adisease

Showing entry for Neutropenia

General Disease Information
BXGD Id	BXGD002061
Disease Name	Neutropenia
Disease CUI Id	C0027947
MeSH Codes	C15
Disease Class Name	Hemic and Lymphatic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00337	BXGT003911	Sodium/nucleoside cotransporter 1	9154	reviewed	Transporter
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15245	BXGT004141	Solute carrier family 22 member 1	6580	reviewed	Transporter
O15439	BXGT004169	Multidrug resistance-associated protein 4	10257	reviewed	Transporter
O15440	BXGT004170	Multidrug resistance-associated protein 5	10057	reviewed	Transporter
O43464	BXGT004595	Serine protease HTRA2, mitochondrial	27429	reviewed
O43826	BXGT004629	Glucose-6-phosphate exchanger SLC37A4	2542	reviewed	Transporter
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60656	BXGT004889	UDP-glucuronosyltransferase 1-9	54600	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60858	BXGT004903	E3 ubiquitin-protein ligase TRIM13	10206	reviewed
O75015	BXGT005095	Low affinity immunoglobulin gamma Fc region receptor III-B	2215	reviewed	Cell adhesion
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O75914	BXGT005165	Serine/threonine-protein kinase PAK 3	5063	reviewed	Kinase
O95057	BXGT005346	GTP-binding protein Di-Ras1	148252	reviewed	Enzyme modulator
O95255	BXGT005363	Multidrug resistance-associated protein 6	368	reviewed	Transporter
O95551	BXGT005384	Tyrosyl-DNA phosphodiesterase 2	51567	reviewed
P00374	BXGT005520	Dihydrofolate reductase	1719	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01031	BXGT005720	Complement C5	727	reviewed	Enzyme modulator
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04155	BXGT006155	Trefoil factor 1	7031	reviewed	Signaling
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04732	BXGT006252	Metallothionein-1E	4493	reviewed
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05156	BXGT006329	Complement factor I	3426	reviewed
P05165	BXGT006334	Propionyl-CoA carboxylase alpha chain, mitochondrial	5095	reviewed	Enzyme
P05166	BXGT006335	Propionyl-CoA carboxylase beta chain, mitochondrial	5096	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06276	BXGT006430	Cholinesterase	590	reviewed
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P08708	BXGT006817	40S ribosomal protein S17	6218	reviewed	Nucleic acid binding
P08887	BXGT006835	Interleukin-6 receptor subunit alpha	3570	reviewed	Signaling
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10632	BXGT007592	Cytochrome P450 2C8	1558	reviewed
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P11172	BXGT007665	Uridine 5'-monophosphate synthase	7372	reviewed
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11387	BXGT007696	DNA topoisomerase 1	7150	reviewed	Enzyme
P11509	BXGT007716	Cytochrome P450 2A6	1548	reviewed
P11712	BXGT007738	Cytochrome P450 2C9	1559	reviewed
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P11912	BXGT007758	B-cell antigen receptor complex-associated protein alpha chain	973	reviewed	Receptor
P12268	BXGT007783	Inosine-5'-monophosphate dehydrogenase 2	3615	reviewed	Enzyme
P12314	BXGT007798	High affinity immunoglobulin gamma Fc receptor I	2209	reviewed	Cell adhesion
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15086	BXGT008078	Carboxypeptidase B	1360	reviewed	Enzyme
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P15814	BXGT008159	Immunoglobulin lambda-like polypeptide 1	3543	reviewed
P16109	BXGT008194	P-selectin	6403	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P16581	BXGT008245	E-selectin	6401	reviewed
P16871	BXGT008269	Interleukin-7 receptor subunit alpha	3575	reviewed	Receptor
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19224	BXGT008468	UDP-glucuronosyltransferase 1-6	54578	reviewed
P19801	BXGT008516	Amiloride-sensitive amine oxidase [copper-containing]	26	reviewed
P20062	BXGT008543	Transcobalamin-2	6948	reviewed
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P20815	BXGT008604	Cytochrome P450 3A5	1577	reviewed	Enzyme
P20933	BXGT008618	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	175	reviewed	Enzyme
P21730	BXGT008687	C5a anaphylatoxin chemotactic receptor 1	728	reviewed	G-protein coupled receptor
P22033	BXGT008721	Methylmalonyl-CoA mutase, mitochondrial	4594	reviewed	Enzyme
P22309	BXGT008753	UDP-glucuronosyltransferase 1-1	54658	reviewed
P22310	BXGT008754	UDP-glucuronosyltransferase 1-4	54657	reviewed
P23141	BXGT008830	Liver carboxylesterase 1	1066	reviewed	Enzyme
P23458	BXGT008868	Tyrosine-protein kinase JAK1	3716	reviewed	Kinase
P23921	BXGT008927	Ribonucleoside-diphosphate reductase large subunit	6240	reviewed	Enzyme
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P25105	BXGT009021	Platelet-activating factor receptor	5724	reviewed	G-protein coupled receptor
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	5295	reviewed	Kinase
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31513	BXGT009546	Dimethylaniline monooxygenase [N-oxide-forming] 3	2328	reviewed	Enzyme
P32320	BXGT009622	Cytidine deaminase	978	reviewed	Enzyme
P32321	BXGT009623	Deoxycytidylate deaminase	1635	reviewed	Enzyme
P33261	BXGT009707	Cytochrome P450 2C19	1557	reviewed
P33527	BXGT009728	Multidrug resistance-associated protein 1	4363	reviewed	Transporter
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P35503	BXGT009840	UDP-glucuronosyltransferase 1-3	54659	reviewed
P36888	BXGT009938	Receptor-type tyrosine-protein kinase FLT3	2322	reviewed	Kinase
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P40225	BXGT010168	Thrombopoietin	7066	reviewed
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43489	BXGT010394	Tumor necrosis factor receptor superfamily member 4	7293	reviewed
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48637	BXGT010649	Glutathione synthetase	2937	reviewed	Enzyme
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49023	BXGT010672	Paxillin	5829	reviewed	Cellular structure
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51159	BXGT010839	Ras-related protein Rab-27A	5873	reviewed
P51580	BXGT010864	Thiopurine S-methyltransferase	7172	reviewed
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P53350	BXGT010984	Serine/threonine-protein kinase PLK1	5347	reviewed	Kinase
P53355	BXGT010985	Death-associated protein kinase 1	1612	reviewed	Kinase
P54707	BXGT011068	Potassium-transporting ATPase alpha chain 2	479	reviewed	Transporter
P55040	BXGT011099	GTP-binding protein GEM	2669	reviewed
P55263	BXGT011115	Adenosine kinase	132	reviewed	Kinase
P56537	BXGT011177	Eukaryotic translation initiation factor 6	3692	reviewed	Nucleic acid binding
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60953	BXGT011342	Cell division control protein 42 homolog	998	reviewed	Enzyme modulator
P61011	BXGT011346	Signal recognition particle 54 kDa protein	6729	reviewed	Nucleic acid binding
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P78310	BXGT011830	Coxsackievirus and adenovirus receptor	1525	reviewed
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q01650	BXGT012603	Large neutral amino acids transporter small subunit 1	8140	reviewed	Transporter
Q01831	BXGT012621	DNA repair protein complementing XP-C cells	7508	reviewed	Nucleic acid binding
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q05397	BXGT012815	Focal adhesion kinase 1	5747	reviewed	Kinase
Q05516	BXGT012822	Zinc finger and BTB domain-containing protein 16	7704	reviewed	Transcription factor
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q06830	BXGT012894	Peroxiredoxin-1	5052	reviewed	Enzyme
Q07020	BXGT012914	60S ribosomal protein L18	6141	reviewed	Nucleic acid binding
Q07343	BXGT012926	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	5142	reviewed
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q12866	BXGT013273	Tyrosine-protein kinase Mer	10461	reviewed	Kinase
Q12882	BXGT013276	Dihydropyrimidine dehydrogenase [NADP(+)]	1806	reviewed	Enzyme
Q13043	BXGT013307	Serine/threonine-protein kinase 4	6789	reviewed	Kinase
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q14994	BXGT013519	Nuclear receptor subfamily 1 group I member 3	9970	reviewed	Nuclear receptor
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15717	BXGT013589	ELAV-like protein 1	1994	reviewed
Q16637	BXGT013646	Survival motor neuron protein	6607	reviewed	Epigenetic regulator
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q5T3U5	BXGT015846	Multidrug resistance-associated protein 7	89845	reviewed	Transporter
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q86TM3	BXGT017607	Probable ATP-dependent RNA helicase DDX53	168400	reviewed
Q8NEM0	BXGT018555	Microcephalin	79648	reviewed	Nucleic acid binding
Q92794	BXGT019375	Histone acetyltransferase KAT6A	7994	reviewed	Enzyme
Q92887	BXGT019389	Canalicular multispecific organic anion transporter 1	1244	reviewed	Transporter
Q96EY8	BXGT019655	Corrinoid adenosyltransferase	326625	reviewed	Enzyme
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q99808	BXGT019964	Equilibrative nucleoside transporter 1	2030	reviewed	Transporter
Q9BQ65	BXGT020107	U6 snRNA phosphodiesterase	79650	reviewed
Q9BY32	BXGT020179	Inosine triphosphate pyrophosphatase	3704	reviewed	Enzyme
Q9HAS3	BXGT020507	Solute carrier family 28 member 3	64078	reviewed	Transporter
Q9HAW7	BXGT020508	UDP-glucuronosyltransferase 1-7	54577	reviewed
Q9HAW8	BXGT020509	UDP-glucuronosyltransferase 1-10	54575	reviewed
Q9HAW9	BXGT020510	UDP-glucuronosyltransferase 1-8	54576	reviewed
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NPD5	BXGT021151	Solute carrier organic anion transporter family member 1B3	28234	reviewed	Transporter
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	55775	reviewed	Enzyme
Q9NV35	BXGT021222	Nucleotide triphosphate diphosphatase NUDT15	55270	reviewed
Q9NWZ3	BXGT021239	Interleukin-1 receptor-associated kinase 4	51135	reviewed	Kinase
Q9NZJ5	BXGT021275	Eukaryotic translation initiation factor 2-alpha kinase 3	9451	reviewed	Kinase
Q9P2W7	BXGT021306	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	27087	reviewed	Enzyme
Q9UBZ9	BXGT021666	DNA repair protein REV1	51455	reviewed
Q9UH03	BXGT021690	Neuronal-specific septin-3	55964	reviewed	Enzyme modulator
Q9UI95	BXGT021714	Mitotic spindle assembly checkpoint protein MAD2B	10459	reviewed
Q9UJU2	BXGT021730	Lymphoid enhancer-binding factor 1	51176	reviewed
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9Y4U1	BXGT022285	Methylmalonic aciduria and homocystinuria type C protein	25974	reviewed
Q9Y6K9	BXGT022333	NF-kappa-B essential modulator	8517	reviewed	Kinase
Q9Y6L6	BXGT022334	Solute carrier organic anion transporter family member 1B1	10599	reviewed	Transporter
P19875	BXGT023294	C-X-C motif chemokine 2	2920	reviewed	Signaling
P31994	BXGT023298	Low affinity immunoglobulin gamma Fc region receptor II-b	2213	reviewed	Cell adhesion
P07954	BXGT023939	Fumarate hydratase, mitochondrial	2271	reviewed	Enzyme
Q9Y294	BXGT023981	Histone chaperone ASF1A	25842	reviewed	Nucleic acid binding
Q9UKP6	BXGT024239	Urotensin-2 receptor	2837	reviewed	G-protein coupled receptor
P29590	BXGT024350	Protein PML	5371	reviewed
P20809	BXGT025043	Interleukin-11	3589	reviewed
Q14980	BXGT025336	Nuclear mitotic apparatus protein 1	4926	reviewed
P28715	BXGT025675	DNA repair protein complementing XP-G cells	2073	reviewed
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
P11836	BXGT025994	B-lymphocyte antigen CD20	931	reviewed	Receptor
P62263	BXGT026033	40S ribosomal protein S14	6208	reviewed	Nucleic acid binding

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}