Showing entry for Voltage-dependent calcium channel gamma-4 subunit


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022653
Protein NameVoltage-dependent calcium channel gamma-4 subunit
Uniport IdQ9UBN1
GeneCACNG4
Gene Id27092
DomainPMP22_Claudin
Pfam PF00822  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0051899 membrane depolarization
Biological Process GO:0099590 neurotransmitter receptor internalization
Biological Process GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome
Biological Process GO:2000969 positive regulation of AMPA receptor activity
Biological Process GO:0051968 positive regulation of synaptic transmission, glutamatergic
Biological Process GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
Biological Process GO:2000311 regulation of AMPA receptor activity
Biological Process GO:0098962 regulation of postsynaptic neurotransmitter receptor activity
Biological Process GO:0042220 response to cocaine
Biological Process GO:0019226 transmission of nerve impulse
molecular function GO:0005246 calcium channel regulator activity
molecular function GO:0016247 channel regulator activity
molecular function GO:0035255 ionotropic glutamate receptor binding
molecular function GO:0005245 voltage-gated calcium channel activity
cellular component GO:0032281 AMPA glutamate receptor complex
cellular component GO:0044297 cell body
cellular component GO:0009986 cell surface
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:1990454 L-type voltage-gated calcium channel complex
cellular component GO:0005886 plasma membrane
cellular component GO:0098839 postsynaptic density membrane
cellular component GO:0036477 somatodendritic compartment
Reactome
Pathway Id Pathway Name
R-HSA-112308 Presynaptic depolarization and calcium channel opening
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-397014 Muscle contraction
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-5576891 Cardiac conduction
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5576893 Phase 2 - plateau phase
R-HSA-5682910 LGI-ADAM interactions
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0343386 BXGD007620 Clostridium difficile infection Infections
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003611 Latex 416.57
BXGC0006372 Ergocalciferol 396.65
BXGC0024988 Nifedipine 346.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein