acompound

Showing entry for Kaempferide

General Compound Information
BXGC Id	BXGC0008840
Compound Name	Kaempferide
Structure
Formula	C16H12O6
InchiKey	SQFSKOYWJBQGKQ-UHFFFAOYSA-N
SMILES	COC1=CC=C(C=C1)C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1
Inchi	InChI=1S/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3
IUPAC	3,5,7-trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
Molecular Weight	300.26
Pubchem Id	5281666
Chembl Id	CHEMBL40919

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

50084978

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT013634	Mitogen-activated protein kinase 14	reviewed	Kinase	MAPK14	-	32900	-	-
reviewed	BXGT011014	Mitogen-activated protein kinase 10	reviewed	Kinase	MAPK10	-	52500	-	-
reviewed	BXGT008651	ATP-dependent translocase ABCB1	reviewed		Abcb1a	-	-	5000	-
reviewed	BXGT004563	Polyphenol oxidase 2	reviewed		PPO2	-	>100000	-	-
reviewed	BXGT007329	DNA gyrase subunit A	reviewed		gyrA	-	>1660000	-	-
reviewed	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	-	88	-	-
reviewed	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	-	25	-	-
reviewed	BXGT008651	ATP-dependent translocase ABCB1	reviewed		Abcb1a	-	-	4500	-
reviewed	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	-	300	-	-
reviewed	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	-	6	-	-
reviewed	BXGT006741	ATP-dependent translocase ABCB1	reviewed	Transporter	ABCB1	-	-	4467	-

CHEMBL

CHEMBL40919

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q16678	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	IC50	'='	6	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	IC50	'='	509	nM
Q16678	BXGT013656	Cytochrome P450 1B1	reviewed	Enzyme	CYP1B1	IC50	'='	25	nM
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	reviewed	Enzyme	NFE2L2	Activity	-	-	-
P04798	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	IC50	'='	300	nM
P21447	BXGT008651	ATP-dependent translocase ABCB1	reviewed	-	Abcb1a	Kd	'='	5000	nM
P08183	BXGT006741	ATP-dependent translocase ABCB1	reviewed	Transporter	ABCB1	Kd	'='	4466	nM
P21447	BXGT008651	ATP-dependent translocase ABCB1	reviewed	-	Abcb1a	Kd	'='	4500	nM
O42713	BXGT004563	Polyphenol oxidase 2	reviewed	-	PPO2	Inhibition	'='	1	%
O42713	BXGT004563	Polyphenol oxidase 2	reviewed	-	PPO2	IC50	'>'	100000	nM
P04798	BXGT006265	Cytochrome P450 1A1	reviewed	Enzyme	CYP1A1	IC50	'='	88	nM
Q02880	BXGT012677	DNA topoisomerase 2-beta	reviewed	-	TOP2B	CC50	-	-	-
Q86831	BXGT017584	Polyprotein II	unreviewed	-		Inhibition	'='	64	%
O42713	BXGT004563	Polyphenol oxidase 2	reviewed	-	PPO2	Inhibition	'='	-1	%
O42713	BXGT004563	Polyphenol oxidase 2	reviewed	-	PPO2	Inhibition	'='	0	%
P0AES4	BXGT007329	DNA gyrase subunit A	reviewed	-	gyrA	IC50	'>'	500	ug.mL-1
P0AES6	BXGT007331	DNA gyrase subunit B	reviewed	-	gyrB	IC50	'>'	500	ug.mL-1
O42713	BXGT004563	Polyphenol oxidase 2	reviewed	-	PPO2	Inhibition	'='	-5	%
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	IC50	'='	3000	nM
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	reviewed	Transporter	ABCG2	Activity	-	-	-
P21447	BXGT008651	ATP-dependent translocase ABCB1	reviewed	-	Abcb1a	Delta Fmax	'='	96	%
O42713	BXGT004563	Polyphenol oxidase 2	reviewed	-	PPO2	Inhibition	'='	0	%
Q04206	BXGT012754	Transcription factor p65	reviewed	Transcription factor	RELA	Inhibition	-	-	-
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	reviewed	Transcription factor	NFKB1	Inhibition	-	-	-
Q00653	BXGT012541	Nuclear factor NF-kappa-B p100 subunit	reviewed	Transcription factor	NFKB2	Inhibition	-	-	-

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00063	Saffron	Crocus sativus	Herbs and Spices
BXGF00146	Sour cherry	Prunus cerasus	Fruits
BXGF00147	European plum	Prunus domestica	Fruits
BXGF00179	Cloves	Syzygium aromaticum	Herbs and Spices
BXGF00818	Herbs and Spices		Herbs and Spices
BXGF00822	Beverages		Beverages
BXGF00823	Fruits		Fruits
BXGF00948	Artemisia apiacea	Artemisia apiacea	Medicinal Plant
BXGF01104	Garcinia cambogia	Garcinia cambogia	Medicinal Plant
BXGF01245	Amomum villosum	Amomum villosum	Medicinal Plant
BXGF01252	Petasites laevigatus	Petasites laevigatus	Medicinal Plant
BXGF01404	Sphaeranthus confertifolius	Sphaeranthus confertifolius	Others
BXGF01556	Ornithoglossum viride	Ornithoglossum viride	Others
BXGF01606	Schizanthus tricolor	Schizanthus tricolor	Others
BXGF01631	Anodendron affine	Anodendron affine	Medicinal Plant
BXGF01669	Hertia cheirifolia	Hertia cheirifolia	Others
BXGF01720	Cedrela salvadorensis	Cedrela salvadorensis	Others
BXGF01902	Amomum longiligulare	Amomum longiligulare	Medicinal Plant
BXGF02238	Amomum xanthioides	Amomum xanthioides	Medicinal Plant
BXGF02317	Krameria parvifolia	Krameria parvifolia	Others
BXGF02328	Dalbergia nitidula	Dalbergia nitidula	Medicinal Plant
BXGF02372	Aesculus turbinata	Aesculus turbinata	Medicinal Plant
BXGF02390	Argyreia speciosa	Argyreia speciosa	Medicinal Plant
BXGF02465	Vernonia profuga	Vernonia profuga	Others
BXGF02578	Artocarpus styracifolius	Artocarpus styracifolius	Human Edible Plant
BXGF02775	Aconitum contortum	Aconitum contortum	Others
BXGF02779	Swertia chinensis	Swertia chinensis	Medicinal Plant
BXGF02821	Forsythia giraldiana	Forsythia giraldiana	Others
BXGF02892	Dorstenia mannii	Dorstenia mannii	Medicinal Plant
BXGF02938	Uvaria lucida	Uvaria lucida	Human Edible Plant
BXGF03216	Neolitsea villosa	Neolitsea villosa	Others
BXGF03382	Tamarix chinensis	Tamarix chinensis	Medicinal Plant
BXGF03454	Saussurea salicifolia	Saussurea salicifolia	Others
BXGF03527	Alpinia oxyphylla	Alpinia oxyphylla	Medicinal Plant
BXGF03554	Kaempferia galanga	Kaempferia galanga	Medicinal Plant
BXGF03560	Alnus alnobetula	Alnus alnobetula	Others
BXGF03600	Callistemon coccineus	Callistemon coccineus	Others
BXGF03622	Justicia betonica	Justicia betonica	Medicinal Plant
BXGF03636	Hypericum reptans	Hypericum reptans	Others
BXGF03655	Uncaria africana	Uncaria africana	Medicinal Plant
BXGF03670	Strychnos amazonica	Strychnos amazonica	Medicinal Plant
BXGF03687	Alpinia zerumbet	Alpinia zerumbet	Medicinal Plant
BXGF03701	Escontria chiotilla	Escontria chiotilla	Human Edible Plant
BXGF03719	Rubus laciniatus	Rubus laciniatus	Medicinal Plant
BXGF03733	Alpinia officinarum	Alpinia officinarum	Medicinal Plant
BXGF03755	Eucryphia cordifolia	Eucryphia cordifolia	Others
BXGF03770	Buxus hildebrandtii	Buxus hildebrandtii	Others
BXGF03778	Drypetes tessmanniana	Drypetes tessmanniana	Others
BXGF03790	Pteryxia terebinthina	Pteryxia terebinthina	Others
BXGF03805	Gratiola officinalis	Gratiola officinalis	Medicinal Plant
BXGF03818	Rhizophora tagal	Rhizophora tagal	Others
BXGF03825	Salvia lavandulifolia	Salvia lavandulifolia	Medicinal Plant
BXGF03835	Echinacea simulata	Echinacea simulata	Others
BXGF03850	Cotinus coggygria	Cotinus coggygria	Medicinal Plant
BXGF03854	Grindelia discoidea	Grindelia discoidea	Others
BXGF03869	Eremurus chinensis	Eremurus chinensis	Others
BXGF03900	Pachygone dasycarpa	Pachygone dasycarpa	Others
BXGF03905	Croton geayi	Croton geayi	Others
BXGF03918	Callicarpa acuminata	Callicarpa acuminata	Human Edible Plant
BXGF03923	Ageratum mexicanum	Ageratum mexicanum	Others
BXGF03936	Petunia nyctaginiflora	Petunia nyctaginiflora	Medicinal Plant
BXGF03956	Arnica parryi	Arnica parryi	Others
BXGF03983	Kalanchoe spathulata	Kalanchoe spathulata	Medicinal Plant
BXGF04053	Smilax china	Smilax china	Medicinal Plant
BXGF04271	Artemisia annua	Artemisia annua	Medicinal Plant
BXGF04372	Kniphofia foliosa	Kniphofia foliosa	Human Edible Plant
BXGF04604	Viguiera pinnatilobata	Viguiera pinnatilobata	Others
BXGF04897	Alstonia spectabilis	Alstonia spectabilis	Medicinal Plant
BXGF05383	Alpinia galanga	Alpinia galanga	Medicinal Plant
BXGF05436	Rubia tetragona	Rubia tetragona	Others
BXGF05819	Citrus aurantium	Citrus aurantium	Medicinal Plant
BXGF05831	Rosa laevigata	Rosa laevigata	Medicinal Plant
BXGF05858	Ormosia hosiei	Ormosia hosiei	Medicinal Plant
BXGF06250	Licaria chrysophylla	Licaria chrysophylla	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}