Showing entry for Bifunctional epoxide hydrolase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009770
Protein NameBifunctional epoxide hydrolase 2
Uniport IdP34913
GeneEPHX2
Gene Id2053
DomainAbhydrolase_1; Hydrolase
Pfam PF00561   PF13419  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.1 Transport and catabolism hsa04146 Peroxisome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0016311 dephosphorylation
Biological Process GO:0097176 epoxide metabolic process
Biological Process GO:0019373 epoxygenase P450 pathway
Biological Process GO:0042759 long-chain fatty acid biosynthetic process
Biological Process GO:0046839 phospholipid dephosphorylation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0006625 protein targeting to peroxisome
Biological Process GO:0090181 regulation of cholesterol metabolic process
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0046272 stilbene catabolic process
molecular function GO:0033885 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
molecular function GO:0004301 epoxide hydrolase activity
molecular function GO:0016787 hydrolase activity
molecular function GO:0042577 lipid phosphatase activity
molecular function GO:0052642 lysophosphatidic acid phosphatase activity
molecular function GO:0000287 magnesium ion binding
molecular function GO:0016791 phosphatase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0015643 toxic substance binding
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005782 peroxisomal matrix
cellular component GO:0005777 peroxisome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
R-HSA-9018677 Biosynthesis of DHA-derived SPMs
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
R-HSA-9018682 Biosynthesis of maresins
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033241 Peroxisomal protein import
R-HSA-9609507 Protein localization
R-HSA-9609507 Protein localization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003125 BXGD000179 Anorexia Nervosa Mental Disorders
C0003742 BXGD000218 Arcus Senilis Eye Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028960 BXGD002101 Oligospermia Male Urogenital Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035344 BXGD002541 Retinopathy of Prematurity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038160 BXGD002734 Staphylococcal Infections Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0155210 BXGD003780 Eyelid Xanthoma Nutritional and Metabolic Diseases; Eye Diseases
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242488 BXGD005170 Acute Lung Injury Respiratory Tract Diseases
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0302314 BXGD006837 Xanthoma Nutritional and Metabolic Diseases
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0403823 BXGD008315 Asthenozoospermia Male Urogenital Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0752347 BXGD010721 Lewy Body Disease Nervous System Diseases; Mental Disorders
C0861352 BXGD011246 Lobular Neoplasia Neoplasms; Skin and Connective Tissue Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565662 BXGD013402 Acute Kidney Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1868702 BXGD016529 Diabetic keratopathy
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3805043 BXGD019457 Vascular cognitive impairment
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0001837 Quercetin 3-rutinoside 610.52
BXGC0001881 Chrysophanol 254.24
BXGC0001918 3,5-Di-O-caffeoylquinic acid 516.45
BXGC0001994 Hyperin 464.38
BXGC0002061 Aloeemodin 270.24
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0003772 Corilagin 634.45
BXGC0003788 Phlororrhizin 436.41
BXGC0004580 Carbanilide 212.25
BXGC0005497 Syringin 372.37
BXGC0005683 Quercetin 302.24
BXGC0006155 Chrysoobtusin 358.34
BXGC0006193 Ellagic acid 302.19
BXGC0007029 Emodin 270.24
BXGC0007749 Physcion 284.26
BXGC0008753 Isoquercitrin 464.38
BXGC0008824 Astragalin 448.38
BXGC0009126 Myricetin 3-glucoside 480.38
BXGC0013714 1,3-Dicyclohexylurea 224.19
BXGC0014231 Isoquercitin 2''-O-Gallate 616.11
BXGC0017496 Methyl Ferulate 208.07
BXGC0018749 Chryso-obtusin glucoside 520.16
BXGC0026157 Gluco-Obtusifolin 446.12
BXGC0026345 n.a 448.23
BXGC0027988 Gluco-Aurantioobtusin 492.13
BXGC0028091 Rubrofusarin-6-O-Gentiobioside 596.17
BXGC0028940 Aloin B 418.13
BXGC0029887 n.a 199.1
BXGC0029888 9-heptadecanone 254.26
BXGC0031694 1,3,4,6-Tetra-O-Galloyl-Beta-D-Glucopyranoside 788.11
BXGC0034626 rubrofusarin-6-glucoside 434.12
BXGC0035530 n.a 686.16
BXGC0038030 cimiracemate A 358.11
BXGC0039831 Astragalin 2'',3''-O-Digallate 752.12
BXGC0040556 Methylconiferin 356.15
BXGC0040619 obtusifolin 284.07
BXGC0042918 Quercitrin 2''-O-Gallate 600.11
BXGC0043238 Obtusin 344.09
BXGC0044706 Physcion-8-O-Gentiobioside 608.17
BXGC0045744 n.a 314.08
BXGC0045745 n.a 556.18
BXGC0046599 Aloin 418.13
BXGC0047294 Aloinoside B 564.18
BXGC0047368 aurantio-obtusin 330.07
BXGC0048458 Astragalin 2''-O-Gallate 600.11
BXGC0048620 Toralactone-9-O-Gentiobioside 596.17
BXGC0052645 (S)-Brevifolin Carboxylic Acid 292.02
BXGC0052881 (S)-Methyl Brevifolin Carboxylate 306.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein