Showing entry for SUMO-activating enzyme subunit 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021651
Protein NameSUMO-activating enzyme subunit 1
Uniport IdQ9UBE0
GeneSAE1
Gene Id10055
DomainThiF
Pfam PF00899  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0033235 positive regulation of protein sumoylation
Biological Process GO:1903955 positive regulation of protein targeting to mitochondrion
Biological Process GO:0032446 protein modification by small protein conjugation
Biological Process GO:0016925 protein sumoylation
molecular function GO:0043008 ATP-dependent protein binding
molecular function GO:0008047 enzyme activator activity
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0044388 small protein activating enzyme binding
molecular function GO:0004839 ubiquitin activating enzyme activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0031510 SUMO activating enzyme complex
Reactome
Pathway Id Pathway Name
R-HSA-2990846 SUMOylation
R-HSA-2990846 SUMOylation
R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-HSA-3215018 Processing and activation of SUMO
R-HSA-3215018 Processing and activation of SUMO
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0023508 BXGD001675 White Blood Cell Count procedure
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0158646 BXGD003897 Cleft palate with cleft lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200635 BXGD004041 Lymphocyte Count measurement
C0202236 BXGD004086 Triglycerides measurement
C0751356 BXGD010406 Idiopathic Inflammatory Myopathies Musculoskeletal Diseases; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000523 2-Hydroxy-6-pentadecylbenzoic acid 348.52
BXGC0002971 alpha-Lipoic acid 206.33
BXGC0023292 Gingkolic Acid 346.25
BXGC0026607 epiberberine 336.12
BXGC0035226 Betulinic Acid 456.36
BXGC0040358 Lobaric Acid 456.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein