Showing entry for UDP-glucuronosyltransferase 1-4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008754
Protein NameUDP-glucuronosyltransferase 1-4
Uniport IdP22310
GeneUGT1A4
Gene Id54657
DomainUDPGT
Pfam PF00201  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00040 Pentose and glucuronate interconversions
1. Metabolism 1.1 Carbohydrate metabolism hsa00053 Ascorbate and aldarate metabolism
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00860 Porphyrin and chlorophyll metabolism
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.1 Cancers: Overview hsa05204 Chemical carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006789 bilirubin conjugation
Biological Process GO:0052695 cellular glucuronidation
Biological Process GO:0052696 flavonoid glucuronidation
Biological Process GO:0042167 heme catabolic process
Biological Process GO:2001030 negative regulation of cellular glucuronidation
Biological Process GO:0045922 negative regulation of fatty acid metabolic process
Biological Process GO:1904224 negative regulation of glucuronosyltransferase activity
Biological Process GO:0052697 xenobiotic glucuronidation
molecular function GO:0019899 enzyme binding
molecular function GO:0015020 glucuronosyltransferase activity
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-156588 Glucuronidation
R-HSA-1643685 Disease
R-HSA-189445 Metabolism of porphyrins
R-HSA-189483 Heme degradation
R-HSA-211859 Biological oxidations
R-HSA-5579016 Defective UGT1A4 causes hyperbilirubinemia
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5668914 Diseases of metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002312 BXGD000107 alpha-Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002875 BXGD000135 Cooley's anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010324 BXGD000663 Crigler Najjar syndrome, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0011226 BXGD000704 Hepatitis D Infection Digestive System Diseases; Infections
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017205 BXGD001105 Gaucher Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017551 BXGD001116 Gilbert Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022610 BXGD001566 Kernicterus Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037889 BXGD002709 Hereditary spherocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0039730 BXGD002826 Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0268138 BXGD005833 Xeroderma Pigmentosum, Complementation Group D Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0268306 BXGD005891 Unconjugated hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0270210 BXGD006068 Lucey-Driscoll syndrome (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0271979 BXGD006283 Thalassemia Intermedia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0311468 BXGD006885 Increased bilirubin level (finding) Pathological Conditions, Signs and Symptoms
C0337438 BXGD007159 Glucose measurement
C0342751 BXGD007542 Generalized glycogen storage disease of infants Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0344395 BXGD007668 Bilirubin measurement
C0376154 BXGD007980 Skin callus Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0489786 BXGD009018 Height
C0495706 BXGD009038 elevated blood glucose level
C0523465 BXGD009209 Serum albumin measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699889 BXGD009870 Malignant Female Reproductive System Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0741494 BXGD010035 Elevated total bilirubin
C0857007 BXGD011131 Hyperbilirubinemia, Neonatal Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0860218 BXGD011222 ABO incompatibility Immune System Diseases; Hemic and Lymphatic Diseases
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C1287365 BXGD012174 Bilirubin level result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1337013 BXGD012876 Differentiated Thyroid Gland Carcinoma
C1445957 BXGD013081 Serum total cholesterol measurement
C1456873 BXGD013129 alpha^+^ Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1562113 BXGD013372 Fleck corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1611743 BXGD013456 Familial (FPAH)
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1859236 BXGD015867 Prolonged neonatal jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1866173 BXGD016380 BILIRUBIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1
C2931132 BXGD017963 Crigler Najjar syndrome, type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2939465 BXGD018182 Deficiency of glucose-6-phosphate dehydrogenase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3841475 BXGD019800 beta^+^ Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4303163 BXGD022553 Autoimmune hepatitis type 2
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722172 BXGD023791 Primary differentiated carcinoma of thyroid gland
C4755308 BXGD024094 Familial cervical artery dissection
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000332 Fisetin 286.24
BXGC0000363 Galangin 270.24
BXGC0000383 (S)-Naringenin 272.25
BXGC0000663 Papain 206.28
BXGC0000681 Umbelliferone 162.14
BXGC0000819 Nopol 166.26
BXGC0001868 Catechin 290.27
BXGC0001899 Daidzein 254.24
BXGC0002052 Aesculetin 178.14
BXGC0002071 Apigenin 270.24
BXGC0002610 Aniline 93.13
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0002725 1,4-Terpinenol 154.25
BXGC0003258 N,N-Dimethylaniline 121.18
BXGC0003485 Naphthalen-1-ol 144.17
BXGC0003516 (-)-alpha-Fenchol 154.25
BXGC0003773 Estriol 288.38
BXGC0003949 Thymunic acid 150.22
BXGC0004378 3-Hydroxyflavone 238.24
BXGC0004705 Diphenylamine 169.22
BXGC0004719 2-Biphenylol 170.21
BXGC0005654 Naringin 580.53
BXGC0005683 Quercetin 302.24
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005867 Serotonin 176.22
BXGC0005870 Codeine 299.36
BXGC0005871 Dopamine 153.18
BXGC0005879 Eugenol 164.2
BXGC0006276 Tigogenin 416.64
BXGC0006291 Scopoletin 192.17
BXGC0006362 Estrone 270.37
BXGC0006366 trans-Ferulic acid 194.18
BXGC0006372 Ergocalciferol 396.65
BXGC0006919 (-)-trans-Carveol 152.23
BXGC0007029 Emodin 270.24
BXGC0007393 2-Bornanol 154.25
BXGC0007525 (-)-Menthol 156.27
BXGC0007526 (+)-Neomenthol 156.27
BXGC0007535 5-Isopropyl-2-methylphenol 150.22
BXGC0007821 Linalool 154.25
BXGC0008167 Chrysin 254.24
BXGC0012228 Vitamin D 384.64
BXGC0012243 Ukonan D 151.16
BXGC0013544 Naphthalen-1-Amine 143.07
BXGC0016891 Nortriptyline 263.17
BXGC0017489 Oleandomycin 687.42
BXGC0017965 4-Hydroxycoumarins 162.03
BXGC0018834 (+)-Menthol 156.15
BXGC0018843 Quinalizarin 272.03
BXGC0020800 Testosterone 288.21
BXGC0022978 Biphenyl-4-Amine 169.09
BXGC0025066 Benzidine 184.1
BXGC0025862 Levothyroxine 776.69
BXGC0026391 Naloxone 327.15
BXGC0027421 Paclitaxel 853.33
BXGC0028314 alpha-terpineol 154.14
BXGC0029355 Pregnenolone 316.24
BXGC0030901 Morphine 285.14
BXGC0032207 Disogenin 414.31
BXGC0032351 Nalorphine 311.15
BXGC0035201 Quinidine 324.18
BXGC0037915 isoborneol 154.14
BXGC0038073 isoborneol 154.14
BXGC0039397 Athraquinones A 240.04
BXGC0039507 Digitoxigenin 374.25
BXGC0041894 Questiomycin B 109.05
BXGC0042460 Betanaphthol 144.06
BXGC0044222 Androstane-3,11,17-triol # 308.24
BXGC0044334 P-Nitrophenol 139.03
BXGC0045812 Trifluoperazine 407.16
BXGC0047169 Hymecromone 176.05
BXGC0047568 Retinol 286.23
BXGC0049170 Oxycodone 315.15
BXGC0049633 4-Aminophenol 109.05
BXGC0052712 Anthraflavicacid 240.04
BXGC0053494 Quinizarin 240.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein