acompound

Showing entry for 1H-Benzimidazol-2-Amine

　　　　　　　　　　　　　　　

General Compound Information
BXGC Id	BXGC0042188
Compound Name	1H-Benzimidazol-2-Amine
Structure
Formula	C7H7N3
InchiKey	JWYUFVNJZUSCSM-UHFFFAOYSA-N
SMILES	N=c1[nH]c2c([nH]1)cccc2
Inchi	InChI=1S/C7H7N3/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H3,8,9,10)
IUPAC	1H-benzimidazol-2-amine
Molecular Weight	133.06
Pubchem Id	13624
Chembl Id	CHEMBL305513

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
O76290	BXGT005181	Pteridine reductase	unreviewed	PTR1	-	288000	-	-	-
P11086	BXGT007652	Phenylethanolamine N-methyltransferase	reviewed	PNMT	Enzyme	-	-	6300	-
P08709	BXGT006818	Coagulation factor VII	reviewed	F7	Enzyme	-	-	-	-
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	reviewed	PIK3CA	Kinase	-	-	-	-
P0AES6	BXGT007331	DNA gyrase subunit B	reviewed	gyrB	-	-	-	-	-
P0A0K8	BXGT006971	DNA gyrase subunit B	reviewed	gyrB	-	-	-	-	-
P36639	BXGT009930	7,8-dihydro-8-oxoguanine triphosphatase	reviewed	NUDT1	Enzyme	-	-	-	-

Binding DB

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT013665	Glutaminyl-peptide cyclotransferase	reviewed	Enzyme	QPCT	1800000	-	-	-
reviewed	BXGT013588	Tryptase alpha/beta-1	reviewed		TPSAB1	110000	-	-	-
reviewed	BXGT008550	Tryptase beta-2	reviewed		TPSB2	110000	-	-	-
reviewed	BXGT005644	Cationic trypsin	reviewed		-	200000	-	-	-
reviewed	BXGT005641	Urokinase-type plasminogen activator	reviewed	Enzyme	PLAU	-	200000	-	-
reviewed	BXGT013683	Membrane primary amine oxidase	reviewed		AOC3	-	4100	-	-
reviewed	BXGT004032	Membrane primary amine oxidase	reviewed		Aoc3	-	1000	-	-

CHEMBL

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	19952	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	19952	nM
Q582G3	BXGT015184	Bifunctional dihydrofolate reductase-thymidylate synthase	unreviewed	-	Tb927.7.5480	Inhibition	-	-	-
P00374	BXGT005520	Dihydrofolate reductase	reviewed	Enzyme	DHFR	Inhibition	-	-	-
O94782	BXGT005332	Ubiquitin carboxyl-terminal hydrolase 1	reviewed	Enzyme	USP1	Potency	-	177	nM
Q581W1	BXGT015180	Pteridine reductase, putative	unreviewed	-	Tb927.8.2210	Ki	'='	288000	nM
P00352	BXGT005510	Retinal dehydrogenase 1	reviewed	Enzyme	ALDH1A1	Potency	'='	19952	nM
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	reviewed	Kinase	PIK3CA	Inhibition	'<'	25	%
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	reviewed	Nuclear receptor	PPARD	Potency	-	11220	nM
P00749	BXGT005641	Urokinase-type plasminogen activator	reviewed	Enzyme	PLAU	IC50	'='	200000	nM
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	reviewed	Kinase	PIK3CA	Inhibition	'<'	25	%
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	reviewed	Kinase	PIK3R1	Inhibition	'<'	25	%
O00167	BXGT003887	Eyes absent homolog 2	reviewed	-	EYA2	Potency	-	19952	nM
O08590	BXGT004032	Membrane primary amine oxidase	reviewed	-	Aoc3	IC50	'='	1000	nM
P19793	BXGT008515	Retinoic acid receptor RXR-alpha	reviewed	Nuclear receptor	RXRA	Potency	-	31622	nM
P10275	BXGT007552	Androgen receptor	reviewed	Nuclear receptor	AR	Potency	-	28183	nM
Q16853	BXGT013683	Membrane primary amine oxidase	reviewed	-	AOC3	IC50	'='	4100	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	6513	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF04982	Ligusticum chuanxiong	Ligusticum chuanxiong	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}