Showing entry for Sporadic Parkinson disease


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD023002
Disease NameSporadic Parkinson disease
Disease CUI IdC4511452
MeSH Codes C10  
Disease Class NameNervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00429 BXGT003919 Dynamin-1-like protein 10059 reviewed Enzyme modulator
O14994 BXGT004120 Synapsin-3 8224 reviewed Cellular structure
O43464 BXGT004595 Serine protease HTRA2, mitochondrial 27429 reviewed
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75509 BXGT005133 Tumor necrosis factor receptor superfamily member 21 27242 reviewed
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P01011 BXGT005715 Alpha-1-antichymotrypsin 12 reviewed Enzyme modulator
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01903 BXGT005814 HLA class II histocompatibility antigen, DR alpha chain 3122 reviewed Immune response
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P04062 BXGT006140 Lysosomal acid glucosylceramidase 2629 reviewed
P04083 BXGT006147 Annexin A1 301 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase 2597 reviewed Enzyme
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05937 BXGT006396 Calbindin 793 reviewed Calcium-binding protein
P06280 BXGT006433 Alpha-galactosidase A 2717 reviewed
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07203 BXGT006566 Glutathione peroxidase 1 2876 reviewed Enzyme
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09936 BXGT006943 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7345 reviewed Enzyme
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P15559 BXGT008139 NAD(P)H dehydrogenase [quinone] 1 1728 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P17405 BXGT008304 Sphingomyelin phosphodiesterase 6609 reviewed Enzyme
P20810 BXGT008602 Calpastatin 831 reviewed
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P21728 BXGT008686 D(1A) dopamine receptor 1812 reviewed G-protein coupled receptor
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22352 BXGT008758 Glutathione peroxidase 3 2878 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P27338 BXGT009172 Amine oxidase [flavin-containing] B 4129 reviewed
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35270 BXGT009807 Sepiapterin reductase 6697 reviewed
P35462 BXGT009835 D(3) dopamine receptor 1814 reviewed G-protein coupled receptor
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36639 BXGT009930 7,8-dihydro-8-oxoguanine triphosphatase 4521 reviewed Enzyme
P36956 BXGT009947 Sterol regulatory element-binding protein 1 6720 reviewed
P36969 BXGT009949 Phospholipid hydroperoxide glutathione peroxidase 2879 reviewed Enzyme
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P45985 BXGT010496 Dual specificity mitogen-activated protein kinase kinase 4 6416 reviewed Kinase
P48730 BXGT010656 Casein kinase I isoform delta 1453 reviewed Kinase
P51531 BXGT010851 Probable global transcription activator SNF2L2 6595 reviewed Epigenetic regulator
P54098 BXGT011030 DNA polymerase subunit gamma-1 5428 reviewed Enzyme
P61026 BXGT011351 Ras-related protein Rab-10 10890 reviewed
P61086 BXGT011357 Ubiquitin-conjugating enzyme E2 K 3093 reviewed
P78368 BXGT011840 Casein kinase I isoform gamma-2 1455 reviewed Kinase
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q01453 BXGT012588 Peripheral myelin protein 22 5376 reviewed Cellular structure
Q01726 BXGT012610 Melanocyte-stimulating hormone receptor 4157 reviewed G-protein coupled receptor
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q04637 BXGT012771 Eukaryotic translation initiation factor 4 gamma 1 1981 reviewed Nucleic acid binding
Q10588 BXGT013202 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 683 reviewed Enzyme
Q13427 BXGT013354 Peptidyl-prolyl cis-trans isomerase G 9360 reviewed
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q14108 BXGT013440 Lysosome membrane protein 2 950 reviewed Receptor
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16678 BXGT013656 Cytochrome P450 1B1 1545 reviewed Enzyme
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q676U5 BXGT016177 Autophagy-related protein 16-1 55054 reviewed
Q8IXI2 BXGT018361 Mitochondrial Rho GTPase 1 55288 reviewed Enzyme modulator
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 22933 reviewed Epigenetic regulator
Q8TDX5 BXGT018816 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase 130013 reviewed
Q8TF61 BXGT018824 F-box only protein 41 150726 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96FE5 BXGT019657 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 84894 reviewed Receptor
Q96QK1 BXGT019720 Vacuolar protein sorting-associated protein 35 55737 reviewed Transporter
Q96RQ3 BXGT019732 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial 56922 reviewed Enzyme
Q99572 BXGT019935 P2X purinoceptor 7 5027 reviewed Ion channel
Q9BXM7 BXGT020172 Serine/threonine-protein kinase PINK1, mitochondrial 65018 reviewed Kinase
Q9HC29 BXGT020526 Nucleotide-binding oligomerization domain-containing protein 2 64127 reviewed Enzyme
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B 1789 reviewed
Q9UEW8 BXGT021675 STE20/SPS1-related proline-alanine-rich protein kinase 27347 reviewed Kinase
Q9Y233 BXGT022210 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 10846 reviewed
Q9Y3I1 BXGT022260 F-box only protein 7 25793 reviewed
Q9Y6M4 BXGT022335 Casein kinase I isoform gamma-3 1456 reviewed Kinase
Q13029 BXGT022688 PR domain zinc finger protein 2 7799 reviewed
P56703 BXGT023722 Proto-oncogene Wnt-3 7473 reviewed Signaling
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease