Showing entry for 7,8-Dihydroxyflavone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0021835
Compound Name7,8-Dihydroxyflavone
Structure
FormulaC15H10O4
InchiKeyCOCYGNDCWFKTMF-UHFFFAOYSA-N
SMILESOc1ccc2c(c1O)oc(cc2=O)c1ccccc1
InchiInChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
IUPAC7,8-dihydroxy-2-phenylchromen-4-one
Molecular Weight254.06
Pubchem Id1880
Chembl IdCHEMBL75267
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50093539
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK - 8 - -
reviewed BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT - 36000 - -
reviewed BXGT007329 DNA gyrase subunit A reviewed gyrA - 350000 - -
reviewed BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta reviewed Kinase IKBKB - 9820 - -
reviewed BXGT013645 BDNF/NT-3 growth factors receptor reviewed Kinase NTRK2 - - 320 -
CHEMBL CHEMBL75267
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta reviewed Kinase IKBKB IC50 '=' 9820 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Inhibition '=' 4 %
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Inhibition '=' 4 %
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 5011 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 39810 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 15848 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 28183 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 28183 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 107 %
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 '=' 80 ug.mL-1
Q92934 BXGT019396 Bcl2-associated agonist of cell death reviewed - BAD Activity - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 56234 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 39810 nM
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial reviewed Enzyme ALDH2 Control '=' 92 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 31622 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 3162 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 15848 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 10000 nM
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial reviewed Enzyme ALDH2 Control '=' 59 %
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 35481 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 7924 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 '=' 17000 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 '=' 17000 nM
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial reviewed Enzyme ALDH2 IC50 - - -
Q63604 BXGT016074 BDNF/NT-3 growth factors receptor reviewed - Ntrk2 Activity - - -
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 10000 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 3981 nM
O14746 BXGT004091 Telomerase reverse transcriptase reviewed Enzyme TERT IC50 '=' 36000 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 31622 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Inhibition '=' 25 %
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Inhibition '=' 25 %
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial reviewed Enzyme ALDH2 Control '=' 92 %
P0AES4 BXGT007329 DNA gyrase subunit A reviewed - gyrA IC50 '=' 89 ug.mL-1
P0AES6 BXGT007331 DNA gyrase subunit B reviewed - gyrB IC50 '=' 89 ug.mL-1
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 12589 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
Q63604 BXGT016074 BDNF/NT-3 growth factors receptor reviewed - Ntrk2 Inhibition - - -
Q02880 BXGT012677 DNA topoisomerase 2-beta reviewed - TOP2B CC50 '=' 95 ug.mL-1
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Inhibition '=' 7 %
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Inhibition '=' 7 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 8912 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 12589 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 19952 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 7943 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 23109 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 2511 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Inhibition '=' 53 %
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Inhibition '=' 53 %
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 25118 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 5623 nM
Q16620 BXGT013645 BDNF/NT-3 growth factors receptor reviewed Kinase NTRK2 Kd '=' 320 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 140 %
P25084 BXGT009013 Transcriptional activator protein LasR reviewed - lasR Inhibition '>' 70 %
P54292 BXGT011041 Regulatory protein RhlR reviewed - rhlR Inhibition '>' 70 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF04964 Chrysanthemum morifolium Chrysanthemum morifolium Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease