Showing entry for Small conductance calcium-activated potassium channel protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023455
Protein NameSmall conductance calcium-activated potassium channel protein 2
Uniport IdQ9H2S1
GeneKCNN2
Gene Id3781
DomainCaMBD; Ion_trans_2; SK_channel
Pfam PF02888   PF07885   PF03530  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006811 ion transport
Biological Process GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0006813 potassium ion transport
Biological Process GO:1901379 regulation of potassium ion transmembrane transport
molecular function GO:0051393 alpha-actinin binding
molecular function GO:0015269 calcium-activated potassium channel activity
molecular function GO:0005516 calmodulin binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0016286 small conductance calcium-activated potassium channel activity
cellular component GO:0009986 cell surface
cellular component GO:0043197 dendritic spine
cellular component GO:0016021 integral component of membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296052 Ca2+ activated K+ channels
R-HSA-1296071 Potassium Channels
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0010051 BXGD000646 Coronary Aneurysm Cardiovascular Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0206655 BXGD004218 Alveolar rhabdomyosarcoma Neoplasms
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0596887 BXGD009648 mathematical ability
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2585653 BXGD017139 Persistent atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3468561 BXGD018908 familial atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3536893 BXGD019076 Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein