Showing entry for Leukoencephalopathy, Progressive Multifocal


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001681
Disease NameLeukoencephalopathy, Progressive Multifocal
Disease CUI IdC0023524
MeSH Codes C01   C10  
Disease Class NameInfections; Nervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:0050117  
Disease Ontology Class Namedisease by infectious agent
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O00213 BXGT003896 Amyloid-beta A4 precursor protein-binding family B member 1 322 reviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14980 BXGT004119 Exportin-1 7514 reviewed Receptor
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O43913 BXGT004634 Origin recognition complex subunit 5 5001 reviewed Nucleic acid binding
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O94811 BXGT005336 Tubulin polymerization-promoting protein 11076 reviewed Cellular structure
O95644 BXGT005389 Nuclear factor of activated T-cells, cytoplasmic 1 4772 reviewed Transcription factor
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01574 BXGT005768 Interferon beta 3456 reviewed
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04156 BXGT006156 Major prion protein 5621 reviewed
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05120 BXGT006319 Plasminogen activator inhibitor 2 5055 reviewed Enzyme modulator
P05161 BXGT006331 Ubiquitin-like protein ISG15 9636 reviewed Nucleic acid binding
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P06748 BXGT006497 Nucleophosmin 4869 reviewed Chaperone
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07355 BXGT006609 Annexin A2 302 reviewed
P07602 BXGT006646 Prosaposin 5660 reviewed
P08246 BXGT006756 Neutrophil elastase 1991 reviewed Enzyme
P08311 BXGT006762 Cathepsin G 1511 reviewed Enzyme
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10276 BXGT007553 Retinoic acid receptor alpha 5914 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10646 BXGT007598 Tissue factor pathway inhibitor 7035 reviewed Enzyme modulator
P10826 BXGT007622 Retinoic acid receptor beta 5915 reviewed Nuclear receptor
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P17676 BXGT008327 CCAAT/enhancer-binding protein beta 1051 reviewed Transcription factor
P17735 BXGT008335 Tyrosine aminotransferase 6898 reviewed
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19793 BXGT008515 Retinoic acid receptor RXR-alpha 6256 reviewed Nuclear receptor
P20701 BXGT008591 Integrin alpha-L 3683 reviewed
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P22314 BXGT008755 Ubiquitin-like modifier-activating enzyme 1 7317 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P28223 BXGT009239 5-hydroxytryptamine receptor 2A 3356 reviewed G-protein coupled receptor
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P49913 BXGT010761 Cathelicidin antimicrobial peptide 820 reviewed
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P55211 BXGT011111 Caspase-9 842 reviewed Enzyme
P63165 BXGT011506 Small ubiquitin-related modifier 1 7341 reviewed
P68871 BXGT011615 Hemoglobin subunit beta 3043 reviewed
P78317 BXGT011831 E3 ubiquitin-protein ligase RNF4 6047 reviewed
P78504 BXGT011844 Protein jagged-1 182 reviewed
Q00534 BXGT012533 Cyclin-dependent kinase 6 1021 reviewed Kinase
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q03405 BXGT012713 Urokinase plasminogen activator surface receptor 5329 reviewed
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q05516 BXGT012822 Zinc finger and BTB domain-containing protein 16 7704 reviewed Transcription factor
Q05655 BXGT012832 Protein kinase C delta type 5580 reviewed Kinase
Q06609 BXGT012884 DNA repair protein RAD51 homolog 1 5888 reviewed
Q07955 BXGT012951 Serine/arginine-rich splicing factor 1 6426 reviewed Nucleic acid binding
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q13535 BXGT013370 Serine/threonine-protein kinase ATR 545 reviewed Kinase
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q14289 BXGT013459 Protein-tyrosine kinase 2-beta 2185 reviewed Kinase
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15022 BXGT013523 Polycomb protein SUZ12 23512 reviewed Nucleic acid binding
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15431 BXGT013571 Synaptonemal complex protein 1 6847 reviewed
Q15554 BXGT013577 Telomeric repeat-binding factor 2 7014 reviewed
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16666 BXGT013654 Gamma-interferon-inducible protein 16 3428 reviewed Transcription factor
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q6P2Q9 BXGT016446 Pre-mRNA-processing-splicing factor 8 10594 reviewed Nucleic acid binding
Q8IVA8 BXGT018342 Glutamate decarboxylase 1 (Brain, 67kDa) 2571 unreviewed
Q92616 BXGT019358 eIF-2-alpha kinase activator GCN1 10985 reviewed Enzyme modulator
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q92794 BXGT019375 Histone acetyltransferase KAT6A 7994 reviewed Enzyme
Q92993 BXGT019403 Histone acetyltransferase KAT5 10524 reviewed
Q93009 BXGT019455 Ubiquitin carboxyl-terminal hydrolase 7 7874 reviewed Enzyme
Q99259 BXGT019915 Glutamate decarboxylase 1 2571 reviewed Enzyme
Q99653 BXGT019945 Calcineurin B homologous protein 1 11261 reviewed
Q9BUB5 BXGT020133 MAP kinase-interacting serine/threonine-protein kinase 1 8569 reviewed Kinase
Q9GZU7 BXGT020426 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 58190 reviewed
Q9H0P0 BXGT020439 Cytosolic 5'-nucleotidase 3A 51251 reviewed Enzyme
Q9H2X6 BXGT020458 Homeodomain-interacting protein kinase 2 28996 reviewed Kinase
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9P0U3 BXGT021292 Sentrin-specific protease 1 29843 reviewed Enzyme
Q9UER7 BXGT021672 Death domain-associated protein 6 1616 reviewed
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9UM07 BXGT021771 Protein-arginine deiminase type-4 23569 reviewed
Q9Y6K9 BXGT022333 NF-kappa-B essential modulator 8517 reviewed Kinase
Q9Y6Q9 BXGT022338 Nuclear receptor coactivator 3 8202 reviewed Kinase
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P23497 BXGT024062 Nuclear autoantigen Sp-100 6672 reviewed
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
P29590 BXGT024350 Protein PML 5371 reviewed
P21926 BXGT024578 CD9 antigen 928 reviewed
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease