Showing entry for Group IID secretory phospholipase A2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021789
Protein NameGroup IID secretory phospholipase A2
Uniport IdQ9UNK4
GenePLA2G2D
Gene Id26279
DomainPhospholip_A2_1
Pfam PF00068  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00564 Glycerophospholipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00565 Ether lipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00591 Linoleic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00592 alpha-Linolenic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04975 Fat digestion and absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0050482 arachidonic acid secretion
Biological Process GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Biological Process GO:0006954 inflammatory response
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0042130 negative regulation of T cell proliferation
Biological Process GO:0006654 phosphatidic acid biosynthetic process
Biological Process GO:0036151 phosphatidylcholine acyl-chain remodeling
Biological Process GO:0046470 phosphatidylcholine metabolic process
Biological Process GO:0036152 phosphatidylethanolamine acyl-chain remodeling
Biological Process GO:0046337 phosphatidylethanolamine metabolic process
Biological Process GO:0036148 phosphatidylglycerol acyl-chain remodeling
Biological Process GO:0036149 phosphatidylinositol acyl-chain remodeling
Biological Process GO:0036150 phosphatidylserine acyl-chain remodeling
Biological Process GO:0006644 phospholipid metabolic process
Biological Process GO:0002864 regulation of acute inflammatory response to antigenic stimulus
molecular function GO:0047498 calcium-dependent phospholipase A2 activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0043395 heparan sulfate proteoglycan binding
molecular function GO:0008201 heparin binding
molecular function GO:0004623 phospholipase A2 activity
molecular function GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
molecular function GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
molecular function GO:0005543 phospholipid binding
cellular component GO:0005576 extracellular region
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001486 BXGD000056 Adenovirus Infections Infections
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0008311 BXGD000526 Cholangitis Digestive System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024894 BXGD001810 Mastitis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0239211 BXGD004972 Oedema auricular Pathological Conditions, Signs and Symptoms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002187 Octadecanoic acid 284.48
BXGC0002248 Dodecanoic acid 200.32
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein