Showing entry for Potassium channel subfamily K member 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021257
Protein NamePotassium channel subfamily K member 4
Uniport IdQ9NYG8
GeneKCNK4
Gene Id50801
DomainIon_trans_2
Pfam PF07885  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071469 cellular response to alkaline pH
Biological Process GO:0071398 cellular response to fatty acid
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0071502 cellular response to temperature stimulus
Biological Process GO:0050976 detection of mechanical stimulus involved in sensory perception of touch
Biological Process GO:0007613 memory
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0006813 potassium ion transport
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0050951 sensory perception of temperature stimulus
Biological Process GO:0030322 stabilization of membrane potential
molecular function GO:0042802 identical protein binding
molecular function GO:0098782 mechanosensitived potassium channel activity
molecular function GO:0005267 potassium channel activity
molecular function GO:0022841 potassium ion leak channel activity
molecular function GO:0097604 temperature-gated cation channel activity
molecular function GO:0005244 voltage-gated ion channel activity
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0034705 potassium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296071 Potassium Channels
R-HSA-1296346 Tandem pore domain potassium channels
R-HSA-1299503 TWIK related potassium channel (TREK)
R-HSA-397014 Muscle contraction
R-HSA-5576886 Phase 4 - resting membrane potential
R-HSA-5576891 Cardiac conduction
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003466 BXGD000193 Anus, Imperforate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0015826 BXGD001022 Fenestration (morphologic abnormality)
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0020555 BXGD001431 Hypertrichosis Skin and Connective Tissue Diseases
C0024433 BXGD001771 Macrostomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0239234 BXGD004974 Low set ears
C0266617 BXGD005700 Congenital anomaly of face Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0376480 BXGD007998 Gingival Overgrowth Stomatognathic Diseases
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0431447 BXGD008690 Synophrys Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0796013 BXGD010778 Zimmerman Laband syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1142533 BXGD011758 Smooth philtrum
C1839758 BXGD014402 Narrow forehead
C1839797 BXGD014409 Deep philtrum
C1843367 BXGD014576 Poor school performance
C1845251 BXGD014734 Facial hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853487 BXGD015340 Thick eyebrow
C1853738 BXGD015357 Long eyelashes
C1854301 BXGD015391 Motor delay Mental Disorders
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861324 BXGD016029 Short philtrum
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C3277019 BXGD018698 Horizontal eyebrow
C3277940 BXGD018725 Generalized hypertrichosis Skin and Connective Tissue Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4022738 BXGD020974 Neurodevelopmental delay
C4023698 BXGD021247 Everted upper lip vermilion
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002591 Potassium 39.1
BXGC0003500 N-Decane 142.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein