenePLEKHA1
Gene Id59338
DomainPH
Pfam PF00169  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008209 androgen metabolic process
Biological Process GO:0050853 B cell receptor signaling pathway
Biological Process GO:0070301 cellular response to hydrogen peroxide
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0008210 estrogen metabolic process
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0033327 Leydig cell differentiation
Biological Process GO:0001553 luteinization
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0051898 negative regulation of protein kinase B signaling
Biological Process GO:0014065 phosphatidylinositol 3-kinase signaling
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0048008 platelet-derived growth factor receptor signaling pathway
Biological Process GO:0009791 post-embryonic development
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0031529 ruffle organization
Biological Process GO:0048705 skeletal system morphogenesis
Biological Process GO:0007283 spermatogenesis
molecular function GO:0030165 PDZ domain binding
molecular function GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0032587 ruffle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005890 BXGD000345 Body Height
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0271084 BXGD006159 Exudative age-related macular degeneration Eye Diseases
C0424678 BXGD008537 Lean body mass
C0871470 BXGD011316 Systolic Pressure
C3150797 BXGD018337 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
C4014795 BXGD020166 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
C4310768 BXGD022658 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein