Showing entry for Nuclear autoantigen Sp-100


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT024062
Protein NameNuclear autoantigen Sp-100
Uniport IdP23497
GeneSP100
Gene Id6672
DomainHMG_box; HMG_box_2; HSR; SAND
Pfam PF00505   PF09011   PF03172   PF01342  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Biological Process GO:0060333 interferon-gamma-mediated signaling pathway
Biological Process GO:0045185 maintenance of protein location
Biological Process GO:0051271 negative regulation of cellular component movement
Biological Process GO:0043392 negative regulation of DNA binding
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0010596 negative regulation of endothelial cell migration
Biological Process GO:0046826 negative regulation of protein export from nucleus
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0032897 negative regulation of viral transcription
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:1902044 regulation of Fas signaling pathway
Biological Process GO:0034097 response to cytokine
Biological Process GO:0034341 response to interferon-gamma
Biological Process GO:0032526 response to retinoic acid
Biological Process GO:0034340 response to type I interferon
Biological Process GO:0048384 retinoic acid receptor signaling pathway
Biological Process GO:0000723 telomere maintenance
Biological Process GO:0060337 type I interferon signaling pathway
Biological Process GO:0016032 viral process
molecular function GO:0070087 chromo shadow domain binding
molecular function GO:0003677 DNA binding
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0042802 identical protein binding
molecular function GO:0019900 kinase binding
molecular function GO:0046983 protein dimerization activity
molecular function GO:0019904 protein domain specific binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0008134 transcription factor binding
cellular component GO:0005737 cytoplasm
cellular component GO:0016604 nuclear body
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0034399 nuclear periphery
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0016605 PML body
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-2990846 SUMOylation
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0017636 BXGD001131 Glioblastoma Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023524 BXGD001681 Leukoencephalopathy, Progressive Multifocal Infections; Nervous System Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0042769 BXGD002999 Virus Diseases Infections
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0268164 BXGD005844 Primary hyperoxaluria, type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0349782 BXGD007954 Ischemic cardiomyopathy Cardiovascular Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C2745900 BXGD017568 Promyelocytic leukemia
C3548479 BXGD019120 response to bronchodilator
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein