Showing entry for STE20/SPS1-related proline-alanine-rich protein kinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021675
Protein NameSTE20/SPS1-related proline-alanine-rich protein kinase
Uniport IdQ9UEW8
GeneSTK39
Gene Id27347
DomainOSR1_C; Pkinase
Pfam PF12202   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0071476 cellular hypotonic response
Biological Process GO:1990869 cellular response to chemokine
Biological Process GO:0038146 chemokine (C-X-C motif) ligand 12 signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0050801 ion homeostasis
Biological Process GO:0036438 maintenance of lens transparency
Biological Process GO:1905408 negative regulation of creatine transmembrane transporter activity
Biological Process GO:0090188 negative regulation of pancreatic juice secretion
Biological Process GO:1901380 negative regulation of potassium ion transmembrane transport
Biological Process GO:1901017 negative regulation of potassium ion transmembrane transporter activity
Biological Process GO:2000650 negative regulation of sodium ion transmembrane transporter activity
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0032414 positive regulation of ion transmembrane transporter activity
Biological Process GO:0043268 positive regulation of potassium ion transport
Biological Process GO:0010820 positive regulation of T cell chemotaxis
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0023014 signal transduction by protein phosphorylation
Biological Process GO:0023016 signal transduction by trans-phosphorylation
molecular function GO:0005524 ATP binding
molecular function GO:0016301 kinase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0019898 extrinsic component of membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005823 BXGD000339 Blood Pressure
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0268450 BXGD005951 Gitelman Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0339539 BXGD007265 Familial Exudative Vitreoretinopathy
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740392 BXGD009988 Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1449844 BXGD013095 Pseudohypoaldosteronism, Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4288936 BXGD022490 Hyperkalemic Mineralocorticoid Resistance
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein