Showing entry for Protein mono-ADP-ribosyltransferase PARP3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022328
Protein NameProtein mono-ADP-ribosyltransferase PARP3
Uniport IdQ9Y6F1
GenePARP3
Gene Id10039
DomainPARP; PARP_reg; WGR
Pfam PF00644   PF02877   PF05406  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03410 Base excision repair
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030592 DNA ADP-ribosylation
Biological Process GO:0006281 DNA repair
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0045829 negative regulation of isotype switching
Biological Process GO:1905662 negative regulation of telomerase RNA reverse transcriptase activity
Biological Process GO:0051106 positive regulation of DNA ligation
Biological Process GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
Biological Process GO:0006471 protein ADP-ribosylation
Biological Process GO:0070213 protein auto-ADP-ribosylation
Biological Process GO:1990166 protein localization to site of double-strand break
Biological Process GO:0140289 protein mono-ADP-ribosylation
Biological Process GO:0070212 protein poly-ADP-ribosylation
Biological Process GO:0060236 regulation of mitotic spindle organization
Biological Process GO:0000723 telomere maintenance
molecular function GO:0003824 catalytic activity
molecular function GO:0003950 NAD+ ADP-ribosyltransferase activity
molecular function GO:0140294 NAD DNA ADP-ribosyltransferase activity
molecular function GO:1990404 protein ADP-ribosylase activity
cellular component GO:0005814 centriole
cellular component GO:0005737 cytoplasm
cellular component GO:0016604 nuclear body
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0035861 site of double-strand break
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4049883 BXGD021954 Obstructive Ureterocele Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0018736 Benzamide 121.05
BXGC0038633 3-Methoxycinnamic acid 178.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein