Showing entry for Physcion


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0007749
Compound NamePhyscion
Structure
FormulaC16H12O5
InchiKeyFFWOKTFYGVYKIR-UHFFFAOYSA-N
SMILESCOC1=CC2=C(C(O)=C1)C(=O)C1=C(C=C(C)C=C1O)C2=O
InchiInChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
IUPAC1,8-dihydroxy-3-methoxy-6-methyl-9,10-dihydroanthracene-9,10-dione
Molecular Weight284.26
Pubchem Id10639
Chembl IdCHEMBL42624
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50005886
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK - >8 - -
reviewed BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed Txnrd1 - 185000 - -
reviewed BXGT022399 Thioredoxin reductase 2, mitochondrial reviewed Txnrd2 - 132000 - -
reviewed BXGT006756 Neutrophil elastase reviewed Enzyme ELANE - 6200 - -
reviewed BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 >10000 - - -
CHEMBL CHEMBL42624
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P00784 BXGT005655 Papain reviewed - IC50 - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 3548 nM
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 '=' 6200 nM
P23739 BXGT008901 Sucrase-isomaltase, intestinal reviewed - Si Inhibition - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 112 %
P06280 BXGT006433 Alpha-galactosidase A reviewed - GLA Potency '=' 35481 nM
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Inhibition '=' 100 %
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 12589 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 35481 nM
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Inhibition '=' 39 %
P16234 BXGT008209 Platelet-derived growth factor receptor alpha reviewed Kinase PDGFRA Activity - - -
P09619 BXGT006911 Platelet-derived growth factor receptor beta reviewed Kinase PDGFRB Activity - - -
Q9H244 BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 Inhibition '=' 7 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '=' 94 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '=' 94 %
P00766 BXGT005647 Chymotrypsinogen A reviewed - Inhibition '=' - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '=' 104 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '=' 104 %
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 '>' 800 ug.mL-1
Q4U254 BXGT014890 Protease unreviewed - protease IC50 '>' 150000 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 14125 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 IC50 '=' 185000 nM
Q9H244 BXGT020448 P2Y purinoceptor 12 reviewed G-protein coupled receptor P2RY12 Ki '>' 10000 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 111 %
P08419 BXGT006770 Chymotrypsin-like elastase family member 2A reviewed - CELA2A Inhibition - - -
O43451 BXGT004594 Maltase-glucoamylase, intestinal reviewed Enzyme MGAM Inhibition - - -
Q9Z0J5 BXGT022399 Thioredoxin reductase 2, mitochondrial reviewed - Txnrd2 IC50 '=' 132000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '=' 99 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '=' 99 %
P34913 BXGT009770 Bifunctional epoxide hydrolase 2 reviewed Enzyme EPHX2 Inhibition '=' 27 %
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 22387 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 39810 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 44668 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 28183 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00037 Pigeon pea Cajanus cajan Pulses
BXGF00111 Cornmint Mentha arvensis Herbs and Spices
BXGF00154 Garden rhubarb Rheum rhabarbarum Vegetables
BXGF00164 Sorrel Rumex acetosa Herbs and Spices
BXGF00165 Common sage Salvia officinalis Herbs and Spices
BXGF00459 Wax gourd Benincasa hispida Gourds
BXGF00892 Leptocereus quadricostatus Leptocereus quadricostatus Others
BXGF00896 Magnolia figo Magnolia figo Human Edible Plant
BXGF00919 Chaiturus marrubiastrum Chaiturus marrubiastrum Others
BXGF00981 Flacourtia jangomas Flacourtia jangomas Medicinal Plant
BXGF00997 Bletilla striata Bletilla striata Medicinal Plant
BXGF01091 Rubus alceifolius Rubus alceifolius Human Edible Plant
BXGF01126 Polygonum cuspidatum Polygonum cuspidatum Medicinal Plant
BXGF01187 Onobrychis arenaria Onobrychis arenaria Others
BXGF01223 Eria mollis Eria mollis Others
BXGF01231 Pluchea sericea Pluchea sericea Human Edible Plant
BXGF01267 Dendrobium chrysanthum Dendrobium chrysanthum Medicinal Plant
BXGF01302 Dysoxylum cumingianum Dysoxylum cumingianum Others
BXGF01311 Aizopsis selskiana Aizopsis selskiana Others
BXGF01344 Psychotria stachyoides Psychotria stachyoides Others
BXGF01356 Senna occidentalis Senna occidentalis Medicinal Plant
BXGF01357 Ampelopsis japonica Ampelopsis japonica Medicinal Plant
BXGF01391 Dodonaea viscosa Dodonaea viscosa Medicinal Plant
BXGF01473 Siphonostegia chinensis Siphonostegia chinensis Medicinal Plant
BXGF01474 Rheum australe Rheum australe Medicinal Plant
BXGF01495 Pleione yunnanensis Pleione yunnanensis Others
BXGF01541 Rumex patientia Rumex patientia Medicinal Plant
BXGF01568 Teucrium yemense Teucrium yemense Others
BXGF01570 Pinalia stricta Pinalia stricta Others
BXGF01623 Amphorogyne spicata Amphorogyne spicata Others
BXGF01641 Neobalanocarpus heimii Neobalanocarpus heimii Others
BXGF01671 Ipomoea muelleri Ipomoea muelleri Human Edible Plant
BXGF01683 Aconitum tasiromontanum Aconitum tasiromontanum Others
BXGF01695 Tanacetum coccineum Tanacetum coccineum Medicinal Plant
BXGF01716 Mentha canadensis Mentha canadensis Medicinal Plant
BXGF01764 Dendriopoterium menendezii Dendriopoterium menendezii Others
BXGF01794 Adansonia grandidieri Adansonia grandidieri Human Edible Plant
BXGF01799 Mandragora autumnalis Mandragora autumnalis Medicinal Plant
BXGF01812 Physalis alkekengi Physalis alkekengi Medicinal Plant
BXGF01836 Aphyllocladus denticulatus Aphyllocladus denticulatus Others
BXGF01850 Bassia muricata Bassia muricata Medicinal Plant
BXGF01889 Arabidopsis lyrata subsp. lyrata Arabidopsis lyrata subsp. lyrata Others
BXGF01915 Vismia laurentii Vismia laurentii Medicinal Plant
BXGF01931 Dalbergia lanceolaria subsp. paniculata Dalbergia lanceolaria subsp. paniculata Medicinal Plant
BXGF01937 Thapsia transtagana Thapsia transtagana Others
BXGF01947 Senecio subdentatus Senecio subdentatus Others
BXGF02006 Aconitum seravschanicum Aconitum seravschanicum Others
BXGF02037 Carduus tenuiflorus Carduus tenuiflorus Others
BXGF02039 Abutilon grandiflorum Abutilon grandiflorum Medicinal Plant
BXGF02169 Pristimera indica Pristimera indica Medicinal Plant
BXGF02203 Verbascum thapsiforme Verbascum thapsiforme Medicinal Plant
BXGF02256 Rumex chalepensis Rumex chalepensis Others
BXGF02289 Rhododendron dahuricum Rhododendron dahuricum Others
BXGF02357 Euodia bodinieri Euodia bodinieri Others
BXGF02387 Salvia greggii Salvia greggii Medicinal Plant
BXGF02470 Thryptomene kochii Thryptomene kochii Others
BXGF02496 Pleione bulbocodioides Pleione bulbocodioides Others
BXGF02499 Cremastra appendiculata Cremastra appendiculata Medicinal Plant
BXGF02503 Balanophora laxiflora Balanophora laxiflora Others
BXGF02561 Dysosma versipellis Dysosma versipellis Medicinal Plant
BXGF02566 Fridericia triplinervia Fridericia triplinervia Others
BXGF02576 Anaphalis lactea Anaphalis lactea Others
BXGF02605 Viburnum rhytidophyllum Viburnum rhytidophyllum Others
BXGF02632 Metrodorea nigra Metrodorea nigra Others
BXGF02701 Euphorbia aellenii Euphorbia aellenii Others
BXGF02727 Prunus japonica Prunus japonica Medicinal Plant
BXGF02764 Valeriana cardamines Valeriana cardamines Others
BXGF02814 Senecio praecox Senecio praecox Others
BXGF02817 Garcinia polyantha Garcinia polyantha Medicinal Plant
BXGF02824 Uncaria lancifolia Uncaria lancifolia Others
BXGF02851 Aniba parviflora Aniba parviflora Human Edible Plant
BXGF02853 Anchusa azurea Anchusa azurea Medicinal Plant
BXGF02880 Nepeta granatensis Nepeta granatensis Others
BXGF02900 Gleichenia quadripartita Gleichenia quadripartita Others
BXGF02932 Dipsacus azureus Dipsacus azureus Others
BXGF02936 Quercus variabilis Quercus variabilis Medicinal Plant
BXGF02944 Liabum bourgeaui Liabum bourgeaui Others
BXGF02958 Jacquemontia paniculata Jacquemontia paniculata Others
BXGF02978 Tetradium ruticarpum Tetradium ruticarpum Medicinal Plant
BXGF02993 Caulerpa peltata Caulerpa peltata Human Edible Plant
BXGF03028 Lespedeza tomentosa Lespedeza tomentosa Medicinal Plant
BXGF03042 Rosa pomifera Rosa pomifera Human Edible Plant
BXGF03064 Degenia velebitica Degenia velebitica Others
BXGF03077 Albizia myriophylla Albizia myriophylla Medicinal Plant
BXGF03088 Erythrophleum ivorense Erythrophleum ivorense Medicinal Plant
BXGF03114 Delphinium virgatum Delphinium virgatum Others
BXGF03135 Grangea maderaspatana Grangea maderaspatana Medicinal Plant
BXGF03158 Rheum officinale Rheum officinale Medicinal Plant
BXGF03161 Dendrobium chrysotoxum Dendrobium chrysotoxum Medicinal Plant
BXGF03167 Tagetes filifolia Tagetes filifolia Medicinal Plant
BXGF03217 Delphinium nuttallianum Delphinium nuttallianum Others
BXGF03251 Lupinus corymbosus Lupinus corymbosus Others
BXGF03298 Senecio behnii Senecio behnii Others
BXGF03317 Dillenia indica Dillenia indica Medicinal Plant
BXGF03346 Dendrobium candidum Dendrobium candidum Others
BXGF03436 Photinia serratifolia Photinia serratifolia Medicinal Plant
BXGF03485 Justicia secunda Justicia secunda Others
BXGF03512 Helichrysum chionosphaerum Helichrysum chionosphaerum Medicinal Plant
BXGF03632 Dendrobium fimbriatum Dendrobium fimbriatum Medicinal Plant
BXGF03683 Cynanchum viminale Cynanchum viminale Medicinal Plant
BXGF03748 Ventilago leiocarpa Ventilago leiocarpa Medicinal Plant
BXGF03855 Rumex dentatus Rumex dentatus Medicinal Plant
BXGF03988 Rheum coreanum Rheum coreanum Others
BXGF04057 Abrus pulchellus Abrus pulchellus Medicinal Plant
BXGF04062 Spatholobus suberectus Spatholobus suberectus Medicinal Plant
BXGF04064 Rumex japonicus Rumex japonicus Medicinal Plant
BXGF04100 Harungana madagascariensis Harungana madagascariensis Medicinal Plant
BXGF04205 Aster sedifolius Aster sedifolius Others
BXGF04229 Petunia integrifolia subsp. inflata Petunia integrifolia subsp. inflata Others
BXGF04231 Andrographis neesiana Andrographis neesiana Others
BXGF04244 Coreopsis tinctoria Coreopsis tinctoria Medicinal Plant
BXGF04258 Rubia cordifolia Rubia cordifolia Medicinal Plant
BXGF04340 Quercus rubra Quercus rubra Medicinal Plant
BXGF04351 Baccharis potosina Baccharis potosina Others
BXGF04395 Maclura tinctoria Maclura tinctoria Medicinal Plant
BXGF04413 Gynochthodes officinalis Gynochthodes officinalis Others
BXGF04438 Stevia berlandieri Stevia berlandieri Others
BXGF04499 Ravenia spectabilis Ravenia spectabilis Others
BXGF04539 Rheum palmatum Rheum palmatum Medicinal Plant
BXGF04577 Poterium sanguisorba Poterium sanguisorba Medicinal Plant
BXGF04605 Senna alexandrina Senna alexandrina Medicinal Plant
BXGF04665 Magnolia ovata Magnolia ovata Others
BXGF04698 Isodon rubescens Isodon rubescens Others
BXGF04713 Aster tataricus Aster tataricus Medicinal Plant
BXGF04811 Sinocrassula indica Sinocrassula indica Others
BXGF04837 Nekemias grossedentata Nekemias grossedentata Others
BXGF04881 Fallopia multiflora Fallopia multiflora Medicinal Plant
BXGF04886 Boehmeria nivea Boehmeria nivea Medicinal Plant
BXGF04912 Corydalis rhizoma Corydalis rhizoma Others
BXGF04914 Cassia acutifolia Cassia acutifolia Medicinal Plant
BXGF04917 Cassia obtusifolia Cassia obtusifolia Medicinal Plant
BXGF04936 Cassia occidentalis Cassia occidentalis Medicinal Plant
BXGF04937 Toxicopueraria peduncularis Toxicopueraria peduncularis Others
BXGF04968 Cassia angustifolia Cassia angustifolia Medicinal Plant
BXGF04974 Morinda officinalis Morinda officinalis Others
BXGF04984 Selaginella labordei Selaginella labordei Others
BXGF04990 Cassia tora Cassia tora Medicinal Plant
BXGF05018 Lavandula vera Lavandula vera Medicinal Plant
BXGF05022 rumex plants rumex plants Others
BXGF05051 Rhamnus Rhamnus Medicinal Plant
BXGF05173 Dendrobium nobile Dendrobium nobile Medicinal Plant
BXGF05183 Lanaria lanata Lanaria lanata Others
BXGF05192 Frangula purshiana Frangula purshiana Medicinal Plant
BXGF05224 Cranfillia fluviatilis Cranfillia fluviatilis Medicinal Plant
BXGF05356 Euodia officinalis Euodia officinalis Others
BXGF05511 Acorus gramineus Acorus gramineus Medicinal Plant
BXGF05524 Rumex nepalensis Rumex nepalensis Medicinal Plant
BXGF05647 Betula davurica Betula davurica Others
BXGF05802 Scilla socialis Scilla socialis Others
BXGF05877 Rheum tanguticum Rheum tanguticum Medicinal Plant
BXGF05886 Senna tora Senna tora Medicinal Plant
BXGF06002 Euodia ruticarpa Euodia ruticarpa Others
BXGF06011 Enceliopsis argophylla Enceliopsis argophylla Others
BXGF06069 Dendrobium loddigesii Dendrobium loddigesii Medicinal Plant
BXGF06071 Acorus tatarinowii Acorus tatarinowii Medicinal Plant
BXGF06095 Rheum undulatum Rheum undulatum Medicinal Plant
BXGF06114 Senna obtusifolia Senna obtusifolia Medicinal Plant
BXGF06281 Miliusa velutina Miliusa velutina Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease