Showing entry for Nucleotide triphosphate diphosphatase NUDT15


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021222
Protein NameNucleotide triphosphate diphosphatase NUDT15
Uniport IdQ9NV35
GeneNUDT15
Gene Id55270
DomainNUDIX
Pfam PF00293  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006203 dGTP catabolic process
Biological Process GO:0042262 DNA protection
Biological Process GO:0042738 exogenous drug catabolic process
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0034656 nucleobase-containing small molecule catabolic process
Biological Process GO:1901292 nucleoside phosphate catabolic process
Biological Process GO:0006195 purine nucleotide catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0000302 response to reactive oxygen species
molecular function GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
molecular function GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
molecular function GO:0036218 dTTP diphosphatase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0035529 NADH pyrophosphatase activity
molecular function GO:0017110 nucleoside-diphosphatase activity
molecular function GO:0047429 nucleoside-triphosphate diphosphatase activity
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-15869 Metabolism of nucleotides
R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins
R-HSA-74259 Purine catabolism
R-HSA-8956319 Nucleobase catabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001824 BXGD000081 Agranulocytosis Hemic and Lymphatic Diseases
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0263504 BXGD005317 Alopecia totalis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Endocrine System Diseases
C0280962 BXGD006768 Bone Marrow Suppression Hemic and Lymphatic Diseases
C0333983 BXGD006975 Hyperplastic Polyp Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0342801 BXGD007558 Thiopurine S methyltranferase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Chemically-Induced Disorders
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0746883 BXGD010153 Febrile Neutropenia Hemic and Lymphatic Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4225160 BXGD022163 NUDT15 deficiency
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein