Showing entry for Piperlongine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0001428
Compound NamePiperlongine
Structure
FormulaC17H19NO5
InchiKeyVABYUUZNAVQNPG-BQYQJAHWSA-N
SMILESCOC1=CC(\C=C\C(=O)N2CCC=CC2=O)=CC(OC)=C1OC
InchiInChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
IUPAC1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-1,2,5,6-tetrahydropyridin-2-one
Molecular Weight317.34
Pubchem Id637858
Chembl IdCHEMBL465843
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL465843
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 7943 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 6309 nM
O75030 BXGT005096 Microphthalmia-associated transcription factor reviewed - MITF AC50 '=' 7403 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 22387 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 10000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 2592 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 25118 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 8912 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 50 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 3548 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 14125 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 8199 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 29092 nM
Q923J1 BXGT019344 Transient receptor potential cation channel subfamily M member 7 reviewed - Trpm7 Inhibition - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 2310 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 15848 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 2059 nM
Q06710 BXGT012887 Paired box protein Pax-8 reviewed - PAX8 AC50 '=' 2690 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 19952 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 10000 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 35481 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 1835 nM
Q06710 BXGT012887 Paired box protein Pax-8 reviewed - PAX8 AC50 '=' 60530 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 10000 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 3981 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 39810 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 25118 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 3162 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 25118 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 4109 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 5804 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 89125 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 28183 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 2238 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 6309 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 2511 nM
P35222 BXGT009799 Catenin beta-1 reviewed - CTNNB1 Inhibition - - -
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Inhibition - - -
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 5011 nM
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B Inhibition - - -
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 Activity - - -
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 Inhibition - - -
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 Ratio '=' 0 -
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 Ratio '=' 0 -
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 Ratio '=' 0 -
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 Ratio '=' 0 -
Q8N573 BXGT026157 Oxidation resistance protein 1 reviewed - OXR1 Activity - - -
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 IC50 '=' 7000 nM
P40763 BXGT010202 Signal transducer and activator of transcription 3 reviewed Nucleic acid binding STAT3 Inhibition - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00139 Pepper (Spice) Piper nigrum Herbs and Spices
BXGF00818 Herbs and Spices Herbs and Spices
BXGF00943 Brickellia longifolia Brickellia longifolia Others
BXGF00976 Verbesina virginica Verbesina virginica Others
BXGF00991 Galium verum Galium verum Medicinal Plant
BXGF01044 Bellardia viscosa Bellardia viscosa Others
BXGF01072 Dichotomanthes tristaniicarpa Dichotomanthes tristaniicarpa Others
BXGF01165 Cochlearia officinalis Cochlearia officinalis Medicinal Plant
BXGF01368 Frullania brasiliensis Frullania brasiliensis Medicinal Plant
BXGF01396 Bupleurum rigidum Bupleurum rigidum Medicinal Plant
BXGF01504 Gymnadenia conopsea Gymnadenia conopsea Medicinal Plant
BXGF01531 Abies webbiana Abies webbiana Medicinal Plant
BXGF02461 Kopsia lapidilecta Kopsia lapidilecta Others
BXGF02492 Dryopteris arguta Dryopteris arguta Human Edible Plant
BXGF02771 Plenckia populnea Plenckia populnea Others
BXGF03507 Pinus aristata Pinus aristata Medicinal Plant
BXGF03575 Palisota barteri Palisota barteri Others
BXGF03737 Matsumurella chinensis Matsumurella chinensis Others
BXGF04193 Piper longum Piper longum Medicinal Plant
BXGF04427 Silene banksia Silene banksia Others
BXGF04642 Podocarpus minor Podocarpus minor Others
BXGF05127 Robinia pseudoacacia Robinia pseudoacacia Medicinal Plant
BXGF05189 Dracontium loretense Dracontium loretense Others
BXGF05648 Euphorbia wangii Euphorbia wangii Others
BXGF05671 Carpesium longifolium Carpesium longifolium Medicinal Plant
BXGF05694 Piper retrofractum Piper retrofractum Medicinal Plant
BXGF05741 Crocus corsicus Crocus corsicus Others
BXGF05792 Schefflera venulosa Schefflera venulosa Medicinal Plant
BXGF06264 Homalium laurifolium Homalium laurifolium Others
BXGF06298 Hippocrepis emerus Hippocrepis emerus Others
BXGF06316 Coelogyne nitida Coelogyne nitida Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease