Showing entry for Coagulation factor VII


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006818
Protein NameCoagulation factor VII
Uniport IdP08709
GeneF7
Gene Id2155
DomainEGF; Gla; Trypsin
Pfam PF00008   PF00594   PF00089  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031100 animal organ regeneration
Biological Process GO:0007596 blood coagulation
Biological Process GO:0007598 blood coagulation, extrinsic pathway
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0030194 positive regulation of blood coagulation
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0002690 positive regulation of leukocyte chemotaxis
Biological Process GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway
Biological Process GO:0050927 positive regulation of positive chemotaxis
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0016485 protein processing
Biological Process GO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxine
Biological Process GO:0061476 response to anticoagulant
Biological Process GO:1905217 response to astaxanthin
Biological Process GO:0010037 response to carbon dioxide
Biological Process GO:0070723 response to cholesterol
Biological Process GO:0032355 response to estradiol
Biological Process GO:0043627 response to estrogen
Biological Process GO:0033595 response to genistein
Biological Process GO:0060416 response to growth hormone
Biological Process GO:0001666 response to hypoxia
Biological Process GO:1904400 response to Thyroid stimulating hormone
Biological Process GO:1905225 response to thyrotropin-releasing hormone
Biological Process GO:0097068 response to thyroxine
Biological Process GO:0032571 response to vitamin K
molecular function GO:0005509 calcium ion binding
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0008236 serine-type peptidase activity
molecular function GO:0005102 signaling receptor binding
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005796 Golgi lumen
cellular component GO:0005886 plasma membrane
cellular component GO:1905286 serine-type peptidase complex
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade)
R-HSA-159740 Gamma-carboxylation of protein precursors
R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-392499 Metabolism of proteins
R-HSA-400253 Circadian Clock
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010324 BXGD000663 Crigler Najjar syndrome, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012739 BXGD000786 Disseminated Intravascular Coagulation Hemic and Lymphatic Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0015503 BXGD000998 Factor VII Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0017565 BXGD001118 Gingival Hemorrhage Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0018924 BXGD001249 Hemarthrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019080 BXGD001279 Hemorrhage Pathological Conditions, Signs and Symptoms
C0019087 BXGD001280 Hemorrhagic Disorders Hemic and Lymphatic Diseases
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0020435 BXGD001380 Hyperbilirubinemia, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020476 BXGD001398 Hyperlipoproteinemias Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020640 BXGD001458 Inherited Factor II deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0025323 BXGD001864 Menorrhagia Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027660 BXGD002013 Neoplasms, Glandular and Epithelial Neoplasms
C0029927 BXGD002182 Ovarian Cysts Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032787 BXGD002371 Postoperative Complications Pathological Conditions, Signs and Symptoms
C0032797 BXGD002373 Postpartum Hemorrhage Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040038 BXGD002837 Thromboembolism Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042487 BXGD002986 Venous Thrombosis Cardiovascular Diseases
C0042880 BXGD003011 Vitamin K Deficiency Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151699 BXGD003461 Intracranial Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0151872 BXGD003493 Prothrombin time increased Hemic and Lymphatic Diseases
C0151942 BXGD003507 Arterial thrombosis Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151945 BXGD003508 Thrombosis of cerebral veins Nervous System Diseases; Cardiovascular Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0240412 BXGD005034 Muscle hematoma Pathological Conditions, Signs and Symptoms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0266785 BXGD005712 Abnormal umbilical cord Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0268542 BXGD005977 Ornithine carbamoyltransferase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0392885 BXGD008071 High density lipoprotein measurement
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0472802 BXGD008924 Hereditary factor VIII deficiency disease with inhibitor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0553692 BXGD009408 Brain hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684275 BXGD009792 Hemophilia, NOS Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0749098 BXGD010209 Hematoma, Subdural, Acute Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases; Wounds and Injuries
C0751797 BXGD010596 Intracranial Hematoma, Traumatic Nervous System Diseases; Cardiovascular Diseases; Wounds and Injuries
C0751893 BXGD010634 Posterior Fossa Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0795953 BXGD010770 MASA SYNDROME (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1167912 BXGD011778 Coagulation factor measurement
C1269955 BXGD012005 Tumor Cell Invasion
C1445957 BXGD013081 Serum total cholesterol measurement
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1611743 BXGD013456 Familial (FPAH)
C1832662 BXGD013867 MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1861403 BXGD016045 Variable expressivity
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2239219 BXGD016966 von Willebrand's factor (lab test)
C2608079 BXGD017154 WARFARIN SENSITIVITY (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2825856 BXGD017776 Factor VII measurement
C2937358 BXGD018159 Cerebral Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C4021646 BXGD020717 Prolonged bleeding after surgery
C4024722 BXGD021385 Reduced factor VII activity
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002825 Hexadecenoic acid 254.41
BXGC0003627 alpha-Linoleic acid 280.45
BXGC0003628 Dihomolinolenic acid 306.48
BXGC0003685 Myristolic acid 226.36
BXGC0003705 Chloride 35.45
BXGC0004264 1-Propanol 60.1
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0005625 alpha-D-Glucopyranose 180.16
BXGC0005659 Arachidonic acid 304.47
BXGC0005794 Benzylamine 107.15
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0006125 Nicotinamide 122.12
BXGC0009712 2-(10-Heptadecenyl)-6-hydroxybenzoic acid 374.56
BXGC0014782 Icosapent 302.22
BXGC0018736 Benzamide 121.05
BXGC0019792 Dihomo-Gamma-Linolenic Acid 306.26
BXGC0023292 Gingkolic Acid 346.25
BXGC0029732 xylose 150.05
BXGC0034894 Oleic Acid 282.26
BXGC0035544 1,5-anhydroglucitol 164.07
BXGC0042188 1H-Benzimidazol-2-Amine 133.06
BXGC0047405 Gamolenic Acid 278.22
BXGC0048305 (11Z,14Z)-Icosa-11,14-Dienoic Acid 308.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein