Showing entry for Thymidine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0049801
Compound NameThymidine
Structure
FormulaC10H14N2O5
InchiKeyIQFYYKKMVGJFEH-XLPZGREQSA-N
SMILESOC[C@H]1O[C@H](C[C@@H]1O)n1cc(C)c(nc1=O)O
InchiInChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1
IUPAC1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Molecular Weight242.09
Pubchem Id5789
Chembl IdCHEMBL52609
Targets of Information Source
DrugBank DB04485
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P24425 BXGT008968 Thymidine kinase reviewed - TK experimental; investigational -
O00142 BXGT003883 Thymidine kinase 2, mitochondrial reviewed Kinase TK2 experimental; investigational -
Q9HU22 BXGT020602 Glucose-1-phosphate thymidylyltransferase unreviewed - rmlA experimental; investigational -
P0A927 BXGT007167 Nucleoside-specific channel-forming protein Tsx reviewed - tsx experimental; investigational -
P9WKE1 BXGT012362 Thymidylate kinase reviewed - tmk experimental; investigational -
P03176 BXGT006030 Thymidine kinase reviewed - TK experimental; investigational -
P12758 BXGT007845 Uridine phosphorylase reviewed - udp experimental; investigational -
PDB THM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P03176 BXGT006030 Thymidine kinase reviewed TK - - - - -
Q9HU22 BXGT020602 Glucose-1-phosphate thymidylyltransferase unreviewed rmlA - - - - -
P37744 BXGT010007 Glucose-1-phosphate thymidylyltransferase 1 reviewed rfbA - - - - -
Q9XZT6 BXGT022202 Deoxynucleoside kinase reviewed dnk - - - - -
P24425 BXGT008968 Thymidine kinase reviewed TK - - - - -
P12758 BXGT007845 Uridine phosphorylase reviewed udp - - - - -
P0A927 BXGT007167 Nucleoside-specific channel-forming protein Tsx reviewed tsx - - - - -
P9WKE1 BXGT012362 Thymidylate kinase reviewed tmk - 27000 - - -
Q9PPP5 BXGT021348 Thymidine kinase reviewed tdk - - - - -
Q81JX0 BXGT017338 Thymidine kinase reviewed tdk - - - - -
Q9WYN2 BXGT021992 Thymidine kinase reviewed tdk - - - - -
Q5SIP1 BXGT015722 5'-nucleotidase unreviewed TTHA1328 - - - - -
P00489 BXGT005553 Glycogen phosphorylase, muscle form reviewed PYGM - - - - -
Q5HE64 BXGT015399 Pyrimidine-nucleoside phosphorylase reviewed pdp - - - - -
Q9KQI2 BXGT020980 Thymidylate kinase reviewed tmk - - - - -
Q8K4Z3 BXGT018403 NAD(P)H-hydrate epimerase reviewed Naxe - - - - -
Q9HZN8 BXGT020681 Thymidylate kinase reviewed tmk - - - - -
Q9K4U1 BXGT020874 Uridine phosphorylase unreviewed udp - - - - -
Q5SFD1 BXGT015660 dTDP-4-dehydro-6-deoxyglucose 3-epimerase reviewed chmJ - - - - -
Q9AGY4 BXGT020064 Glucose-1-phosphate thymidylyltransferase unreviewed rmlA - - - - -
Q2KDX6 BXGT014114 Probable sugar kinase protein unreviewed RHE_CH00135 - - - - -
P0A1F6 BXGT006985 Uridine phosphorylase reviewed udp - - - - -
Q6PL18 BXGT016479 ATPase family AAA domain-containing protein 2 reviewed ATAD2 Epigenetic regulator - - - -
G4VGI0 BXGT003512 Putative uridine phosphorylase reviewed UPPA - - - - -
Q4QC75 BXGT014869 Thymidine kinase unreviewed LMJF_21_1210 - - - - -
Q7CP66 BXGT016935 Thymidine phosphorylase reviewed deoA - - - - -
Q6TFC5 BXGT016541 QdtA unreviewed qdtA - - - - -
K4P132 BXGT003781 N-methyltransferase unreviewed - - - - -
Q38CF2 BXGT014364 Thymidine kinase, putative unreviewed Tb10.70.7270 - - - - -
A4JIV2 BXGT001236 Glucose-1-phosphate thymidylyltransferase unreviewed Bcep1808_3215 - - - - -
A0A410UCT3 BXGT024581 Uridine phosphorylase unreviewed up - - - - -
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL52609
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P9WKE1 BXGT012362 Thymidylate kinase reviewed - tmk Ki '=' 27000 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 IC50 '>' 500000 nM
Q0H0G9 BXGT013084 Thymidine kinase unreviewed - tdk Kcat/Km '=' 1 10'5/M/s
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Vmax '=' 1 mM/min
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 IC50 '=' 16 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 IC50 '=' 26 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Km '=' 49000 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Activity - - -
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Rate of phosphorylation '=' 1 -
P68563 BXGT011606 Thymidine kinase reviewed - TK Vmax '=' 302 microM/min/mg
P68563 BXGT011606 Thymidine kinase reviewed - TK Ratio '=' 15 -
A3RLP8 BXGT001190 Thymidine kinase unreviewed - UL23 IC50 '=' 4100 nM
A3RLP8 BXGT001190 Thymidine kinase unreviewed - UL23 Ratio '=' 0 -
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Ratio '=' 439 /min.mg
A3RLP8 BXGT001190 Thymidine kinase unreviewed - UL23 Km '=' 650 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Inhibition - - -
P19971 BXGT008537 Thymidine phosphorylase reviewed Enzyme TYMP Km '=' 187000 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Relative Vmax '=' 100 -
P06479 BXGT006443 Thymidine kinase reviewed - TK IC50 '=' 1000 nM
Q0H0G9 BXGT013084 Thymidine kinase unreviewed - tdk Vmax '=' 1 U/mg
Q0H0G9 BXGT013084 Thymidine kinase unreviewed - tdk Kcat '=' 0 /s
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Activity '=' 86 %
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Km '=' 660 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 IC50 '=' 1800 nM
P06479 BXGT006443 Thymidine kinase reviewed - TK Km '=' 810 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Kinase activity '=' 585 pM min-1*ml-1
A3RLP8 BXGT001190 Thymidine kinase unreviewed - UL23 Km '=' 700 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 8912 nM
P06479 BXGT006443 Thymidine kinase reviewed - TK Relative velocity '=' 100 %
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Km '=' 240000 nM
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Activity '=' 0 %
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Vmax '=' 5 mM/min
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Phosphorolysis '=' 72 %
Q9PPP5 BXGT021348 Thymidine kinase reviewed - tdk Ratio '=' 637 /min.mg
Q9PPP5 BXGT021348 Thymidine kinase reviewed - tdk Vmax '=' 1210 nmol/mg.min
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Kinase activity '=' 174 pM min-1*ml-1
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Km '=' 2500000 nM
P27158 BXGT009160 Thymidine kinase, cytosolic reviewed - Tk1 Phosphorylation rate '=' 100 uM
Q9QNF7 BXGT021370 Thymidine kinase reviewed - TK Vmax '=' 17 nmol/hr/microg
A3RLP8 BXGT001190 Thymidine kinase unreviewed - UL23 Vmax '=' 0 nmol/hr/microg
A3RLP8 BXGT001190 Thymidine kinase unreviewed - UL23 Activity '=' 100 %
P07607 BXGT006648 Thymidylate synthase reviewed - Tyms ID50 '=' 75 uM
A3RLP8 BXGT001190 Thymidine kinase unreviewed - UL23 Activity '=' 130 %
P23919 BXGT008926 Thymidylate kinase reviewed Kinase DTYMK Ki '=' 180000 nM
Q9QNF7 BXGT021370 Thymidine kinase reviewed - TK Km '=' 1000 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Km '=' 290 nM
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Kcat '=' 1770 /s
Q0H0G9 BXGT013084 Thymidine kinase unreviewed - tdk Km '=' 2800 nM
Q6PL18 BXGT016479 ATPase family AAA domain-containing protein 2 reviewed Epigenetic regulator ATAD2 Kd '=' 10000000 nM
A3RLP8 BXGT001190 Thymidine kinase unreviewed - UL23 Ratio '=' 0 -
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Vmax '=' 790 nmol/mg.min
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Km '=' 2800 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 ID50 '=' 2 uM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Ki '=' 2000 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Km '=' 1800 nM
Q9QNF7 BXGT021370 Thymidine kinase reviewed - TK Relative velocity '=' 100 %
Q9PPP5 BXGT021348 Thymidine kinase reviewed - tdk Km '=' 1900 nM
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Ratio '=' 7400000 1/Ms
P27158 BXGT009160 Thymidine kinase, cytosolic reviewed - Tk1 Km '=' 8000 nM
Q0H0G9 BXGT013084 Thymidine kinase unreviewed - tdk Ki '=' 257000 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Relative velocity '=' 100 %
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Relative velocity '=' 6 %
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Km '=' 4000 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Ki '=' 200 nM
P27158 BXGT009160 Thymidine kinase, cytosolic reviewed - Tk1 Km '=' 1600 nM
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Km '=' 1000 nM
P9WKE1 BXGT012362 Thymidylate kinase reviewed - tmk Ki '=' 715000 nM
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA k cat '=' 1770 s-1
Q9XZT6 BXGT022202 Deoxynucleoside kinase reviewed - dnk Activity '=' 60000 microM/min/mg
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Km '=' 3000 nM
P04184 BXGT006167 Thymidine kinase, cytosolic reviewed - Tk1 Relative phosphorylation '=' 1 -
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 Relative Vmax '=' 1 -
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Activity - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 18105 nM
P68563 BXGT011606 Thymidine kinase reviewed - TK Km '=' 21000 nM
P07650 BXGT006654 Thymidine phosphorylase reviewed - deoA Activity '=' 82 %
A3RLP8 BXGT001190 Thymidine kinase unreviewed - UL23 Vmax '=' 0 nmol/hr/microg
P04183 BXGT006166 Thymidine kinase, cytosolic reviewed Kinase TK1 k cat '=' 0 s-1
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00013 Dill Anethum graveolens Herbs and Spices
BXGF00019 Tarragon Artemisia dracunculus Herbs and Spices
BXGF00212 Chinese chives Allium tuberosum Herbs and Spices
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00522 Narrowleaf cattail Typha angustifolia Vegetables
BXGF01056 Geigeria schinzii Geigeria schinzii Others
BXGF01093 Fritillaria pallidiflora Fritillaria pallidiflora Medicinal Plant
BXGF01287 Papaver radicatum Papaver radicatum Others
BXGF01347 Fritillaria delavayi Fritillaria delavayi Medicinal Plant
BXGF01413 Fritillaria verticillata Fritillaria verticillata Medicinal Plant
BXGF01420 Pinus glauca Pinus glauca Others
BXGF01479 Fritillaria cirrhosa Fritillaria cirrhosa Medicinal Plant
BXGF01496 Ophryosporus charua Ophryosporus charua Others
BXGF01514 Blainvillea latifolia Blainvillea latifolia Others
BXGF01540 Rhodomyrtus tomentosa Rhodomyrtus tomentosa Medicinal Plant
BXGF01636 Prosopis kuntzei Prosopis kuntzei Medicinal Plant
BXGF01677 Leontice kiangnanensis Leontice kiangnanensis Others
BXGF01705 Cheilanthes marantae Cheilanthes marantae Others
BXGF01776 Fritillaria prezewalskii Fritillaria prezewalskii Others
BXGF01808 Helichrysum angustifolium Helichrysum angustifolium Others
BXGF01868 Vitex negundo Vitex negundo Medicinal Plant
BXGF01913 Fritillaria unibracteata Fritillaria unibracteata Medicinal Plant
BXGF02631 Solanum torvum Solanum torvum Medicinal Plant
BXGF02725 Fritillaria walujewii Fritillaria walujewii Medicinal Plant
BXGF02815 Pinellia ternata Pinellia ternata Medicinal Plant
BXGF02967 Palicourea alpina Palicourea alpina Others
BXGF02982 Lupinus formosus Lupinus formosus Others
BXGF02995 Wunderlichia mirabilis Wunderlichia mirabilis Others
BXGF03010 Posoqueria latifolia Posoqueria latifolia Human Edible Plant
BXGF03026 Dicliptera riparia Dicliptera riparia Medicinal Plant
BXGF03036 Oxandra xylopioides Oxandra xylopioides Others
BXGF03068 Stenocereus thurberi Stenocereus thurberi Human Edible Plant
BXGF03091 Ilex kaushue Ilex kaushue Human Edible Plant
BXGF03116 Dalbergia frutescens Dalbergia frutescens Others
BXGF03128 Colchicum macedonicum Colchicum macedonicum Others
BXGF03137 Euphorbia caducifolia Euphorbia caducifolia Medicinal Plant
BXGF03145 Boronia muelleri Boronia muelleri Others
BXGF03169 Coprosma acerosa Coprosma acerosa Medicinal Plant
BXGF03183 Astilbe koreana Astilbe koreana Others
BXGF03211 Scrophularia smithii Scrophularia smithii Others
BXGF03302 Hypericum papuanum Hypericum papuanum Medicinal Plant
BXGF03329 Zilla spinosa Zilla spinosa Medicinal Plant
BXGF03380 Kaunia arbuscularis Kaunia arbuscularis Others
BXGF03397 Trifolium pratense Trifolium pratense Medicinal Plant
BXGF03425 Sambucus ebulus Sambucus ebulus Medicinal Plant
BXGF03439 Fritillaria przewalskii Fritillaria przewalskii Medicinal Plant
BXGF03441 Inula thapsoides Inula thapsoides Others
BXGF03453 Tylophora flava Tylophora flava Others
BXGF03474 Limeum pterocarpum Limeum pterocarpum Others
BXGF03489 Trifolium alexandrium Trifolium alexandrium Medicinal Plant
BXGF03498 Coptis deltoidea Coptis deltoidea Medicinal Plant
BXGF03517 Cassia carnaval Cassia carnaval Others
BXGF03537 Salix sieboldiana Salix sieboldiana Others
BXGF03811 Euryale ferox Euryale ferox Medicinal Plant
BXGF03868 Dillenia papuana Dillenia papuana Others
BXGF03940 Pachycereus pringlei Pachycereus pringlei Human Edible Plant
BXGF04103 Fritillaria taipaiensis Fritillaria taipaiensis Others
BXGF04600 Typha orientalis Typha orientalis Medicinal Plant
BXGF04855 Cranfillia vulcanica Cranfillia vulcanica Others
BXGF05113 Bersama swinnyi Bersama swinnyi Others
BXGF05281 Fritillaria thunbergii Fritillaria thunbergii Medicinal Plant
BXGF05330 Arum ternatum thunb Arum ternatum thunb Others
BXGF05336 Tanacetum santolinoides Tanacetum santolinoides Human Edible Plant
BXGF05338 Persicaria thunbergii Persicaria thunbergii Medicinal Plant
BXGF05505 Fritillaria ussuriensis Fritillaria ussuriensis Medicinal Plant
BXGF05571 Ziziphus jujuba Ziziphus jujuba Medicinal Plant
BXGF05573 Goniothalamus undulatus Goniothalamus undulatus Others
BXGF05690 Pteris spinulosa Pteris spinulosa Others
BXGF05738 Salvia xalapensis Salvia xalapensis Others
BXGF05863 Allium azureum ledeb Allium azureum ledeb Others
BXGF05915 Fritillaria hupehensis Fritillaria hupehensis Medicinal Plant
BXGF06053 Ficus elastica Ficus elastica Medicinal Plant
BXGF06066 Nemuaron humboldtii Nemuaron humboldtii Others
BXGF06099 Lophocereus marginatus Lophocereus marginatus Medicinal Plant
BXGF06117 Helichrysum sutherlandii Helichrysum sutherlandii Medicinal Plant
BXGF06134 Aralidium pinnatifidum Aralidium pinnatifidum Others
BXGF06206 Hydrangea macrophylla Hydrangea macrophylla Medicinal Plant
BXGF06265 Euphorbia resinifera Euphorbia resinifera Medicinal Plant
BXGF06320 Eurycoma longifolia Eurycoma longifolia Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease