Showing entry for Nalorphine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0032351
Compound NameNalorphine
Structure
FormulaC19H21NO3
InchiKeyUIQMVEYFGZJHCZ-SSTWWWIQSA-N
SMILESC=CCN1CC[C@@]23[C@@H]4[C@H]1Cc1c3c(O[C@H]2[C@H](C=C4)O)c(cc1)O
InchiInChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1
IUPAC(4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Molecular Weight311.15
Pubchem Id5284595
Chembl IdCHEMBL415284
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50367061
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT010224 Kappa-type opioid receptor reviewed OPRK1 15 - - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 - 4000 - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 - 93 - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 - 625 - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 - 1800 - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 - 48 - -
reviewed BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 120 - - -
reviewed BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 2 - - -
reviewed BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 0.36 - - -
reviewed BXGT009730 Kappa-type opioid receptor reviewed Oprk1 - 160 - -
reviewed BXGT009730 Kappa-type opioid receptor reviewed Oprk1 - 59 - -
reviewed BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 - 28 - -
reviewed BXGT009731 Mu-type opioid receptor reviewed Oprm1 - - - 1.5
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 - 735 - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 - 5000 - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 - 2850 - -
reviewed BXGT009731 Mu-type opioid receptor reviewed Oprm1 2 - - -
reviewed BXGT009731 Mu-type opioid receptor reviewed Oprm1 6.5 - - -
reviewed BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 0.38 - - -
reviewed BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 0.19 - - -
CHEMBL CHEMBL415284
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Vmax '=' 461 pmol/min/mg protein
P33534 BXGT009730 Kappa-type opioid receptor reviewed - Oprk1 IC50 '=' 59 nM
P32300 BXGT009618 Delta-type opioid receptor reviewed - Oprd1 IC50 '=' 59 nM
P42866 BXGT010343 Mu-type opioid receptor reviewed - Oprm1 IC50 '=' 59 nM
P33534 BXGT009730 Kappa-type opioid receptor reviewed - Oprk1 Concentration '=' 286 nM
P32300 BXGT009618 Delta-type opioid receptor reviewed - Oprd1 Concentration '=' 286 nM
P42866 BXGT010343 Mu-type opioid receptor reviewed - Oprm1 Concentration '=' 286 nM
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 0 pm/min/mg
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki '=' 2 nM
P33535 BXGT009731 Mu-type opioid receptor reviewed - Oprm1 ED50 '=' 2 umol.kg-1
P34975 BXGT009780 Kappa-type opioid receptor reviewed - Oprk1 ED50 '=' 2 umol.kg-1
P33533 BXGT009729 Delta-type opioid receptor reviewed - Oprd1 ED50 '=' 2 umol.kg-1
P33534 BXGT009730 Kappa-type opioid receptor reviewed - Oprk1 Concentration '=' 22 nM
P32300 BXGT009618 Delta-type opioid receptor reviewed - Oprd1 Concentration '=' 22 nM
P42866 BXGT010343 Mu-type opioid receptor reviewed - Oprm1 Concentration '=' 22 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 0 pm/min/mg
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity '=' 1483 pm/min/mg
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Km '=' 2075000 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Vmax '=' 2 pmol/min/mg protein
P33535 BXGT009731 Mu-type opioid receptor reviewed - Oprm1 Ki '=' 6 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 48 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki '=' 120 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki '=' 0 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 625 nM
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Activity '=' 0 pm/min/mg
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 93 nM
P41144 BXGT010224 Kappa-type opioid receptor reviewed - OPRK1 Ki '=' 15 nM
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki '=' 0 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 5000 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 735 nM
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity '=' 1051 pm/min/mg
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 '=' 28 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 '=' 28 nM
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 '=' 28 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 1800 nM
P33534 BXGT009730 Kappa-type opioid receptor reviewed - Oprk1 IC50 '=' 160 nM
P32300 BXGT009618 Delta-type opioid receptor reviewed - Oprd1 IC50 '=' 160 nM
P42866 BXGT010343 Mu-type opioid receptor reviewed - Oprm1 IC50 '=' 160 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 4000 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 2850 nM
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Activity '=' 51 pm/min/mg
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Km '=' 260000 nM
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 75 pm/min/mg
P33535 BXGT009731 Mu-type opioid receptor reviewed - Oprm1 IC50 '=' 2 nM
P34975 BXGT009780 Kappa-type opioid receptor reviewed - Oprk1 IC50 '=' 2 nM
P33533 BXGT009729 Delta-type opioid receptor reviewed - Oprd1 IC50 '=' 2 nM
P33535 BXGT009731 Mu-type opioid receptor reviewed - Oprm1 Ratio IC50 '=' 3 -
P34975 BXGT009780 Kappa-type opioid receptor reviewed - Oprk1 Ratio IC50 '=' 3 -
P33533 BXGT009729 Delta-type opioid receptor reviewed - Oprd1 Ratio IC50 '=' 3 -
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity '=' 134 pm/min/mg
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity '=' 3400 pm/min/mg
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 28183 nM
P33535 BXGT009731 Mu-type opioid receptor reviewed - Oprm1 IC50 '=' 6 nM
P34975 BXGT009780 Kappa-type opioid receptor reviewed - Oprk1 IC50 '=' 6 nM
P33533 BXGT009729 Delta-type opioid receptor reviewed - Oprd1 IC50 '=' 6 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ke '=' 4 nM
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ke '=' 4 nM
P33535 BXGT009731 Mu-type opioid receptor reviewed - Oprm1 EC50 '=' 1 nM
P34975 BXGT009780 Kappa-type opioid receptor reviewed - Oprk1 EC50 '=' 1 nM
P33533 BXGT009729 Delta-type opioid receptor reviewed - Oprd1 EC50 '=' 1 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki '=' 0 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00402 Opium poppy Papaver somniferum Herbs and Spices
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease