Showing entry for Exostosin-like 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021660
Protein NameExostosin-like 2
Uniport IdQ9UBQ6
GeneEXTL2
Gene Id2135
DomainGlyco_transf_64
Pfam PF09258  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015012 heparan sulfate proteoglycan biosynthetic process
Biological Process GO:0036498 IRE1-mediated unfolded protein response
Biological Process GO:0006044 N-acetylglucosamine metabolic process
Biological Process GO:0006486 protein glycosylation
Biological Process GO:0019276 UDP-N-acetylgalactosamine metabolic process
molecular function GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity
molecular function GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
molecular function GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
molecular function GO:0005539 glycosaminoglycan binding
molecular function GO:0030145 manganese ion binding
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005576 extracellular region
cellular component GO:0016021 integral component of membrane
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0015306 BXGD000975 Hereditary Multiple Exostoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases
C0026703 BXGD001919 Mucopolysaccharidoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029454 BXGD002155 Osteopetrosis Musculoskeletal Diseases
C0086647 BXGD003298 Mucopolysaccharidosis Type IIIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0086649 BXGD003300 MPS III C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003993 Uridine diphosphate 404.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein