adisease

Showing entry for Craniosynostosis

General Disease Information
BXGD Id	BXGD000660
Disease Name	Craniosynostosis
Disease CUI Id	C0010278
MeSH Codes	C16 C05
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000152 HP:0000924
Human Phenotype Ontology Term	Abnormality of head or neck; Abnormality of the skeletal system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00444	BXGT003921	Serine/threonine-protein kinase PLK4	10733	reviewed	Kinase
O00522	BXGT003935	Krev interaction trapped protein 1	889	reviewed
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O15496	BXGT004175	Group 10 secretory phospholipase A2	8399	reviewed	Enzyme
O43318	BXGT004586	Mitogen-activated protein kinase kinase kinase 7	6885	reviewed	Kinase
O43929	BXGT004638	Origin recognition complex subunit 4	5000	reviewed	Nucleic acid binding
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O60858	BXGT004903	E3 ubiquitin-protein ligase TRIM13	10206	reviewed
O75369	BXGT005119	Filamin-B	2317	reviewed
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O75496	BXGT005132	Geminin	51053	reviewed
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	8989	reviewed	Ion channel
O94766	BXGT005330	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	26229	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00750	BXGT005642	Tissue-type plasminogen activator	5327	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01732	BXGT005782	T-cell surface glycoprotein CD8 alpha chain	925	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02788	BXGT005963	Lactotransferrin	4057	reviewed	Enzyme
P02818	BXGT005969	Osteocalcin	632	reviewed
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04054	BXGT006136	Phospholipase A2	5319	reviewed	Enzyme
P04155	BXGT006155	Trefoil factor 1	7031	reviewed	Signaling
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05186	BXGT006338	Alkaline phosphatase, tissue-nonspecific isozyme	249	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P07332	BXGT006601	Tyrosine-protein kinase Fes/Fps	2242	reviewed	Kinase
P08034	BXGT006716	Gap junction beta-1 protein	2705	reviewed	Cell-cell junction
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08133	BXGT006727	Annexin A6	309	reviewed
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08620	BXGT006800	Fibroblast growth factor 4	2249	reviewed	Signaling
P08637	BXGT006802	Low affinity immunoglobulin gamma Fc region receptor III-A	2214	reviewed	Cell adhesion
P08670	BXGT006810	Vimentin	7431	reviewed
P08887	BXGT006835	Interleukin-6 receptor subunit alpha	3570	reviewed	Signaling
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P0DP23	BXGT007520	Calmodulin-1	808	reviewed
P0DP24	BXGT007521	Calmodulin-2	808	reviewed
P10144	BXGT007541	Granzyme B	3002	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12724	BXGT007837	Eosinophil cationic protein	6037	reviewed
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P13727	BXGT007951	Bone marrow proteoglycan	5553	reviewed	Enzyme modulator
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14555	BXGT008020	Phospholipase A2, membrane associated	5320	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P15538	BXGT008137	Cytochrome P450 11B1, mitochondrial	1584	reviewed
P16050	BXGT008184	Arachidonate 15-lipoxygenase	246	reviewed	Enzyme
P16157	BXGT008203	Ankyrin-1	286	reviewed
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16435	BXGT008226	NADPH--cytochrome P450 reductase	5447	reviewed
P17844	BXGT008346	Probable ATP-dependent RNA helicase DDX5	1655	reviewed
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18827	BXGT008427	Syndecan-1	6382	reviewed	Extracellular structure
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P19429	BXGT008479	Troponin I, cardiac muscle	7137	reviewed	Cellular structure
P20292	BXGT008561	Arachidonate 5-lipoxygenase-activating protein	241	reviewed	Enzyme
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21333	BXGT008638	Filamin-A	2316	reviewed
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P21709	BXGT008685	Ephrin type-A receptor 1	2041	reviewed	Kinase
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P22455	BXGT008772	Fibroblast growth factor receptor 4	2264	reviewed	Kinase
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P23458	BXGT008868	Tyrosine-protein kinase JAK1	3716	reviewed	Kinase
P23528	BXGT008879	Cofilin-1	1072	reviewed
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P25311	BXGT009036	Zinc-alpha-2-glycoprotein	563	reviewed
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P27708	BXGT009202	CAD protein	790	reviewed	Enzyme
P28039	BXGT009224	Acyloxyacyl hydrolase	313	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28845	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	3290	reviewed
P29033	BXGT009308	Gap junction beta-2 protein	2706	reviewed	Cell-cell junction
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P30533	BXGT009434	Alpha-2-macroglobulin receptor-associated protein	4043	reviewed
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31151	BXGT009510	Protein S100-A7	6278	reviewed	Calcium-binding protein
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32004	BXGT009594	Neural cell adhesion molecule L1	3897	reviewed
P32926	BXGT009680	Desmoglein-3	1830	reviewed	Cell adhesion
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P34947	BXGT009774	G protein-coupled receptor kinase 5	2869	reviewed	Kinase
P35052	BXGT009788	Glypican-1	2817	reviewed
P35247	BXGT009804	Pulmonary surfactant-associated protein D	6441	reviewed	Surfactant
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35408	BXGT009828	Prostaglandin E2 receptor EP4 subtype	5734	reviewed	G-protein coupled receptor
P35499	BXGT009839	Sodium channel protein type 4 subunit alpha	6329	reviewed	Ion channel
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36222	BXGT009914	Chitinase-3-like protein 1	1116	reviewed
P36894	BXGT009939	Bone morphogenetic protein receptor type-1A	657	reviewed	Kinase
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P40189	BXGT010164	Interleukin-6 receptor subunit beta	3572	reviewed	Signaling
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P48740	BXGT010659	Mannan-binding lectin serine protease 1	5648	reviewed	Enzyme
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P53370	BXGT010987	Nucleoside diphosphate-linked moiety X motif 6	11162	reviewed	Enzyme
P54707	BXGT011068	Potassium-transporting ATPase alpha chain 2	479	reviewed	Transporter
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P55774	BXGT011124	C-C motif chemokine 18	6362	reviewed	Signaling
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P61106	BXGT011360	Ras-related protein Rab-14	51552	reviewed
P61626	BXGT011382	Lysozyme C	4069	reviewed
P61978	BXGT011399	Heterogeneous nuclear ribonucleoprotein K	3190	reviewed	Enzyme
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P78310	BXGT011830	Coxsackievirus and adenovirus receptor	1525	reviewed
P78504	BXGT011844	Protein jagged-1	182	reviewed
P78540	BXGT011848	Arginase-2, mitochondrial	384	reviewed	Enzyme
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q02224	BXGT012643	Centromere-associated protein E	1062	reviewed	Cellular structure
Q03518	BXGT012723	Antigen peptide transporter 1	6890	reviewed	Transporter
Q03692	BXGT012735	Collagen alpha-1(X) chain	1300	reviewed	Extracellular structure
Q05315	BXGT012811	Galectin-10	1178	reviewed	Signaling
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06830	BXGT012894	Peroxiredoxin-1	5052	reviewed	Enzyme
Q07011	BXGT012912	Tumor necrosis factor receptor superfamily member 9	3604	reviewed
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07973	BXGT012952	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	1591	reviewed	Enzyme
Q08174	BXGT012963	Protocadherin-1	5097	reviewed
Q08209	BXGT012968	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	5530	reviewed
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q13415	BXGT013350	Origin recognition complex subunit 1	4998	reviewed	Nucleic acid binding
Q13526	BXGT013369	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5300	reviewed
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q14623	BXGT013490	Indian hedgehog protein	3549	reviewed
Q14683	BXGT013500	Structural maintenance of chromosomes protein 1A	8243	reviewed
Q14994	BXGT013519	Nuclear receptor subfamily 1 group I member 3	9970	reviewed	Nuclear receptor
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16568	BXGT013640	Cocaine- and amphetamine-regulated transcript protein	9607	reviewed
Q16637	BXGT013646	Survival motor neuron protein	6607	reviewed	Epigenetic regulator
Q16827	BXGT013675	Receptor-type tyrosine-protein phosphatase O	5800	reviewed
Q5S007	BXGT015650	Leucine-rich repeat serine/threonine-protein kinase 2	120892	reviewed	Kinase
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6NUK1	BXGT016429	Calcium-binding mitochondrial carrier protein SCaMC-1	29957	reviewed	Transporter
Q7L3T8	BXGT016994	Probable proline--tRNA ligase, mitochondrial	25973	reviewed	Enzyme
Q86UE8	BXGT017612	Serine/threonine-protein kinase tousled-like 2	11011	reviewed	Kinase
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q92794	BXGT019375	Histone acetyltransferase KAT6A	7994	reviewed	Enzyme
Q92876	BXGT019388	Kallikrein-6	5653	reviewed	Enzyme
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96IY4	BXGT019678	Carboxypeptidase B2	1361	reviewed	Enzyme
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99467	BXGT019923	CD180 antigen	4064	reviewed	Receptor
Q99835	BXGT019969	Smoothened homolog	6608	reviewed	G-protein coupled receptor
Q9BWP8	BXGT020153	Collectin-11	78989	reviewed	Surfactant
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NP55	BXGT021141	BPI fold-containing family A member 1	51297	reviewed
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NWZ3	BXGT021239	Interleukin-1 receptor-associated kinase 4	51135	reviewed	Kinase
Q9NYK1	BXGT021258	Toll-like receptor 7	51284	reviewed
Q9UKV8	BXGT021752	Protein argonaute-2	27161	reviewed
Q9UNK4	BXGT021789	Group IID secretory phospholipase A2	26279	reviewed	Enzyme
Q9Y271	BXGT022222	Cysteinyl leukotriene receptor 1	10800	reviewed	G-protein coupled receptor
Q9Y5X0	BXGT022305	Sorting nexin-10	29887	reviewed
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
Q7Z624	BXGT022792	Calmodulin-lysine N-methyltransferase	79823	reviewed
Q9UK05	BXGT023094	Growth/differentiation factor 2	2658	reviewed	Signaling
Q9GZQ8	BXGT023414	Microtubule-associated proteins 1A/1B light chain 3B	81631	reviewed	Cellular structure
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
P0DP25	BXGT024595	Calmodulin-3	808	reviewed
Q96L73	BXGT024676	Histone-lysine N-methyltransferase, H3 lysine-36 specific	64324	reviewed	Epigenetic regulator
P20809	BXGT025043	Interleukin-11	3589	reviewed
P31358	BXGT025061	CAMPATH-1 antigen	1043	reviewed
Q92832	BXGT025242	Protein kinase C-binding protein NELL1	4745	reviewed	Calcium-binding protein
Q9UGM3	BXGT025543	Deleted in malignant brain tumors 1 protein	1755	reviewed	Enzyme
Q969H8	BXGT025606	Myeloid-derived growth factor	56005	reviewed
P51798	BXGT026083	H(+)/Cl(-) exchange transporter 7	1186	reviewed	Ion channel
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}