Showing entry for DNA topoisomerase 2-beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012677
Protein NameDNA topoisomerase 2-beta
Uniport IdQ02880
GeneTOP2B
Gene Id7155
DomainDNA_gyraseB; DNA_topoisoIV; DTHCT; HATPase_c; Toprim; TOPRIM_C
Pfam PF00204   PF00521   PF08070   PF02518   PF01751   PF16898  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01524 Platinum drug resistance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007409 axonogenesis
Biological Process GO:0006265 DNA topological change
Biological Process GO:0030900 forebrain development
Biological Process GO:0044774 mitotic DNA integrity checkpoint
Biological Process GO:0001764 neuron migration
Biological Process GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
Biological Process GO:0000712 resolution of meiotic recombination intermediates
Biological Process GO:0000819 sister chromatid segregation
molecular function GO:0005524 ATP binding
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
molecular function GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
molecular function GO:0019899 enzyme binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0046872 metal ion binding
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0005080 protein kinase C binding
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:1990904 ribonucleoprotein complex
cellular component GO:0019035 viral integration complex
Reactome
Pathway Id Pathway Name
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-392499 Metabolism of proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0023466 BXGD001657 Leukemia, Monocytic, Chronic Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0085390 BXGD003160 Li-Fraumeni Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0206715 BXGD004261 Neoplasms, Neuroepithelial Neoplasms
C0235950 BXGD004790 Zinc deficiency Nutritional and Metabolic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0282612 BXGD006820 Prostatic Intraepithelial Neoplasias Neoplasms
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0557874 BXGD009444 Global developmental delay
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1859592 BXGD015912 ATRICHIA WITH PAPULAR LESIONS Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C2363741 BXGD017100 HIV-1 infection
C2825306 BXGD017772 Treatment related leukaemia Neoplasms
C2875301 BXGD017837 Dominantly inherited sensory neuropathy
C3149841 BXGD018287 POLYCYSTIC KIDNEY DISEASE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3888194 BXGD019955 MIXED LINEAGE LEUKEMIA
C4054726 BXGD021987 Infant Leukemia
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000332 Fisetin 286.24
BXGC0000363 Galangin 270.24
BXGC0002071 Apigenin 270.24
BXGC0002588 Magnesium 24.31
BXGC0003690 Glucokinin 764.94
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0005844 Cholestanol 388.67
BXGC0006193 Ellagic acid 302.19
BXGC0006306 Myricetin 318.24
BXGC0008167 Chrysin 254.24
BXGC0008840 Kaempferide 300.26
BXGC0012763 (5R,5Ar)-5-(4-Hydroxy-3,5-Dimethoxyphenyl)-5A,8,8A,9-Tetrahydro-5H-[2]Benzofuro[5,6-F][1,3]Benzodioxol-6-One 384.12
BXGC0015787 Shermilamine C 430.15
BXGC0016470 Camptothecin 348.11
BXGC0019342 4'-Demethylpodophyllotoxin 400.12
BXGC0021067 alpha-peltatin 400.12
BXGC0021835 7,8-Dihydroxyflavone 254.06
BXGC0028996 3,5,7-Trihydroxy-3',4',5'-Trimethoxyflavone 360.08
BXGC0029547 Lycobetaine 266.08
BXGC0030138 Colchicine 399.17
BXGC0031622 Podofilox 414.13
BXGC0034783 Doxorubicin 543.17
BXGC0035474 rabdosiin 718.15
BXGC0036821 5,6-Dihydroxy-7-Methoxyflavone 284.07
BXGC0038233 Nalidixic Acid 232.08
BXGC0038316 Cholesterol 386.35
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
BXGC0050657 Dehydrokuanoniamine B 400.14
BXGC0051568 Rabdosiin 718.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein