Showing entry for Retinol dehydrogenase 8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021261
Protein NameRetinol dehydrogenase 8
Uniport IdQ9NYR8
GeneRDH8
Gene Id50700
Domainadh_short
Pfam PF00106  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006703 estrogen biosynthetic process
Biological Process GO:0050896 response to stimulus
Biological Process GO:0006694 steroid biosynthetic process
Biological Process GO:0007601 visual perception
molecular function GO:0004303 estradiol 17-beta-dehydrogenase activity
molecular function GO:0052650 NADP-retinol dehydrogenase activity
molecular function GO:0004745 retinol dehydrogenase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005887 integral component of plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-2187338 Visual phototransduction
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0027092 BXGD001971 Myopia Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0271093 BXGD006162 Stargardt's disease
C0271183 BXGD006169 Severe myopia Eye Diseases
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047568 Retinol 286.23
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein