Showing entry for Exudative age-related macular degeneration


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD006159
Disease NameExudative age-related macular degeneration
Disease CUI IdC0271084
MeSH Codes C11  
Disease Class NameEye Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00187 BXGT003890 Mannan-binding lectin serine protease 2 10747 reviewed Enzyme
O14786 BXGT004099 Neuropilin-1 8829 reviewed
O14965 BXGT004117 Aurora kinase A 6790 reviewed Kinase
O14994 BXGT004120 Synapsin-3 8224 reviewed Cellular structure
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15455 BXGT004171 Toll-like receptor 3 7098 reviewed Receptor
O43708 BXGT004617 Maleylacetoacetate isomerase 2954 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O94788 BXGT005333 Retinal dehydrogenase 2 8854 reviewed Enzyme
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O95477 BXGT005383 Phospholipid-transporting ATPase ABCA1 19 reviewed Transporter
O95907 BXGT005406 Monocarboxylate transporter 3 23539 reviewed Transporter
P00751 BXGT005643 Complement factor B 629 reviewed
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02511 BXGT005885 Alpha-crystallin B chain 1410 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02748 BXGT005940 Complement component C9 735 reviewed
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04275 BXGT006180 von Willebrand factor 7450 reviewed Enzyme modulator
P05155 BXGT006328 Plasma protease C1 inhibitor 710 reviewed Enzyme modulator
P05156 BXGT006329 Complement factor I 3426 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06681 BXGT006468 Complement C2 717 reviewed
P07333 BXGT006602 Macrophage colony-stimulating factor 1 receptor 1436 reviewed Kinase
P07355 BXGT006609 Annexin A2 302 reviewed
P08235 BXGT006751 Mineralocorticoid receptor 4306 reviewed Nuclear receptor
P08603 BXGT006798 Complement factor H 3075 reviewed
P08686 BXGT006813 Steroid 21-hydroxylase 1589 reviewed
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09237 BXGT006874 Matrilysin 4316 reviewed Enzyme
P09466 BXGT006892 Glycodelin 5047 reviewed Enzyme
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P11215 BXGT007672 Integrin alpha-M 3684 reviewed
P11597 BXGT007727 Cholesteryl ester transfer protein 1071 reviewed
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16671 BXGT008255 Platelet glycoprotein 4 948 reviewed Receptor
P17707 BXGT008331 S-adenosylmethionine decarboxylase proenzyme 262 reviewed Enzyme
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P22004 BXGT008718 Bone morphogenetic protein 6 654 reviewed Signaling
P22352 BXGT008758 Glutathione peroxidase 3 2878 reviewed Enzyme
P23945 BXGT008931 Follicle-stimulating hormone receptor 2492 reviewed G-protein coupled receptor
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P28161 BXGT009234 Glutathione S-transferase Mu 2 2946 reviewed
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P30988 BXGT009491 Calcitonin receptor 799 reviewed G-protein coupled receptor
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35398 BXGT009825 Nuclear receptor ROR-alpha 6095 reviewed Nuclear receptor
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P48029 BXGT010606 Sodium- and chloride-dependent creatine transporter 1 6535 reviewed Transporter
P49763 BXGT010737 Placenta growth factor 5228 reviewed Signaling
P49765 BXGT010738 Vascular endothelial growth factor B 7423 reviewed Signaling
P51993 BXGT010914 Alpha-(1,3)-fucosyltransferase 6 2528 reviewed Enzyme
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P78362 BXGT011839 SRSF protein kinase 2 6733 reviewed Kinase
P98155 BXGT012226 Very low-density lipoprotein receptor 7436 reviewed
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q07955 BXGT012951 Serine/arginine-rich splicing factor 1 6426 reviewed Nucleic acid binding
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q16874 BXGT013685 Cytochrome P450 21-hydroxylase 1589 unreviewed
Q6JQN1 BXGT016338 Acyl-CoA dehydrogenase family member 10 80724 reviewed Enzyme
Q92743 BXGT019368 Serine protease HTRA1 5654 reviewed Enzyme
Q92781 BXGT019372 Retinol dehydrogenase 5 5959 reviewed Enzyme
Q96L34 BXGT019689 MAP/microtubule affinity-regulating kinase 4 57787 reviewed Kinase
Q9GZT9 BXGT020425 Egl nine homolog 1 54583 reviewed
Q9HB21 BXGT020513 Pleckstrin homology domain-containing family A member 1 59338 reviewed Epigenetic regulator
Q9UKJ1 BXGT021744 Paired immunoglobulin-like type 2 receptor alpha 29992 reviewed
Q9ULV1 BXGT021764 Frizzled-4 8322 reviewed G-protein coupled receptor
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 10599 reviewed Transporter
Q5JP69 BXGT022691 C3/C5 convertase 717 unreviewed
Q01955 BXGT023255 Collagen alpha-3(IV) chain 1285 reviewed
P08123 BXGT024477 Collagen alpha-2(I) chain 1278 reviewed
Q9BY76 BXGT025687 Angiopoietin-related protein 4 51129 reviewed Signaling
Q5BJF2 BXGT026107 Sigma intracellular receptor 2 27346 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease